Production of hyaluronic acid (HA) nanoparticles by a continuous process inside microchannels: Effects of non-solvents, organic phase flow rate, and HA concentration

Chemical Engineering Science

Volumn 84, Issue , 2012, Pages 134-141

  Bicudo, Rafaela Costa Souza ^a   Santana, Maria Helena Andrade ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Diffusion; Hyaluronic acid; Microfluidics; Nanostructure; Particle formation; Precipitation

Indexed keywords

CARBODIIMIDES; CONTINUOUS PROCESS; CONTROLLED CONDITIONS; CROSS-JUNCTION MICROCHANNEL; CROSSLINKED; DISCONTINUOUS PROCESS; EXPERIMENTAL CONDITIONS; HYALURONIC ACIDS; IMMUNOLOGICAL SYSTEM; INNOVATIVE PROCESS; NANOPRECIPITATION; NEGATIVE ZETA POTENTIALS; NON-SOLVENTS; NON-TOXICITY; OPERATIONAL CONDITIONS; ORGANIC PHASE; PARTICLE FORMATIONS; POTENTIAL APPLICATIONS;

BIODEGRADATION; CHLORINE COMPOUNDS; DIFFUSION; EMULSIFICATION; ETHANOL; FLOW RATE; INNOVATION; LAMINAR FLOW; MICROFLUIDICS; NANOPARTICLES; NANOSTRUCTURES; NATURAL POLYMERS; ORGANIC ACIDS; ORGANIC SOLVENTS; PRECIPITATION (CHEMICAL); ZETA POTENTIAL;

MICROCHANNELS;

EID: 84865859465     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.08.010     Document Type: Article

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