Ultrasonic measurement of scleral cross-sectional strains during elevations of intraocular pressure: Method validation and initial results in posterior porcine sclera

Journal of Biomechanical Engineering

Volumn 134, Issue 9, 2012, Pages

  Tang, Junhua ^a   Liu, Jun ^a  

^a Ohio State University   (United States)

Author keywords

porcine sclera; scleral mechanics; strain imaging; ultrasound speckle tracking

Indexed keywords

ANALYSIS AND SIMULATION; AXIAL STRAIN; BIOMECHANICAL PROPERTIES; CIRCUMFERENTIAL DIRECTION; DISPLACEMENT FIELD; EXPERIMENTAL VALIDATIONS; HIGH FREQUENCY HF; HIGH SNR; INTRA OCULAR PRESSURE; KERNEL SIZE; LATERAL DIRECTIONS; LATERAL STRAIN; LEAST SQUARES; METHOD VALIDATIONS; NEW EXPERIMENTAL METHOD; PORCINE SCLERA; PRESSURE INCREASE; PROCESSING PARAMETERS; RADIO-FREQUENCY DATUM; SIGNALTONOISE RATIO (SNR); STRAIN ESTIMATION; STRAIN IMAGING; STRAIN LEVELS; STRAIN MAGNITUDE; STRAIN MAPS; SUBMICRON; TISSUE DISPLACEMENT; TORONTO; ULTRASOUND METHODS; ULTRASOUND SPECKLE; ULTRASOUND SYSTEM;

BIOMECHANICS; ESTIMATION; SIGNAL PROCESSING; SOFTWARE PACKAGES; SPECKLE; TISSUE; ULTRASONICS;

STRAIN;

ACCURACY; ANIMAL TISSUE; ARTICLE; EXPERIMENTAL PIG; INTRAOCULAR PRESSURE; NONHUMAN; PATHOGENESIS; RADIOFREQUENCY; SCLERA; SIGNAL NOISE RATIO; SIGNAL PROCESSING; SIMULATION; ULTRASOUND; VALIDATION PROCESS; ANIMAL; BIOMECHANICS; ECHOGRAPHY; EQUIPMENT; MECHANICAL STRESS; METHODOLOGY; PHYSIOLOGY; REPRODUCIBILITY; SWINE;

SUS;

ANIMALS; BIOMECHANICS; INTRAOCULAR PRESSURE; REPRODUCIBILITY OF RESULTS; SCLERA; SIGNAL-TO-NOISE RATIO; STRESS, MECHANICAL; SWINE; ULTRASONICS;

EID: 84865693410     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4007365     Document Type: Article

References (57)

1. Kingman, S., 2004, "Glaucoma is Second Leading Cause of Blindness Globally," Bull. World Health Organ., 82(11), pp. 887-888. Available at http://www.scielosp.org/pdf/bwho/v82n11/v82n11a19.pdf
2. Burgoyne, C. F., Downs, J. C., Bellezza, A. J., Suh, J. K. F., and Hart, R. T., 2005, "The Optic Nerve Head as a Biomechanical Structure: A New Paradigm for Understanding the Role of IOP-Related Stress and Strain in the Pathophysiology of Glaucomatous Optic Nerve Head Damage," Prog. Retin. Eye Res., 24(1), pp. 39-73. (Pubitemid 39535155)
3. Sigal, I. A., Flanagan, J. G., and Ethier, C. R., 2005, "Factors Influencing Optic Nerve Head Biomechanics," Invest. Ophthalmol. Visual Sci., 46(11), pp. 4189-4199. (Pubitemid 44264622)
4. Sigal, I. A., Flanagan, J. G., Tertinegg, I., and Ethier, C. R., 2009, "Modeling Individual-Specific Human Optic Nerve Head Biomechanics. Part II: Influence of Material Properties," Biomech. Model. Mechanobiol., 8(2), pp. 99-109.
5. McBrien, N. A., Cornell, L. M., and Gentle, A., 2001, "Structural and Ultrastructural Changes to the Sclera in a Mammalian Model of High Myopia," Invest. Ophthalmol. Visual Sci., 42(10), pp. 2179-2187. Available at http://www.ncbi.nlm.nih.gov/pubmed/11527928 (Pubitemid 32848844)
6. Phillips, J. R., and Mcbrien, N. A., 1995, "Form Deprivation Myopia-Elastic Properties of Sclera," Ophthalmic Physiol. Opt., 15(5), pp. 357-362.
7. Siegwart, J. T., and Norton, T. T., 1999, "Regulation of the Mechanical Properties of Tree Shrew Sclera by the Visual Environment," Vision Res., 39(2), pp. 387-407. (Pubitemid 29052382)
8. McBrien, N. A., Jobling, A. I., and Gentle, A., 2009, "Biomechanics of the Sclera in Myopia: Extracellular and Cellular Factors," Optom. Vision Sci., 86(1), pp. 23-30.
9. Mitchell, P., Hourihan, F., Sandbach, J., and Wang, J. J., 1999, "The Relationship Between Glaucoma and Myopia-The Blue Mountains Eye Study," Ophthalmology, 106(10), pp. 2010-2015.
10. Watson, P. G., and Young, R. D., 2004, "Scleral Structure, Organisation and Disease. A Review," Exp. Eye Res., 78(3), pp. 609-623. (Pubitemid 38183340)
11. Friberg, T. R., and Lace, J. W., 1988, "A Comparison of the Elastic Properties of Human Choroid and Sclera," Exp. Eye Res., 47(3), pp. 429-436.
12. Elsheikh, A., Geraghty, B., Alhasso, D., Knappett, J., Campanelli, M., and Rama, P., 2010, "Regional Variation in the Biomechanical Properties of the Human Sclera," Exp. Eye Res., 90(5), pp. 624-633.
13. Downs, J. C., Suh, J. K. F., Thomas, K. A., Bellezza, A. J., Hart, R. T., and Burgoyne, C. F., 2005, "Viscoelastic Material Properties of the Peripapillary Sclera in Normal and Early-Glaucoma Monkey Eyes," Invest. Ophthalmol. Visual Sci., 46(2), pp. 540-546. (Pubitemid 40270333)
14. Schultz, D. S., Lotz, J. C., Lee, S. M., Trinidad, M. L., and Stewart, J. M., 2008, "Structural Factors That Mediate Scleral Stiffness," Invest. Ophthalmol. Visual Sci., 49(10), pp. 4232-4236.
15. Palko, J. R., Pan, X. L., and Liu, J., 2011, "Dynamic Testing of Regional Viscoelastic Behavior of Canine Sclera," Exp. Eye Res., 93(6), pp. 825-832.
16. Curtin, B. J., 1969, "Physiopathologic Aspects of Scleral Stress-Strain," Trans. Am. Ophthalmol. Soc., 67, pp. 417-461.
17. Eilaghi, A., Flanagan, J. G., Tertinegg, I., Simmons, C. A., Brodland, G. W., and Ethier, C. R., 2010, "Biaxial Mechanical Testing of Human Sclera," J. Biomechanics, 43(9), pp. 1696-1701.
18. Mortazavi, A. M., Simon, B. R., Stamer, W. D., and Geest, J. P. V., 2009, "Drained Secant Modulus for Human and Porcine Peripapillary Sclera Using Unconfined Compression Testing," Exp. Eye Res., 89(6), pp. 892-897.
19. Battaglioli, J. L., and Kamm, R. D., 1984, "Measurements of the Compressive Properties of Scleral Tissue," Invest. Ophthalmol. Visual Sci., 25(1), pp. 59-65. (Pubitemid 14220988)
20. Woo, S. L-Y., Kobayashi, A. S., Schlegela, W. A., and Lawrence, C., 1972, "Nonlinear Material Properties of Intact Cornea and Sclera," Exp. Eye Res., 14(1), pp. 29-39.
21. Girard, M. J. A., Downs, J. C., Burgoyne, C. F., and Suh, J. K. F., 2008, "Experimental Surface Strain Mapping of Porcine Peripapillary Sclera due to Elevations of Intraocular Pressure," ASME J. Biomech. Eng., 130(4), p. 041017.
22. Myers, K. M., Cone, F. E., Quigley, H. A., Gelman, S., Pease, M. E., and Nguyen, T. D., 2010, "The In Vitro Inflation Response of Mouse Sclera," Exp. Eye Res., 91(6), pp. 866-875.
23. Myers, K. M., Coudrillier, B., Boyce, B. L., and Nguyen, T. D., 2010, "The Inflation Response of the Posterior Bovine Sclera," Acta Biomater., 6(11), pp. 4327-4335.
24. Greene, P. R., and Mcmahon, T. A., 1979, "Scleral Creep Vs Temperature and Pressure in vitro," Exp. Eye Res., 29(5), pp. 527-537. (Pubitemid 10185559)
25. Girard, M. J. A., Downs, J. C., Bottlang, M., Burgoyne, C. F., and Suh, J. K. F., 2009, "Peripapillary and Posterior Scleral Mechanics-Part II: Experimental and Inverse Finite Element Characterization," ASME J. Biomech. Eng., 131(5), p. 051011.
26. Girard, M. J. A., Downs, J. C., Burgoyne, C. F., and Suh, J. K. F., 2009, "Peripapillary and Posterior Scleral Mechanics-Part I: Development of an Anisotropic Hyperelastic Constitutive Model," ASME J. Biomech. Eng., 131(5), p. 051012.
27. Ophir, J., Cespedes, I., Ponnekanti, H., Yazdi, Y., and Li, X., 1991, "Elastography-A Quantitative Method for Imaging the Elasticity of Biological Tissues," Ultrason. Imaging, 13(2), pp. 111-134.
28. Odonnell, M. Skovoroda, A. R. Shapo, B. M. and Emelianov, S. Y., 1994, "Internal Displacement and Strain Imaging Using Ultrasonic Speckle Tracking," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 41(3), pp. 314-325.
29. Krouskop, T. A., Wheeler, T. M., Kallel, F., Garra, B. S., and Hall, T., 1998, "Elastic Moduli of Breast and Prostate Tissues under Compression," Ultrason. Imaging, 20(4), pp. 260-274. Available at http://www.ncbi.nlm.nih.gov/pubmed/10197347 (Pubitemid 29168827)
30. Suffoletto, M. S., Dohi, K., Cannesson, M., Saba, S., and Gorcsan, J., 2006, "Novel Speckle-Tracking Radial Strain From Routine Black-and-White Echocardiographic Images to Quantify Dyssynchrony and Predict Response to Cardiac Resynchronization Therapy," Circulation, 113(7), pp. 960-968. (Pubitemid 43879471)
31. Ryan, L. K., and Foster, F. S., 1997, "Ultrasonic Measurement of Differential Displacement Strain in a Vascular Model," Ultrason. Imaging, 19(1), pp. 19-38. (Pubitemid 27371507)
32. Righetti, R., Kallel, F., Stafford, R. J., Price, R. E., Krouskop, T. A., Hazle, J. D., and Ophir, J., 1999, "Elastographic Characterization of HIFU-Induced Lesions in Canine Livers," Ultrasound in Med. Biol., 25(7), pp. 1099-1113. (Pubitemid 29408504)
33. Kallel, F., Ophir, J., Magee, K., and Krouskop, T., 1998, "Elastographic Imaging of Low-Contrast Elastic Modulus Distributions in Tissue," Ultrasound Med. Biol., 24(3), pp. 409-425. (Pubitemid 28164833)
34. Kallel, F., Price, R. E., Konofagou, E., and Ophir, J., 1999, "Elastographic Imaging of the Normal Canine Prostate In Vitro," Ultrason. Imaging, 21(3), pp. 201-215. (Pubitemid 30005050)
35. Bohs, L. N., and Trahey, G. E., 1991, "A Novel Method for Angle Independent Ultrasonic-Imaging of Blood-Flow and Tissue Motion," IEEE Trans. Biomed. Eng., 38(3), pp. 280-286.
36. Angelini, E. D., and Gerard, O., 2006, "Review of Myocardial Motion Estimation Methods From Optical Flow Tracking on Ultrasound Data," 2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols. 1-15, pp. 6337-6340.
37. Kallel, F., and Ophir, J., 1997, "A Least-Squares Strain Estimator for Elastography," Ultrason. Imaging, 19(3), pp. 195-208. Available at http://www.ncbi.nlm.nih.gov/pubmed/9447668 (Pubitemid 28036069)
38. Nightingale, K. R., Palmeri, M. L., Nightingale, R. W., and Trahey, G. E., 2001, "On the Feasibility of Remote Palpation Using Acoustic Radiation Force," J. Acoust. Soc. Am., 110(1), pp. 625-634. (Pubitemid 32642598)
39. Konofagou, E. E., and Hynynen, K., 2003, "Localized Harmonic Motion Imaging: Theory, Simulations and Experiments," Ultrasound Med. Biol., 29(10), pp. 1405-1413. (Pubitemid 37338750)
40. Srinivasan, S., Righetti, R., and Ophir, J., 2003, "Trade-offs Between the Axial Resolution and the Signal-to-Noise Ratio in Elastography," Ultrasound Med. Biol., 29(6), pp. 847-866. (Pubitemid 36808637)
41. Varghese, T., and Ophir, J., 1997, "A Theoretical Framework for Performance Characterization of Elastography: The Strain Filter," IEEE Trans. Ultrason.Ferroelectr. Freq. Control, 44(1), pp. 164-172. (Pubitemid 127771201)
42. Skovoroda, A. R., Emelianov, S. Y., Lubinski, M. A., Sarvazyan, A. P., and Odonnell, M., 1994, "Theoretical-Analysis and Verification of Ultrasound Displacement and Strain Imaging," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 41(3), pp. 302-313.
43. Varghese, T., Bilgen, M., and Ophir, J., 1998, "Multiresolution Imaging in Elastography," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 45(1), pp. 65-75. (Pubitemid 128748667)
44. Varghese, T., Ophir, J., Konofagou, E., Kallel, F., and Righetti, R., 2001, "Tradeoffs in Elastographic Imaging," Ultrason. Imaging, 23(4), pp. 216-248. Available at http://www.ncbi.nlm.nih.gov/pubmed/12051276 (Pubitemid 34568615)
45. Hollman, K. W., Emelianov, S. Y., Neiss, J. H., Jotyan, G., Spooner, G. J. R., Juhasz, T., Kurtz, R. M., and O'Donnell, M., 2002, "Strain Imaging of Corneal Tissue with an Ultrasound Elasticity Microscope," Cornea, 21(1), pp. 68-73. (Pubitemid 33144407)
46. Ford, M. R., Dupps, W. J., Rollins, A. M., Roy, A. S., and Hu, Z. L., 2011, "Method for Optical Coherence Elastography of the Cornea," J. Biomed. Optics, 16(1), p. 016005.
47. Cohn, N. A., Emelianov, S. Y., Lubinski, M. A., and ODonnell, M., 1997, "An Elasticity Microscope. 1. Methods," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 44(6), pp. 1304-1319.
48. Weinstein, E., and Weiss, A. J., 1984, "Fundamental Limitations in Passive Time-Delay Estimation. 2. Wideband Systems," IEEE Trans. Acoust., Speech, Signal Process., 32(5), pp. 1064-1078. (Pubitemid 14673643)
49. Jensen, J. A., 1996, "Field: A Program for Simulating Ultrasound Systems," 10th Nordicbaltic Conference on Biomedical Imaging, Vol. 4(1), pp. 351-353.
50. Jensen, J. A., and Svendsen, N. B., 1992, "Calculation of Pressure Fields from Arbitrarily Shaped, Apodized, and Excited Ultrasound Transducers," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 39(2), pp. 262-267.
51. Zagzebski, J. A., Chen, J. F., Dong, F., and Wilson, T., 1999, "Intervening Attenuation Affects First-Order Statistical Properties of Ultrasound Echo Signals," IEEE Trans. Ultrason. Ferroelectr. Freq. Control, 46(1), pp. 35-40.
52. Komai, Y., and Ushiki, T., 1991, "The 3-Dimensional Organization of Collagen Fibrils in the Human Cornea and Sclera," Invest. Ophthalmol. Visual Sci., 32(8), pp. 2244-2258.
53. Haider, M. A., and Guilak, F., 2007, "Application of a Three-Dimensional Poroelastic BEM to Modeling the Biphasic Mechanics of Cell-Matrix Interactions in Articular Cartilage," Comput. Methods Applied Mech. Eng., 196(31-32), pp. 2999-3010. (Pubitemid 46712210)
54. Ma, J., Narayanan, H., Garikipati, K., Grosh, K., and Arruda, E. M., 2010, "Experimental and Computational Investigation of Viscoelasticity of Native and Engineered Ligament and Tendon," Proc. IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, Vol. 16, pp. 3-17.
55. Greene, P. R., 1980, "Mechanical Considerations in Myopia-Relative Effects of Accommodation, Convergence, Intraocular-Pressure, and the Extra-Ocular Muscles," Am. J. Optom. Physiol. Opt., 57(12), pp. 902-914. (Pubitemid 11169364)
56. Chen, X. C., Zohdy, M. J., Emelianov, S. Y., and O'Donnell, M., 2004, "Lateral Speckle Tracking Using Synthetic Lateral Phase," IEEEeee Trans. Ultrason. Ferroelectr. Freq. Control, 51(5), pp. 540-550.
57. Huang, Y., and Meek, K. M., 1999, "Swelling Studies on the Cornea and Sclera: The Effects of pH and Ionic Strength," Biophys. J., 77(3), pp. 1655-1665.