Modulation of smooth muscle cell phenotype: The other side of the story

Circulation Research

Volumn 111, Issue 6, 2012, Pages 659-661

  Huang, Jianhe ^a   Parmacek, Michael S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CArG element; myocardin; serum response factor; smooth muscle cells; transcription regulation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; HISTONE DEACETYLASE 2; MADS DOMAIN PROTEIN; MICRORNA 143; MICRORNA 145; MYOCARDIN; PLATELET DERIVED GROWTH FACTOR; SERUM RESPONSE FACTOR;

BINDING KINETICS; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL ULTRASTRUCTURE; CHROMATIN IMMUNOPRECIPITATION; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; HUMAN; MOLECULAR DYNAMICS; MUSCLE CONTRACTION; NEURAL CREST CELL; NONHUMAN; OXIDATION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ETS-DOMAIN PROTEIN ELK-1; HISTONE DEACETYLASE 2; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MYOCYTES, SMOOTH MUSCLE; PROMOTER REGIONS, GENETIC;

EID: 84865844838     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.277368     Document Type: Review

References (17)

1. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801.
2. Mack CP. Signaling mechanisms that regulate smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol. 2011;31:1495-1505.
3. Parmacek MS. Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation. Circ Res. 2007;100:633-644.
4. Pipes GC, Creemers EE, Olson EN. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev. 2006;20:1545-1556.
5. Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol. 2003;23:2425-2437.
6. Li S, Wang DZ, Wang Z, Richardson JA, Olson EN. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci USA. 2003;100:9366-9370.
7. Huang J, Cheng L, Li J, Chen M, Zhou D, Lu MM, Proweller A, Epstein JA, Parmacek MS. Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest. 2008;118:515-525.
8. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004;428:185-189.
9. Haldar SM, Ibrahim OA, Jain MK. Kruppel-like factors (KLFs) in muscle biology. J Mol Cell Cardiol. 2007;43:1-10.
10. Liu Y, Sinha S, McDonald OG, Shang Y, Hoofnagle MH, Owens GK. Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J Biol Chem. 2005;280:9719-9727.
11. McDonald OG, Owens GK. Programming smooth muscle plasticity with chromatin dynamics. Circ Res. 2007;100:1428-1441.
12. Albinsson S, Sessa WC. Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genom. 2011; 43:529-533.
13. Caruso P, Dempsie Y, Stevens H, et al. A role for mir-145 in pulmonary arterial hypertension. Circ Res. 2012;111:290-300.
14. Wamhoff BR, Hoofnagle MH, Burns A, Sinha S, McDonald OG, Owens GK. A g/c element mediates repression of the sm22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ Res. 2004;95:981-988.
15. Regan CP, Adam PJ, Madsen CS, Owens GK. Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury. J Clin Invest. 2000;106:1139-1147.
16. Salmon M, Gomez D, Greene E, Shankman L, Owens GK. Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22-promoter mediates transcriptional silencing during SMC phenotypic switching in vivo. Circ Res. 2012;111:685-696.
17. Chang CP, Bruneau BG. Epigenetics and cardiovascular development. Annu Rev Physiol. 2012;74:41-68.