Mechanism of action of therapeutic monoclonal antibodies: Promises and pitfalls of in vitro and in vivo assays

Archives of Biochemistry and Biophysics

Volumn 526, Issue 2, 2012, Pages 146-153

  Golay, Josée ^a   Introna, Martino ^a  

^a OSPEDALI RIUNITI   (Italy)

Author keywords

ADCC; Antibody; Cell death; Complement; Phagocytosis

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALEMTUZUMAB; BRENTUXIMAB VEDOTIN; CALCEIN; CALICHEAMICIN; CD16 ANTIGEN; CD20 ANTIBODY; CETUXIMAB; CHROMIUM 51; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C9; DACLIZUMAB; DUOCARMYCIN DERIVATIVE; GEMTUZUMAB OZOGAMICIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MAYTANSINE; MONOCLONAL ANTIBODY; PROPIDIUM IODIDE; RITUXIMAB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; TRYPAN BLUE; VEDOTIN;

ANTIBODY SCREENING; APOPTOSIS; BIOASSAY; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; COLORECTAL CARCINOMA; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; DISEASE MODEL; DNA FRAGMENTATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG INDUSTRY; DRUG MECHANISM; DRUG SCREENING; EFFECTOR CELL; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPE; GRAFT REJECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LUNG SMALL CELL CANCER; MONOCYTE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NICK END LABELING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; SCID MOUSE; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; CELL DEATH; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNE SYSTEM; IMMUNOCONJUGATES; IMMUNOGLOBULIN FRAGMENTS; PHAGOCYTOSIS;

ANIMALIA;

EID: 84865699475     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2012.02.011     Document Type: Review

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