Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study

Journal of Trauma and Acute Care Surgery

Volumn 73, Issue 3, 2012, Pages 625-628

  Kwiatt, Michael E ^a   Patel, Mitul S ^a   Ross, Steven E ^a   Lachant, Mary T ^a   MacNew, Heather G ^c   Ochsner, M Gage ^c   Norwood, Scott H ^d   Speier, Ladonna ^d   Kozar, Rosemary ^e   Gerber, Jonathan A ^e   Rowell, Susan ^f   Krishnakumar, Sheetal ^f   Livingston, David H ^b   Manis, George ^b   Haan, James M ^g  

^a Department of Anesthesiology   (United States)

^b University of Medicine and Dentistry of New Jersey   (United States)

^c MEMORIAL HEALTH UNIVERSITY MEDICAL CENTER   (United States)

^d EAST TEXAS MEDICAL CENTER   (United States)

^e UNIVERSITY OF TEXAS   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g Christi Regional Medical Center   (United States)

Author keywords

low molecular weight heparin; Traumatic brain injury; venous thromboembolism prophylaxis

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ANTICOAGULATION; ARTICLE; BLUNT TRAUMA; BRAIN HEMORRHAGE; CHEMOPROPHYLAXIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE COURSE; DRUG SAFETY; FEMALE; HUMAN; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; NEUROSURGERY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TRAUMATIC BRAIN INJURY; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

ADULT; AGED; ANTICOAGULANTS; BRAIN INJURIES; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; HEMORRHAGE; HEPARIN, LOW-MOLECULAR-WEIGHT; HOSPITAL MORTALITY; HUMANS; INCIDENCE; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PRIMARY PREVENTION; REFERENCE VALUES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SAFETY MANAGEMENT; SOCIETIES, MEDICAL; SURVIVAL ANALYSIS; TRAUMA CENTERS; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; WOUNDS, NONPENETRATING;

EID: 84865958861     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318265cab9     Document Type: Article

References (19)

1. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;42:456-462.
2. Knudson MM, Ikossi DG, Khaw L, et al. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240:490-498.
3. Adams RC, Hamrick M, Berenguer C, et al. Four years of aggressive prophylaxis in screening protocol for venous thromboembolism in a large trauma population. J Trauma. 2008;65:300-308.
4. Cothren CC, Smith WR, Moore MM, et al. Utility of once-daily dose of low-molecular weight heparin to prevent venous thromboembolism in multisystem trauma patients. World J Surg. 2007;31:98-104.
5. Huseynova K, Xiong W, Ray JG, et al. Venous thromboembolism as a marker of quality of care in trauma. J Am Coll Surg. 2009;208:547-552.
6. Geerts WH, Jay RM, Code KI, et al. A comparison of low-dose heparin with lowYmolecular weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med. 1996;335:701-707.
7. Knudson MM, Morabito D, Paiement GD, et al. Use of low molecular weight heparin in preventing thromboembolism in trauma patients. J Trauma. 1996;41:446-459.
8. Ginzberg E, Cohn SM, Lopez J, et al. Randomized clinical trial of intermittent pneumatic compression and low molecular weight heparin in trauma. Br J Surg. 2003;90:1338-1344.
9. Kurtoglu M, Yanar H, Bilsel Y, et al. Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low molecular weight heparin. World J Surg. 2004;28:807-811.
10. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133: 381-453.
11. Rogers FB, Cipolle MD, Velmahos G, et al. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group. J Trauma. 2002;53:142-164.
12. Norwood SH, McAuley CE, Berne JD, et al. A potentially expanded role for enoxaparin in preventing venous thromboembolism in high risk blunt trauma patients. J Am Coll Surg. 2001;192:161-167.
13. Norwood SH, McAuley CE, Berne JD, et al. Prospective evaluation of the safety of enoxaparin prophylaxis for venous thromboembolism in patients with intracranial hemorrhagic injuries. Arch Surg. 2002;137:696-702.
14. Norwood SH, Berne JD, Rowe SA, et al. Early venous thromboembolism prophylaxis with enoxaparin in patients with blunt traumatic brain injury. J Trauma. 2008;65:1021-1027.
15. Koehler DM, Shipman J, Davidson MA, et al. Is early venous thromboembolism prophylaxis safe in trauma patients with intracranial hemorrhage. J Trauma. 2011;70: 324-329.
16. Levy SA, Salottolo K, Bar-Or R, et al. Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injury. J Trauma. 2010;68:886-894.
17. Patel NY, Hoyt DB, Nakaji O, et al. Traumatic brain injury: patterns of failure of non-operative management. J Trauma. 2000; 49:132-138.
18. Smith JS, Chang EF, Rosenthal G, et al. The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage. J Trauma. 2007;63:75-82.
19. Reiff DA, Haricharan RN, Bullington NM, et al. Traumatic brain injury is associated with the development of deep vein thrombosis independent of pharmacologic prophylaxis. J Trauma. 2009;66:1436-1440.