Novel non-coding RNA-based therapeutic approaches to prevent statin-induced liver damage

EMBO Molecular Medicine

Volumn 4, Issue 9, 2012, Pages 863-865

  Bang, Claudia ^a   Thum, Thomas ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Cholesterol; Hepatotoxicity; MiRNAs; Statins; Sterol transporters

Indexed keywords

ABC TRANSPORTER G1; ADENOSINE TRIPHOSPHATASE; ATP8B1 PROTEIN; CARRIER PROTEIN; CHOLESTEROL; FARNESOID X RECEPTOR; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LIVER X RECEPTOR; MESSENGER RNA; MICRORNA; MICRORNA 33; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CELL MEMBRANE; CELL PROLIFERATION; CHOLESTEROL METABOLISM; GENE CONTROL; GENE EXPRESSION; GENE SILENCING; HUMAN; IN VIVO STUDY; LIVER CELL; LIVER REGENERATION; NONHUMAN; NOTE; PRIORITY JOURNAL; RNA DEGRADATION; SIGNAL TRANSDUCTION; TOXIC HEPATITIS;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; GENE EXPRESSION REGULATION; MALE; MICRORNAS;

EID: 84865773208     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201201565     Document Type: Note

References (16)

1. Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ.-H, Ananthanarayanan M, Ford DA, Baldán A (2012) miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. EMBO Mol Med DOI: 10.1002/emmm.201201228.
2. Beaven SW, Tontonoz P (2006) Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med 57: 313-329.
3. Cirera-Salinas D, Pauta M, Allen RM, Salerno AG, Ramirez CM, Chamorro-Jorganes A, Wanschel AC, Lasuncion MA, Morales-Ruiz M, Suarez Y et al (2012) Mir-33 regulates cell proliferation and cell cycle progression. Cell Cycle 11: 5.
4. Davalos A, Goedeke L, Smibert P, Ramirez CM, Warrier NP, Andreo U, Cirera-Salinas D, Rayner K, Suresh U, Pastor-Pareja JC et al (2011) miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci USA 108: 9232-9237.
5. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y et al (2010) MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Proc Natl Acad Sci USA 107: 17321-17326.
6. Khanuja B, Cheah YC, Hunt M, Nishina PM, Wang DQ, Chen HW, Billheimer JT, Carey MC, Paigen B (1995) Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice. Proc Natl Acad Sci USA 92: 7729-7733.
7. Marquart TJ, Allen RM, Ory DS, Baldan A (2010) miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA 107: 12228-12232.
8. Moore KJ, Rayner KJ, Suarez Y, Fernandez-Hernando C (2011) The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr 31: 49-63.
9. Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Naar AM (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328: 1566-1569.
10. Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernandez-Hernando C (2010) MiR-33 contributes to the regulation of cholesterol homeostasis. Science 328: 1570-1573.
11. Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X et al (2011a) Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 478: 404-407.
12. Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y et al (2011b) Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest 121: 2921-2931.
13. Thum T (2012) MicroRNA therapeutics in cardiovascular medicine. EMBO Mol Med 4: 3-14.
14. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A et al (2007) MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116: 258-267.
15. Wang X, Rader DJ (2007) Molecular regulation of macrophage reverse cholesterol transport. Curr Opin Cardiol 22: 368-372.
16. Wang R, Lam P, Liu L, Forrest D, Yousef IM, Mignault D, Phillips MJ, Ling V (2003) Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein. Hepatology 38: 1489-1499.