Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target.

PloS one

Volumn 7, Issue 4, 2012, Pages

  Eadsforth, Thomas C ^a   Gardiner, Mary ^b   Maluf, Fernando V ^b   McElroy, Stuart ^b   James, Daniel ^b   Frearson, Julie ^b   Gray, David ^b   Hunter, William N ^b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; LIGAND; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE;

ARTICLE; BIOASSAY; BIOCATALYSIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGICAL EXAMINATION; PROTEIN SECONDARY STRUCTURE; PSEUDOMONAS AERUGINOSA; REPRODUCIBILITY; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BIOCATALYSIS; BIOLOGICAL ASSAY; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; MICROBIAL SENSITIVITY TESTS; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS AERUGINOSA; REPRODUCIBILITY OF RESULTS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84865832712     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035973     Document Type: Article

References (0)