Testosterone, HDL and cardiovascular risk in men: The jury is still out

Clinical Lipidology

Volumn 7, Issue 4, 2012, Pages 363-365

  Rubinow, Katya B ^a   Page, Stephanie T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

androgens; cardiovascular disease; cholesterol; HDL; testosterone

Indexed keywords

AROMATASE INHIBITOR; ESTRADIOL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; NITRIC OXIDE; TESTOSTERONE; TORCETRAPIB;

ANDROGEN THERAPY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL TRANSPORT; ENZYME ACTIVITY; HUMAN; HYPOGONADISM; OBESITY; PLEIOTROPY; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; QUALITY OF LIFE; REVIEW; RISK FACTOR; STAMEN;

EID: 84865838306     PISSN: 17460875     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.12.38     Document Type: Review

References (20)

1. Srinivas-Shankar U, Roberts SA, Connolly MJ et al. Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study. J. Clin. Endocrinol. Metab. 95, 639-650 (2010).
2. Shabsigh R, Katz M, Yan G, Makhsida N. Cardiovascular issues in hypogonadism and testosterone therapy. Am. J. Cardiol. 96, M67-M72 (2005).
3. Basaria S. Androgen abuse in athletes: detection and consequences. J. Clin. Endocrinol. Metab. 95, 1533-1543 (2010).
4. Ozata M, Yildirimkaya M, Bulur M et al. Effects of gonadotropin and testosterone treatments on lipoprotein(a), high density lipoprotein particles, and other lipoprotein levels in male hypogonadism. J. Clin. Endocrinol. Metab. 81, 3372-3378 (1996).
5. Rubinow KB, Vaisar T, Tang C et al. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J. Lipid Res. 53(7), 1376-1383 (2012).
6. Amory JK, Kalhorn TF, Page ST. Pharmacokinetics and pharmacodynamics of oral testosterone enanthate plus dutasteride for 4 weeks in normal men: implications for male hormonal contraception. J. Androl. 29, 260-271 (2008).
7. Bagatell CJ, Knopp RH, Rivier JE, Bremner WJ. Physiological levels of estradiol stimulate plasma high density lipoprotein 2 cholesterol levels in normal men. J. Clin. Endocrinol. Metab. 78, 855-861 (1994).
8. Friedl KE, Hannan CJ Jr, Jones RE, Plymate SR. High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. Metabolism 39, 69-74 (1990).
9. Boden WE. High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the veterans affairs high - density lipoprotein intervention trial. Am. J. Cardiol. 86, 19L-22L (2000).
10. Barter PJ, Caulfield M, Eriksson M et al. Effects of torcetrapib in patients at high risk for coronary events. N. Engl. J. Med. 357, 2109-2122 (2007).
11. Keating NL, O'Malley AJ, Freedland SJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. J. Natl Cancer Inst. 102, 39-46 (2010).
12. Khera AV, Cuchel M, de la Llera-Moya M et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N. Engl. J. Med. 364, 127-135 (2011).
13. de la Llera-Moya M, Drazul-Schrader D, Asztalos BF et al. The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler. Thromb. Vasc. Biol. 30, 796-801 (2010).
14. Langer C, Gansz B, Goepfert C et al. Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages. Biochem. Biophys. Res. Commun. 296, 1051-1057 (2002).
15. Besler C, Heinrich K, Rohrer L et al. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J. Clin. Invest. 121, 2693-2708 (2011).
16. Gordon SM, Hofmann S, Askew DS, Davidson WS. High density lipoprotein: it's not just about lipid transport anymore. Trends Endocrinol. Metab. 22, 9-15 (2010).
17. Laughlin GA, BarrettConnor E, Bergstrom J. Low serum testosterone and mortality in older men. J. Clin. Endocrinol. Metab. 93, 68-75 (2008).
18. Vikan T, Johnsen SH, Schirmer H et al. Endogenous testosterone and the prospective association with carotid atherosclerosis in men: the Tromsø study. Eur. J. Epidemiol. 24, 289-295 (2009).
19. Shahani S, Braga-Basaria M, Basaria S. Androgen deprivation therapy in prostate cancer and metabolic risk for atherosclerosis. J. Clin. Endocrinol. Metab. 93, 2042-2049 (2008).
20. Basaria S, Coviello AD, Travison TG et al. Adverse events associated with testosterone administration. N. Engl. J. Med. 363, 109-122 (2010).