A multifactorial relationship exists between total circulating cell-free DNA levels and maternal BMI

Prenatal Diagnosis

Volumn 32, Issue 9, 2012, Pages 912-914

  Vora, Neeta L ^a   Johnson, Kirby L ^a   Basu, Subhabrata ^b   Catalano, Patrick M ^b   Hauguel De Mouzon, Sylvie ^b   Bianchi, Diana W ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL FREE DNA; DNA; GLYCERALDEHYDE 3 PHOSPHATE; UNCLASSIFIED DRUG;

ADIPOCYTE; BODY MASS; BODY WEIGHT; CELL DEATH; CHILD WELFARE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; FEMALE; FETUS; GESTATIONAL AGE; HUMAN; HYDRATION; LABOR; LETTER; MALE; MATERNAL BLOOD; MATERNAL OBESITY; MATERNAL WELFARE; PARITY; PREGNANT WOMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SECOND TRIMESTER PREGNANCY; Y CHROMOSOME;

BODY MASS INDEX; CASE-CONTROL STUDIES; CAUSALITY; DNA; DOWN SYNDROME; FEMALE; GENETIC TESTING; HUMANS; MOTHERS; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL DIAGNOSIS; REFERENCE VALUES; THINNESS;

EID: 84865724542     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.3919     Document Type: Letter

References (9)

1. Kim SY, Dietz PM, England L, Morrow B, Callaghan WM. Trends in prepregnancy obesity in nine states, 1993-2003. Obesity 2007;15:986-93.
2. Lapaire O, Volgmann T, Grill S, et al. Significant correlation between maternal body mass index at delivery and in the second trimester, and second trimester circulating total cell-free DNA levels. Reprod Sci 2009;16:274-9.
3. Haghiac M, Vora NL, Basu S, et al. Increased death of adipose cells, a path to release cell-free DNA into systemic circulation of obese women. Obesity 2012; in press.
4. Johnson KL, Dukes KA, Vidaver J, et al. Inter-laboratory comparison of fetal male DNA detection from common maternal plasma samples by real-time PCR. Clin Chem 2004;50:516-21.
5. Lo YM, Tein MS, Lau TK, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 1998;62:768-75.
6. Lemmens HJ, Bernstein DP, Brodsky JB. Estimating blood volume in obese and morbidly obese patients. Obes Surg 2006;16:773-6.
7. Watanagara T, Peter I, Messerlian GM, et al. Inverse correlation between maternal weight and second trimester circulating cell-free fetal DNA levels. Obstet Gynecol 2004;104:545-50.
8. Neveux LM, Palomaki GE, Larrivee DA, et al. Refinements in managing maternal weight adjustment for interpreting prenatal screening results. Prenat Diagn 1996;16:1115-9.
9. Palomaki GE, Kloza EM, Lambert-Messerlian GM, et al. DNA sequencing of maternal plasma to detect Down syndrome: an international clinical validation study. Genet Med 2011;13:913-20.