1,4-Addition of an aryllithium reagent to diethyl ketomalonate. Scalable synthesis of ethyl 1-(hydroxymethyl)-1,3-dihydroisobenzofuran-1-carboxylate

Tetrahedron Letters

Volumn 53, Issue 41, 2012, Pages 5467-5470

  Rocke, Benjamin N ^a   Conn, Edward L ^a   Eisenbeis, Shane A ^a   Ruggeri, Roger B ^a  

^a PFIZER INC   (United States)

Author keywords

1,4 Addition; Annulation; Diethyl ketomalonate; Directed ortho metalation; Mono reduction

Indexed keywords

BENZALDEHYDE; DIETHYL KETOMALONATE; ETHYL 1 (HYDROXYMETHYL) 1,3 DIHYDROISOBENZOFURAN 1 CARBOXYLATE; KETONE; LITHIUM; LITHIUM TRI TERT BUTOXYALUMINUM HYDRIDE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANNULATION REACTION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; METALLATION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STOICHIOMETRY; SYNTHESIS;

EID: 84865803541     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.05.052     Document Type: Article

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