Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway

Molecular Nutrition and Food Research

Volumn 56, Issue 9, 2012, Pages 1477-1481

  Tuzcu, Mehmet ^a   Aslan, Abdullah ^a   Tuzcu, Zeynep ^a   Yabas, Mehmet ^b   Bahcecioglu, Ibrahim Halil ^a   Ozercan, Ibrahim Hanifi ^a   Kucuk, Omer ^c   Sahin, Kazim ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b Biology and Environment   (Australia)

^c EMORY UNIVERSITY   (United States)

Author keywords

Colorectal cancer; Cyclooxygenase 2; NF B; Oxidative stress; Tomato powder

Indexed keywords

ANTINEOPLASTIC AGENT; AZOXYMETHANE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFE2L2 PROTEIN, RAT; PLANT EXTRACT; PTGS2 PROTEIN, RAT; TRANSCRIPTION FACTOR NRF2;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLORECTAL TUMOR; DRUG EFFECT; GENETICS; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; RAT; SIGNAL TRANSDUCTION; TOMATO; UPREGULATION; WISTAR RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; AZOXYMETHANE; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; LYCOPERSICON ESCULENTUM; NF-E2-RELATED FACTOR 2; NF-KAPPA B; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UP-REGULATION;

LYCOPERSICON ESCULENTUM; RATTUS; RATTUS NORVEGICUS;

EID: 84865798436     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200130     Document Type: Article

References (23)

1. Sung, J. J., Lau, J. Y., Goh, K. L., Leung, W. K., Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 2005, 6, 871-876.
2. Miller, P. E., Lesko, S. M., Muscat, J. E., Lazarus, P. et al., Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence. Nutr. Cancer 2010, 62, 413-424.
3. Seren, S., Lieberman, R., Bayraktar, U. D., Heath, E. et al., Lycopene in cancer prevention and treatment. Am J. Ther 2008, 15, 66-81.
4. Sahin, K., Sahin, N., Kucuk, O., Lycopene and chemotherapy toxicity. Nutr. Cancer 2010, 62, 988-995.
5. Palozza, P., Parrone, N., Simone, R., Catalano, A., Role of lycopene in the control of ROS-mediated cell growth: implications in cancer prevention. Curr. Med. Chem. 2011, 18, 1846-1860.
6. Kelkel, M., Schumacher, M., Dicato, M., Diederich, M., Antioxidant and anti-proliferative properties of lycopene. Free Radic. Res. 2011, 45, 925-940.
7. Walfisch, S., Walfisch, Y., Kirilov, E., Linde, N. et al., Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur. J. Cancer Prev. 2007, 16, 298-303.
8. Tang, F. Y., Shih, C. J., Cheng, L. H., Ho, H. J.et al., Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway. Mol. Nutr. Food Res. 2008, 52, 646-654.
9. Palozza, P., Colangelo, M., Simone, R., Catalano, A. et al., Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis 2010, 31, 1813-1821.
10. Boileau, T. W., Liao, Z., Kim, S., Lemeshow, S. et al., Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J. Natl. Cancer Inst. 2003, 95, 1578-1586.
11. Alshatwi, A. A., Al Obaaid, M. A., Al Sedairy, S. A., Al-Assaf, A. H. et al., Tomato powder is more protective than lycopene supplement against lipid peroxidation in rats. Nutr. Res. 2010, 30, 66-73.
12. Tanaka, T., Colorectal carcinogenesis: review of human and experimental animal studies. J. Carcinog. 2009, 8, 5.
13. Dannenberg, A. J., Altorki, N. K., Boyle, J. O., Dang, C. et al., Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol. 2001, 2, 544-551.
14. Wang, D., Dubois, R. N., The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 2010, 29, 781-788.
15. Ghosh, N., Chaki, R., Mandal, V., Mandal, S. C., COX-2 as a target for cancer chemotherapy. Pharmacol. Rep. 2010, 62, 233-244.
16. Lind, D. S., Hochwald, S. N., Malaty, J., Rekkas, S. et al., Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery 2001, 130, 363-369.
17. Hardwick, J. C., van den Brink, G. R., Offerhaus, G. J., van Deventer, S. J. et al., NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 2001, 20, 819-827.
18. Karin, M., Cao, Y., Greten, F. R., Li, Z. W., NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2, 301-310.
19. Sies, H., Masumoto, H., Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite. Adv. Pharmacol. 1997, 38, 229-246.
20. Sriram, N., Kalayarasan, S., Sudhandiran, G., Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2-Keap1 signaling. Pulm. Pharmacol. Ther. 2009, 22, 221-236.
21. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H. et al., Curcu-min attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem. Toxicol. 2008, 46, 1279-1287.
22. Kim, J., Cha, Y. N., Surh, Y. J., A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 2010, 690, 12-23.
23. Giudice, A., Montella, M., Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. Bioessays 2006, 28, 169-181.