Outcomes of positive randomised controlled clinical trials: Double-blind or double vision?

Thrombosis and Haemostasis

Volumn 108, Issue 3, 2012, Pages 410-411

  Verheugt, Freek W A ^a  

^a Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PRASUGREL; ROSIGLITAZONE; TICAGRELOR;

ACUTE CORONARY SYNDROME; ARTICLE; CLINICAL PRACTICE; DIABETES MELLITUS; DRUG APPROVAL; FOOD AND DRUG ADMINISTRATION; HEART INFARCTION; HUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; PUBLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESEARCH; TRANSIENT ISCHEMIC ATTACK;

ACUTE CORONARY SYNDROME; CLINICAL TRIALS, PHASE III AS TOPIC; HUMANS; MULTICENTER STUDIES AS TOPIC; MYOCARDIAL INFARCTION; OUTCOME ASSESSMENT (HEALTH CARE); PROCESS ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84865806634     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-06-0435     Document Type: Article

References (9)

1. Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356: 2457-2471.
2. Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009; 373:2125-2135.
3. Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl JMed 2007; 357:2001-2015.
4. Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-1057.
5. Serebruany VL, Atar D. Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials: common patterns in TRITON, RECORD and PLATO. Thromb Haemost 2012; 108: 412-414.
6. Serebruany VL. Viewpoint: paradoxical excess mortality in the PLATO trial should be independently verified. Thromb Haemost 2011; 105: 752-759.
7. Wallentin L, Becker RC, James SK, et al. The PLATO trial reveals further opportunities to improve outcomes in patients with acute coronary syndrome. Thromb Haemost 2011; 105: 760-762.
8. Ohman EM, Roe MT Explaining the unexpected: insights from the PLATelet inhibition and clinical Outcomes (PLATO) trial comparing ticagrelor and clopidogrel. Thromb Haemost 2011; 105:763-765.
9. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525-2538.