Effects on arrhythmogenesis and arrhythmic threshold of injection of autologous fibroblasts into myocardial infarcts in adult pigs

Journal of Cardiovascular Translational Research

Volumn 5, Issue 3, 2012, Pages 337-344

  Tondato, Fernando ^a   Robinson, Keith ^a   Cui, Jianhua ^a   Goodchild, Traci ^a   Chronos, Nicolas ^a   Peters, Nicholas S ^a,b  

^a Saint Joseph's Translational Research Institute   (United States)

^b ST MARY S HOSPITAL   (United Kingdom)

Author keywords

Arrhythmia; Fibroblast; Infarction; Myocardium; Ventricular

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; AUTOLOGOUS DERMAL FIBROBLAST TRANSPLANTATION; AUTOTRANSPLANTATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; ELECTROCARDIOGRAM; ENGRAFTMENT; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HISTOLOGY; NONHUMAN; PRIORITY JOURNAL; SKIN FIBROBLAST; SWINE; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; ELECTROCARDIOGRAPHY; FIBROBLAST; HEART MUSCLE; HEART PACING; INJECTION; PATHOLOGY; PATHOPHYSIOLOGY; SKIN; TIME; TRANSPLANTATION;

ANIMALIA; SUIDAE;

ANIMALS; CARDIAC PACING, ARTIFICIAL; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY, AMBULATORY; FIBROBLASTS; INJECTIONS; MYOCARDIAL INFARCTION; MYOCARDIUM; SKIN; SWINE; TACHYCARDIA, VENTRICULAR; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS;

EID: 84865840225     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-011-9316-9     Document Type: Article

References (24)

1. Chachques, J. C., Shafy, A., Duarte, F., Cattadori, B., Goussef, N., Shen, L., et al. (2002). From dynamic to cellular cardiomyoplasty. Journal of Cardiac Surgery, 17(3), 194-200. (Pubitemid 35440933)
2. Dib, N., Diethrich, E. B., Campbell, A., Goodwin, N., Robinson, B., Gilbert, J., et al. (2002). Endoventricular transplantation of allogenic skeletal myoblasts in a porcine model of myocardial infarction. Journal of Endovascular Therapy, 9(3), 313-319. (Pubitemid 34791395)
3. Ghostine, S., Carrion, C., Souza, L. C., Richard, P., Bruneval, P., Vilquin, J. T., et al. (2002). Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction. Circulation, 106(12 Suppl 1), I131-I136.
4. Menasche, P. (2003). Cell transplantation in myocardium. The Annals of Thoracic Surgery, 75(6 Suppl), S20-S28. (Pubitemid 36677186)
5. Menasche, P. (2005). Stem cells for clinical use in cardiovascular medicine: Current limitations and future perspectives. Thrombosis and Haemostasis, 94(4), 697-701. (Pubitemid 41508726)
6. Menasche, P., Hagege, A. A., Scorsin, M., Pouzet, B., Desnos, M., Duboc, D., et al. (2001). Myoblast transplantation for heart failure. Lancet, 357(9252), 279-280. (Pubitemid 32120862)
7. Menasche, P., Hagege, A. A., Vilquin, J. T., Desnos, M., Abergel, E., Pouzet, B., et al. (2003). Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. Journal of the American College of Cardiology, 41(7), 1078-1083. (Pubitemid 36384891)
8. Menasche, P., Alfieri, O., Janssens, S., McKenna,W., Reichenspurner, H., Trinquart, L., et al. (2008). The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebocontrolled study of myoblast transplantation. Circulation, 117(9), 1189-1200. (Pubitemid 351552018)
9. Smith, R. R., Barile, L., Messina, E., & Marban, E. (2008). Stem cells in the heart: What's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm, 5(6), 880-887.
10. Yankelson, L., Feld, Y., Bressler-Stramer, T., Itzhaki, I., Huber, I., Gepstein, A., et al. (2008). Cell therapy for modification of the myocardial electrophysiological substrate. Circulation, 117(6), 720-731. (Pubitemid 351640673)
11. Menasche, P. (2009). Stem cell therapy for heart failure: Are arrhythmias a real safety concern? Circulation, 119(20), 2735-2740.
12. Dib, N., Menasche, P., Bartunek, J. J., Zeiher, A. M., Terzic, A., Chronos, N. A., et al. (2010). Recommendations for successful training on methods of delivery of biologics for cardiac regeneration: A report of the International Society for Cardiovascular Translational Research. JACC Cardiovascular Interventions, 3(3), 265-275.
13. Menasche, P. (2002). Myoblast transplantation: feasibility, safety and efficacy. Annals of Medicine, 34(5), 314-315. (Pubitemid 35351820)
14. Eghbali, M. (1992). Cardiac fibroblasts: function, regulation of gene expression, and phenotypic modulation. Basic Research in Cardiology, 87(Suppl 2), 183-189. (Pubitemid 23081268)
15. Etzion, S., Barbash, I. M., Feinberg, M. S., Zarin, P., Miller, L., Guetta, E., et al. (2002). Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: An unlimited source of cells for myocardial repair. Circulation, 106(12 Suppl 1), I125-I130.
16. Gaudesius, G., Miragoli, M., Thomas, S. P., & Rohr, S. (2003). Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circulation Research, 93 (5), 421-428. (Pubitemid 37100007)
17. Ho, K. K., Anderson, K. M., Kannel, W. B., Grossman, W., & Levy, D. (1993). Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation, 88(1), 107-115. (Pubitemid 23195439)
18. Peters, N. S. (2005). Arrhythmias after cell transplantation for myocardial regeneration: natural history or result of the intervention? Journal of Cardiovascular Electrophysiology, 16 (11), 1255-1257.
19. Peters, N. S., Coromilas, J., Severs, N. J., & Wit, A. L. (1997). Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation, 95(4), 988-996. (Pubitemid 27091545)
20. Hagege, A. A., Marolleau, J. P., Vilquin, J. T., Alheritiere, A., Peyrard, S., Duboc, D., et al. (2006). Skeletalmyoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients. Circulation, 114(1 Suppl), I108-I113. (Pubitemid 44297137)
21. Wollert, K. C., Meyer, G. P., Lotz, J., Ringes-Lichtenberg, S., Lippolt, P., Breidenbach, C., et al. (2004). Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial. Lancet, 364(9429), 141-148. (Pubitemid 38891685)
22. Schachinger, V., Tonn, T., Dimmeler, S., & Zeiher, A. M. (2006). Bone-marrow-derived progenitor cell therapy in need of proof of concept: design of the REPAIR-AMI trial. Nature Clinical Practice, 3(Suppl 1), S23-S28.
23. Reinecke, H., MacDonald, G. H., Hauschka, S. D., & Murry, C. E. (2000). Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. The Journal of Cell Biology, 149(3), 731-740. (Pubitemid 30252405)
24. Long, C. S., & Brown, R. D. (2002). The cardiac fibroblast, another therapeutic target for mending the broken heart? Journal of Molecular and Cellular Cardiology, 34(10), 1273-1278. (Pubitemid 35244400)