False-Positive Meconium Test Results for Fatty Acid Ethyl Esters Secondary to Delayed Sample Collection

Alcoholism: Clinical and Experimental Research

Volumn 36, Issue 9, 2012, Pages 1497-1506

  Zelner, Irene ^a,b   Hutson, Janine R ^a,c   Kapur, Bhushan M ^a,d   Feig, Denice S ^e   Koren, Gideon ^a,b,c,f  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e MOUNT SINAI HOSPITAL   (Canada)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Contamination; False positive; Fatty acid ethyl esters; Meconium; Prenatal ethanol exposure

Indexed keywords

FATTY ACID ESTER;

ARTICLE; CLINICAL ARTICLE; DIETARY FIBER; EXCRETION; FALSE POSITIVE RESULT; FECES ANALYSIS; FEMALE; HUMAN; IN UTERO STEM CELL TRANSPLANTATION; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; MECONIUM; MICROORGANISM; NEWBORN; NEWBORN PERIOD; PRIORITY JOURNAL; PUERPERIUM; SOLID;

ADULT; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ESTERS; ETHANOL; FALSE POSITIVE REACTIONS; FATTY ACIDS; FECES; FEMALE; FETAL ALCOHOL SYNDROME; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; HUMANS; INFANT, NEWBORN; LIPASE; MECONIUM; PREGNANCY; PROSPECTIVE STUDIES; SOLID PHASE MICROEXTRACTION;

EID: 84865982599     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01763.x     Document Type: Article

References (39)

1. Abu-Shanab A, Quigley EM (2010) The role of the gut microbiota in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 7:691-701.
2. Appenzeller BM, Schuman M, Wennig R (2008) Was a child poisoned by ethanol? Discrimination between ante-mortem consumption and post-mortem formation. Int J Legal Med 122:429-434.
3. Best CA, Laposata M (2003) Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci 8:e202-e217.
4. Bettelheim KA, Breadon A, Faiers MC, O'Farrell SM, Shooter RA (1974) The origin of O serotypes of Escherichia coli in babies after normal delivery. J Hyg (Lond) 72:67-70.
5. Beysen C, Belcher AK, Karpe F, Fielding BA, Herrera E, Frayn KN (2003) Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans. Am J Physiol Endocrinol Metab 284:E18-E24.
6. Boumba VA, Ziavrou KS, Vougiouklakis T (2008) Biochemical pathways generating post-mortem volatile compounds co-detected during forensic ethanol analyses. Forensic Sci Int 174:133-151.
7. Brook I, Barrett CT, Brinkman CR III, Martin WJ, Finegold SM (1979) Aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. Pediatrics 63:451-455.
8. Chan D, Bar-Oz B, Pellerin B, Paciorek C, Klein J, Kapur B, Farine D, Koren G (2003) Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit 25:271-278.
9. Collison IB (2005) Elevated postmortem ethanol concentrations in an insulin-dependent diabetic. J Anal Toxicol 29:762-764.
10. Corry JE (1978) A review. Possible sources of ethanol ante- and post-mortem: its relationship to the biochemistry and microbiology of decomposition. J Appl Bacteriol 44:1-56.
11. Dahshan A, Donovan K (2001) Auto-brewery syndrome in a child with short gut syndrome: case report and review of the literature. J Pediatr Gastroenterol Nutr 33:214-215.
12. Edwards CA, Parrett AM (2002) Intestinal flora during the first months of life: new perspectives. Br J Nutr 88(Suppl 1):S11-S18.
13. Germain M, Thibault L, Jacques A, Tremblay J, Bourgeois R (2010) Heart valve allograft decontamination with antibiotics: impact of the temperature of incubation on efficacy. Cell Tissue Bank 11:197-204.
14. Goh YI, Chudley AE, Clarren SK, Koren G, Orrbine E, Rosales T, Rosenbaum C (2008) Development of Canadian screening tools for fetal alcohol spectrum disorder. Can J Clin Pharmacol 15:e344-e366.
15. Griffin A, Beattie RM (2001) Normal bowel habit during the first 6 weeks in healthy, term infants. Ambulatory Child Health 7:23-26.
16. Hall IC, O'Toole E (1934) Bacterial flora of first specimens of meconium passed by fifty new-born infants. Am J Dis Child 47:1279-1285.
17. Helander A, Hagelberg CA, Beck O, Petrini B (2009) Unreliable alcohol testing in a shipping safety programme. Forensic Sci Int 189:e45-e47.
18. Hutson JR, Rao C, Fulga N, Aleksa K, Koren G (2011) An improved method for rapidly quantifying fatty acid ethyl esters in meconium suitable for prenatal alcohol screening. Alcohol 45:193-199.
19. Jansson-Nettelbladt E, Meurling S, Petrini B, Sjolin J (2006) Endogenous ethanol fermentation in a child with short bowel syndrome. Acta Paediatr 95:502-504.
20. Koren G, Hutson J, Gareri J (2008) Novel methods for the detection of drug and alcohol exposure during pregnancy: implications for maternal and child health. Clin Pharmacol Ther 83:631-634.
21. Krebs HA, Perkins JR (1970) The physiological role of liver alcohol dehydrogenase. Biochem J 118:635-644.
22. Kuhlman JJ Jr, Levine B, Smith ML, Hordinsky JR (1991) Toxicological findings in Federal Aviation Administration general aviation accidents. J Forensic Sci 36:1121-1128.
23. Kumar SL, Dhanireddy R (1995) Time of first stool in premature infants: effect of gestational age and illness severity. J Pediatr 127:971-974.
24. Laposata M (1998) Fatty acid ethyl esters: ethanol metabolites which mediate ethanol-induced organ damage and serve as markers of ethanol intake. Prog Lipid Res 37:307-316.
25. Lewis RJ, Johnson RD, Angier MK, Vu NT (2004) Ethanol formation in unadulterated postmortem tissues. Forensic Sci Int 146:17-24.
26. Lifschitz CH, Wolin MJ, Reeds PJ (1990) Characterization of carbohydrate fermentation in feces of formula-fed and breast-fed infants. Pediatr Res 27:165-169.
27. Lindquist S, Hernell O (2010) Lipid digestion and absorption in early life: an update. Curr Opin Clin Nutr Metab Care 13:314-320.
28. MacGregor RR III, Tunnessen WW Jr (1973) The incidence of pathogenic organisms in the normal flora of the neonate's external ear and nasopharynx. Clin Pediatr (Phila) 12:697-700.
29. Mackie RI, Sghir A, Gaskins HR (1999) Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 69:1035S-1045S.
30. Moore C, Jones J, Lewis D, Buchi K (2003) Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 49:133-136.
31. Moore C, Negrusz A, Lewis D (1998) Determination of drugs of abuse in meconium. J Chromatogr B Biomed Sci Appl 713:137-146.
32. Nair S, Cope K, Risby TH, Diehl AM (2001) Obesity and female gender increase breath ethanol concentration: potential implications for the pathogenesis of nonalcoholic steatohepatitis. Am J Gastroenterol 96:1200-1204.
33. O'Neal CL, Poklis A (1996) Postmortem production of ethanol and factors that influence interpretation: a critical review. Am J Forensic Med Pathol 17:8-20.
34. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO (2007) Development of the human infant intestinal microbiota. PLoS Biol 5:e177.
35. Righetti C, Peroni DG, Pietrobelli A, Zancanaro C (2003) Proton nuclear magnetic resonance analysis of meconium composition in newborns. J Pediatr Gastroenterol Nutr 36:498-501.
36. Sarkola T, Eriksson CJ (2001) Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans. Alcohol Clin Exp Res 25:513-516.
37. Stansbridge EM, Walker V, Hall MA, Smith SL, Millar MR, Bacon C, Chen S (1993) Effects of feeding premature infants with Lactobacillus GG on gut fermentation. Arch Dis Child 69:488-492.
38. Verma A, Dhanireddy R (1993) Time of first stool in extremely low birth weight (< or = 1000 grams) infants. J Pediatr 122:626-629.
39. Wolin MJ, Yerry S, Miller TL, Zhang Y, Bank S (1998) Changes in production of ethanol, acids and H2 from glucose by the fecal flora of a 16- to 158-d-old breast-fed infant. J Nutr 128:85-90.