Heat-inducible transgene expression system incorporating a positive feedback loop of transcriptional amplification for hyperthermia-induced gene therapy

Journal of Bioscience and Bioengineering

Volumn 114, Issue 4, 2012, Pages 460-465

  Yamaguchi, Masaki ^a   Ito, Akira ^a   Okamoto, Noriaki ^a   Kawabe, Yoshinori ^a   Kamihira, Masamichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Gene therapy; Heat shock protein promoter; Hyperthermia; Tetracycline responsive transactivator; Transcriptional amplification

Indexed keywords

AFTER-HEAT TREATMENT; CANCER CELLS; CANCER GENE THERAPY; CYTOTOXIC EFFECTS; EXPRESSION SYSTEM; HEAT SHOCK PROTEIN; HIGH LEVEL EXPRESSION; HYPERTHERMIA; POSITIVE FEEDBACK LOOP; REPORTER GENE; TARGET GENE EXPRESSION; TARGET GENES; THERAPEUTIC EFFECTS; THERAPEUTIC GENES; TRANSACTIVATION; TRANSACTIVATORS; TRANSFECTED CELLS; TRANSGENE EXPRESSION;

CYTOTOXICITY; DISEASES; GENE THERAPY; HEAT TREATMENT; TISSUE;

GENE EXPRESSION;

HEAT SHOCK PROTEIN 70;

ARTICLE; CANCER CELL; CANCER GENE THERAPY; CONTROLLED STUDY; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEAT TREATMENT; HUMAN; HUMAN CELL; PLASMID; POSITIVE FEEDBACK; REPORTER GENE; TRANSACTIVATION; TRANSGENE;

GENE EXPRESSION; GENES, REPORTER; GENETIC THERAPY; GENETIC VECTORS; HEAT-SHOCK PROTEINS; HELA CELLS; HOT TEMPERATURE; HUMANS; NEOPLASMS; PLASMIDS; PROMOTER REGIONS, GENETIC; TRANS-ACTIVATORS; TRANSFECTION; TRANSGENES;

EID: 84865966562     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.05.006     Document Type: Article

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