Oromucosal midazolam: A guide to its use in paediatric patients with prolonged acute convulsive seizures

CNS Drugs

Volumn 26, Issue 10, 2012, Pages 893-897

  Scott, Lesley J ^a   Lyseng Williamson, Katherine A ^a   Garnock Jones, Karly P ^a  

^a ADIS INTERNATIONAL LIMITED   (New Zealand)

Author keywords

Adis Clinical Q and A; Children; Infants; Midazolam; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ATORVASTATIN; CALCIUM CHANNEL BLOCKING AGENT; CHLORIDE CHANNEL; CYTOCHROME P450 3A4; DIAZEPAM; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; HYPERICUM PERFORATUM EXTRACT; MIDAZOLAM; RIFAMPICIN;

DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG METABOLISM; DRUG TOLERABILITY; HUMAN; HYPERICUM PERFORATUM; MALARIA; PEDIATRICS; PRIORITY JOURNAL; REVIEW; SEIZURE; TREATMENT RESPONSE;

ADMINISTRATION, BUCCAL; ADOLESCENT; CHILD; CHILD, PRESCHOOL; DIAZEPAM; HUMANS; INFANT; MIDAZOLAM; SEIZURES;

EID: 84865849703     PISSN: 11727047     EISSN: 11791934     Source Type: Journal    
DOI: 10.2165/11209350-000000000-00000     Document Type: Review

References (14)

1. Doshi D. Controlling seizures in children: diazepam or midazolam? Systematic review. Hong Kong J Emerg Med 2010; 17 (2): 196-204
2. Offringa M, Newton R. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev 2012; 4: CD003031
3. Tomlin S. Medicines tailored for children: the introduction of buccal midazolam. Pharm J 2011; 287 (7665-7666): 161-2
4. Garnock-Jones KP. Oromuscoal midazolam: a review of its use in pediatric patients with prolonged acute convulsive seizures. Pediatr Drugs 2012; 14 (4): 251-261
5. Body R, Ijaz M. Best evidence topic report: buccal midazolam as an alternative to rectal diazepam for prolonged seizures in childhood and adolescence. Emerg Med J 2005; 22 (5): 364-5
6. National Clinical Guideline Centre. The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care (pharmacological update of Clinical Guideline 20) [online]. Available from URL: http://www.nice.org.uk/nicemedia/live/13635/57784/57784.pdf [Accessed 2012 Mar 5]
7. Buccolam oromucosal solution: summary of product characteristics. London: EuropeanMedicinesAgency, 2011 Sep 19
8. Scott RC, Besag FMC, Neville BGR. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet 1999; 353 (9153): 623-6
9. McIntyre J, Robertson S, Norris E, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet 2005; 366 (9481): 205-10
10. Mpimbaza A, Ndeezi G, Staedke S, et al. Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics 2008; 121 (1): e58-64
11. Talukdar B, Chakrabarty B. Efficacy of buccal midazolam compared to intravenous diazepam in controlling convulsions in children: a randomized controlled trial. Brain Dev 2009; 31 (10): 744-9
12. McMullan J, Sasson C, Pancioli A, et al. Midazolam versus diazepam for the treatment of status epilepticus in children and young adults: a meta-analysis. Acad Emerg Med 2010; 17 (6): 575-82
13. Baysun S, Aydin Ö F, Atmaca E, et al. A comparison of buccal midazolam and rectal diazepam for the acute treatment of seizures. Clin Pediatr 2005; 44 (9): 771-6
14. Buccolam (midazolam): European public assessment report. London: European Medicines Agency, 2011 Sep 19