Flow cytometric immunobead assay for fast and easy detection of PML-RARA fusion proteins for the diagnosis of acute promyelocytic leukemia

Leukemia

Volumn 26, Issue 9, 2012, Pages 1976-1985

  Dekking, E H A ^a,b   Van Der Velden, V H J ^a   Varro, R ^c   Wai, H ^c   Bottcher S ^d   Kneba, M ^d   Sonneveld, E ^e   Koning, A ^e   Boeckx, N ^f   Van Poecke, N ^f   Lucio, P ^g   Mendonca A ^g   Sedek, L ^h   Szczepaski, T ^h   Kalina, T ⁱ   Kanderova V ⁱ   Hoogeveen, P ^a   Flores Montero, J ^j   Chillon M C ^j   Orfao, A ^j   Almeida, J ^j   Evans, P ^k   Cullen, M ^k   Noordijk, A L ^a,b   Vermeulen, P M ^a,b   De Man, M T ^a,b   Dixon, E P ^l   Comans Bitter, W M ^a   Van Dongen, J J M ^a   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Dynomics   (Netherlands)

^c BD BIOSCIENCES   (United States)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^g INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^h MEDICAL UNIVERSITY OF SILESIA   (Poland)

ⁱ CHARLES UNIVERSITY   (Czech Republic)

^j CSIC   (Spain)

^k ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^l BD Diagnostics   (United States)

more..

Author keywords

17); APL; flow cytometry; immunobead; PML RARA protein; t(15

Indexed keywords

HYBRID PROTEIN; PHYCOERYTHRIN; RETINOIC ACID;

ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; FLOW CYTOMETRY; FLOW CYTOMETRY IMMUNOBEAD ASSAY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; KARYOTYPE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

ADULT; CASE-CONTROL STUDIES; CHILD; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOASSAY; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 84865854144     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.125     Document Type: Article

References (26)

1. Pandolfi PP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D et al. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. EMBO J 1992; 11: 1397-1407.
2. Grimwade D, Biondi A, Mozziconacci MJ, Hagemeijer A, Berger R, Neat M et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogene-tique Hematologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action 'Molecular Cytogenetic Diagnosis in Haematological Malignancies'. Blood 2000; 96: 1297-1308. (Pubitemid 30658458)
3. Van Dongen JJM, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia 1999; 13: 1901-1928.
4. Walz C, Grimwade D, Saussele S, Lengfelder E, Haferlach C, Schnittger S et al. Atypical mRNA fusions in PML-RARA positive, RARA-PML negative acute promyelocytic leukemia. Genes Chromosomes Cancer 2010; 49: 471-479.
5. Chillon MC, Gonzalez M, Garca-Sanz R, Balanzategui A, Gonzalez D, Lopez-Perez R et al. Two new 3' PML break points in t(15;17)(q22;q21)-positive acute promyelocytic leukemia. Genes Chromosomes Cancer 2000; 27: 35-43.
6. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 1996; 87: 882-886. (Pubitemid 26043517)
7. Grimwade D, Gorman P, Duprez E, Howe K, Langabeer S, Oliver F et al. Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia. Blood 1997; 90: 4876-4885. (Pubitemid 28007201)
8. Hummel JL, Wells RA, Dube ID, Licht JD, Kamel-Reid S. Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia. Oncogene 1999; 18: 633-641. (Pubitemid 29080320)
9. Arnould C, Philippe C, Bourdon V, Gregoire MJ, Berger R, Jonveaux P. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum Mol Genet 1999; 8: 1741-1749. (Pubitemid 29423884)
10. Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of the RARalpha gene in acute promyelocytic leukemia. Oncogene 2001; 20: 7186-7203. (Pubitemid 33105008)
11. Catalano A, Dawson MA, Somana K, Opat S, Schwarer A, Campbell LJ et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007; 110: 4073-4076. (Pubitemid 350248464)
12. Kondo T, Mori A, Darmanin S, Hashino S, Tanaka J, Asaka M. The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia. Haematologica 2008; 93: 1414-1416.
13. Yamamoto Y, Tsuzuki S, Tsuzuki M, Handa K, Inaguma Y, Emi N. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood 2010; 116: 4274-4283.
14. Menezes J, Acquadro F, Perez-Pons de la Villa C, Garca-Sanchez F, Alvarez S, Cigudosa JC. FIP1L1/RARA with break point at FIP1L1 intron 13: a variant translocation in acute promyelocytic leukemia. Haematologica 2011; 96: 1565-1566.
15. Sanz MA, Grimwade D, Tallman MS, Lowenberg B, Fenaux P, Estey EH et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2009; 113: 1875-1891.
16. Tallman MS, Altman JK. How I treat acute promyelocytic leukemia. Blood 2009; 114: 5126-5135.
17. Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF et al. RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia. Proc Natl Acad Sci USA 2007; 104: 18694-18699. (Pubitemid 350210759)
18. Stein E, McMahon B, Kwaan H, Altman JK. Frankfurt O, Tallman MS. The coagulopathy of acute promyelocytic leukaemia revisited. Best Pract Res Clin Haematol 2009; 22: 153-163.
19. Liso V, Bennett J. Morphological and cytochemical characteristics of leukaemic promyelocytes. Best Pract Res Clin Haematol 2003; 16: 349-355.
20. Falini B, Flenghi L, Fagioli M, Lo Coco F, Cordone I, Diverio D et al. Immunocytochemical diagnosis of acute promyelocytic leukemia (M3) with the monoclonal antibody PG-M3 (anti-PML). Blood 1997; 90: 4046-4053. (Pubitemid 27484059)
21. Villamor N, Costa D, Aymerich M, Esteve J, Carrio A, Rozman M et al. Rapid diagnosis of acute promyelocytic leukemia by analyzing the immunocytochemical pattern of the PML protein with the monoclonal antibody PG-M3. Am J Clin Pathol 2000; 114: 786-792. (Pubitemid 33051916)
22. Weerkamp F, Dekking E, Ng YY, Van der Velden VHJ, Wai H, Bottcher S et al. Flow cytometric immunobead assay for the detection of BCR-ABL fusion proteins in leukemia patients. Leukemia 2009; 23: 1106-1117.
23. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R. NB4, a maturation inducible cell line with t(15:17) marker isolated from human acute promyelocytic leukemia (M3). Blood 1991; 77: 1080-1086.
24. Gabert J, Beillard E, Van der Velden VHJ, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program. Leukemia 2003; 17: 2318-2357. (Pubitemid 38072573)
25. Beillard E, Pallisgaard N, Van der Velden VHJ, Bi W, Dee R, Van der Schoot E et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program. Leukemia 2003; 17: 2474-2486. (Pubitemid 38072587)
26. Grimwade D, Jovanovic JV, Hills RK, Nugent EA, Patel Y, Flora R et al. Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. J Clin Oncol 2009; 27: 3650-3658.