Poor absorption of high-dose posaconazole in pediatric bone marrow transplant patients

Annals of Pharmacotherapy

Volumn 46, Issue 9, 2012, Pages

  Matthias Dr , Kathryn R ^a   Nix, David E ^a   Peloquin, Charles A ^b,c   Graham, Michael L ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b Department of Pharmacotherapy and Translational Research ^*  (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Absorption; Bone marrow transplant; Mucormycosis; Posaconazole

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; BUSULFAN; CASPOFUNGIN; CYCLOPHOSPHAMIDE; FAMOTIDINE; HEMOSIDERIN; ITRACONAZOLE; MELPHALAN; MICAFUNGIN; PHENYTOIN; POSACONAZOLE; SUCRALFATE; VORICONAZOLE;

ADULT RESPIRATORY DISTRESS SYNDROME; ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BRAIN DAMAGE; CANCER RELAPSE; CASE REPORT; CHILD; COMPUTER ASSISTED TOMOGRAPHY; CONGESTIVE HEART FAILURE; CONTINUOUS HEMODIAFILTRATION; DEBRIDEMENT; DRUG ABSORPTION; DRUG MEGADOSE; DRUG WITHDRAWAL; ENCEPHALITIS; ENTERIC FEEDING; FACE INJURY; FUNGUS ISOLATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LACUNAR STROKE; LIVER CONGESTION; LOW DRUG DOSE; LYMPHATIC LEUKEMIA; MALE; MAXILLA SINUSITIS; MUCORMYCOSIS; NAUSEA AND VOMITING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; ORBIT CELLULITIS; ORBIT TUMOR; PARANASAL SINUS DISEASE; PARANASAL SINUSITIS; PARENTERAL NUTRITION; PRESCHOOL CHILD; PRIORITY JOURNAL; RHIZOPUS; RHIZOPUS ARRHIZUS; SCHOOL CHILD; SEIZURE; TELEMETRY; WEIGHT REDUCTION; WHOLE BODY RADIATION;

ABSORPTION; ANTIFUNGAL AGENTS; BONE MARROW TRANSPLANTATION; CHILD; HUMANS; INFANT; MALE; MYCOSES; TRIAZOLES;

EID: 84865842791     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1Q456     Document Type: Article

References (13)

1. Krishna G, Sansone-Parsons A, Martinho M, et al. Posaconazole plasma concentrations in juvenile patients with invasive fungal infection. Antimicrob Agents Chemother 2007;51:812-8.
2. Greenberg RN, Mullane K, van Burik JAH, et al. Posaconazole as salvage therapy for zygomycosis. Antimicrob Agents Chemother 2006;50: 126-33.
3. Raad II, Graybill JR, Bustamante AB, et al. Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections. Clin Infect Dis 2006;42:1726-34.
4. Ascioglu S, Rex JH, Bennett JE, et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002;34:7-14.
5. Ezzet F, Wexler D, Courtney R, et al. Oral bioavailability of posaconazole in fasted healthy subjects: comparison between three regimens and basis for clinical dosage recommendations. Clin Pharmacokinet 2005;44: 211-20.
6. Courtney R, Pai D, Laughlin M, et al. Pharmacokinetics, safety and tolerability of oral posaconazole administered in single and multiple doses in healthy adults. Antimicrob Agents Chemother 2003;47:2788-95.
7. Product information. Noxadil (posaconazole) oral suspension. Kenilworth, NJ: Schering-Plough, June 2008.
8. Hussaini T, Rüping MJ, Farowski F, et al. Therapeutic drug monitoring of voriconazole and posaconazole. Pharmacotherapy 2011;31:21-5.
9. Ashley ESD, Varkey JB, Krishna G, et al. Pharmacokinetics of posaconazole administered orally or by nasogastric tube in healthy volunteers. Antimicrob Agents Chemother 2009;53:2960-4.
10. Krishna G, Moton A, Medloack MM, et al. Pharmacokinetics and absorption of posaconazole oral suspension under various gastric conditions in healthy volunteers. Antimicrob Agents Chemother 2009;53:958-66.
11. Shields RK, Clancy CJ, Vadnerkar A, et al. Posaconazole serum concentrations among cardiothoracic transplant recipients: factors impacting trough levels and correlation with clinical response to therapy. Antimicrob Agents Chemother 2011;55:1308-11.
12. Abuali MM, Posada R, Del Toro G, et al. Rhizomucor variabilis var. regularior and Hormographiella aspergillata infections in a leukemic bone marrow transplant recipient with refractory neutropenia. J Clin Microbiol 2009;47:4176-9.
13. Tarani L, Costantino F, Nothesis G, et al. Long-term posaconazole treatment and follow-up of rhino-orbital-cerebral mucormycosis in a diabetic girl. Pediatr Diabetes 2009;10:289-93.