A novel LC-MS/MS method for simultaneous quantification of tenofovir and lamivudine in human plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 26, Issue 10, 2012, Pages 1202-1209

  Matta, Murali Krishna ^a   Burugula, Laxminarayana ^a   Pilli, Nageswara Rao ^a   Inamadugu, Jaswanth Kumar ^b   Jvln, Seshagiri Rao ^c  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b SRI VENKATESWARA UNIVERSITY   (India)

^c ANDHRA UNIVERSITY   (India)

Author keywords

Lamivudine; LC MS MS; Method validation; Pharmacokinetics; Tenofovir

Indexed keywords

EXTRACTION; PHARMACOKINETICS; PHASE SEPARATION; PLASMA (HUMAN);

ABACAVIR; HUMAN PLASMAS; INTERNAL STANDARDS; ITS APPLICATIONS; LAMIVUDINE; LC-MS-MS; LC.MS/MS; METHOD VALIDATIONS; PHARMACOKINETIC STUDIES; TENOFOVIR;

ELECTROSPRAY IONIZATION;

ABACAVIR; ACETONITRILE; FORMIC ACID; LAMIVUDINE; TENOFOVIR; WATER;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; DRUG BLOOD LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; PLASMA CONCENTRATION-TIME CURVE; SOLID PHASE EXTRACTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84865784336     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2679     Document Type: Article

References (24)

1. Carpenter CCJ, Fischl MA and Hammer SM. Antiretroviral therapy for HIV infection in 1997. Updated Recommendations of the International AIDS Society-USA Panel. Journal of the American Medical Association 1997; 277: 962-969.
2. Cavert W, Notermans DW and Staskus K. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997; 276: 960-964.
3. Chantelle BH, Mary LC and Edward PA. Development of a sensitive and specific liquid chromatography/mass spectrometry method for the determination of tenofovir in human plasma. Rapid Communications in Mass Spectrometry 2007; 21: 2087-2094.
4. Chapman T, McGavin J and Noble S. Tenofovir disoproxil fumarate. Drugs 2003; 63: 1597-1608.
5. Chesney M. Adherence to HAART regimen. AIDS Patient Care and STDs 2003; 17: 169.
6. Colombo S, Guignard N, Marzolini C, Telenti A, Biollaz J and Decosterd LA. Determination of new HIV protease inhibitor atazanavir by liquid chromatography after solid phase extraction. Journal of Chromatography B 2004; 810: 25-34.
7. Dailly E, Raffi F and Jollet P. Determination of atazanavir and other antiretroviral drugs (indinavir, amprenavir, nelfinavir and its active metabolite M8, saquinavir, ritonavir, lopinavir, nevirapine and efavirenz) plasma levels by high performance liquid chromatography with UV detection. Journal of Chromatography B 2004; 813: 353-358.
8. Delahunty T, Bushman L and Fletcher CV. Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS. Journal of Chromatography B 2006; 830: 6-12.
9. Gallant JE. Initial therapy of HIV infection. Journal of Clinical Virology 2002; 25: 317-333.
10. Gulick RM, Mellors JM and Havlir D. Treatment with indinavir, zidovudine and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. The New England Journal of Medicine 1997; 337: 734-739.
11. Gurtman A, Borrego F and Koltman ME. Management of antiretroviral therapy. Seminars in Nephrology 1998; 18: 459-480.
12. Harker AJ, Evans GL, Hawky AE and Morris DM. High performance liquid chromatographic assay for 2'-deoxy-3'-thiacytidine in human serum. Journal of Chromatography B 1994; 657: 227-232.
13. Hoetelmans RM, Profijit M, Mennhornst PL, Mulder JW and Beijnen JH. Quantitative determination of (-)-2'-deoxy3'-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography B 1998; 713: 387-394.
14. Jullein V, Treluyer JM, Pons G and Rey E. Determination of tenofovir in human plasma by high performance liquid chromatography with spectroflurometic detection. Journal of Chromatography B 2003; 785: 377-381.
15. King T, Bushman L, Kiser J, Anderson PL, Ray M, Delahunty T and Fletcher CV. Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells. Journal of Chromatography B 2006; 843: 147-156.
16. Morris DM and Selinger K. Determination of 2'-deoxy-3'-thiacytidine (3TC) in human urine by liquid chromatography: direct injection with column switching. Journal of Pharmaceutical and Biomedical Analysis 1994; 12: 255-264.
17. Rezk NL, Tidwell RR and Kashuba AD. High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma. Journal of Chromatography B 2004; 805: 241-247.
18. Schmutz G, Nelson M, Lutz T, Sheldon J, Bruno R, Florian B, Hoffmann C, Rockstroh J, Stoehr A, Wolf E, Soriano V, Berger F, Berg T, Carlebach A, Zander SC, Schumann D, Jaaeger H and Mauss S. Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection. AIDS 2006; 20: 1951-1954.
19. Sentenac S, Fernandez C, Thullier A, Lechat P and Aymard G. Sensitive determination of tenofovir in human plasma samples using reverse phase liquid chromatography. Journal of Chromatography B 2003; 793: 317-324.
20. Takahashi M, Kudaka Y, Okumura N, Hirano A, Banno K and Kaneda T. Determination of plasma tenofovir concentrations using a conventional LC-MS method. Biological and Pharmaceutical Bulletin 2007; 30: 1784-1786.
21. US DHHS, FDA, CDER and CVM. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research and Center for Veterinary Medicine, 2001. Available at: http://www/fda.gov/cder/guidance/index.htm
22. Verweij CP, Aarnoutse RE and Burger DM. Simultaneous determination of the HIV nucleoside analogue reverse transcriptase inhibitors lamivudine, didanosine, stavudine, zidovudine and abacavir in human plasma by reversed phase high performance liquid chromatography. Journal of Chromatography B 2005; 816: 121-129.
23. Yarchoan R, Mitsuya H, Myers CE and Broder SN. Drug therapy; clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides. The New England Journal of Medicine 1989; 321: 726-738.
24. Zhou XJ and Sommadosi JP. Rapid Quantitation of (-)-2'-deoxy-3'- thiacytidine in human serum by high-performance liquid chromatography with ultraviolet detection. Journal of Chromatography B 1997; 691: 417-424.