Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats

Biomedical Chromatography

Volumn 26, Issue 10, 2012, Pages 1234-1240

  Li, Yueyue ^a   Zhao, Liang ^a   Zhang, Hai ^a   Jia, Jing ^a   Lv, Lei ^a   Zhou, Guichen ^a   Chai, Yifeng ^a   Zhang, Guoqing ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cimifugin; Liquid chromatography mass spectrometry; Pharmacokinetics; Prim O glucosylcimifugin; Radix Saposhnikoviae

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; FLAVONOIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOMERS; PRECIPITATION (CHEMICAL); RATS;

CIMIFUGIN; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MONOMER SOLUTIONS; ORAL ADMINISTRATION; PLASMA SAMPLES; PRIM-O-GLUCOSYLCIMIFUGIN; PROTEIN PRECIPITATION; RADIX SAPOSHNIKOVIAE; RAT PLASMA; SIMULTANEOUS DETERMINATIONS;

PHARMACOKINETICS;

ACETONITRILE; CIMIFUGIN; DAIDZEIN; FORMIC ACID; METHANOL; MONOMER; PLANT EXTRACT; PRIM O GLUCOSYLCIMIFUGIN; PUERARIN; SAPOSHNIKOVIAE EXTRACT; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG METABOLISM; ELECTROSPRAY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; NONHUMAN; PLANT ROOT; PRECIPITATION; RAT; RELIABILITY; SAPOSHNIKOVIAE;

RATTUS;

EID: 84865750405     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2684     Document Type: Article

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