An embryo cleavage pattern based on the relative blastomere size as a function of cell number for predicting implantation outcome

Fertility and Sterility

Volumn 98, Issue 3, 2012, Pages

  Sela, Roee ^a   Samuelov, Liat ^a   Almog, Benny ^a   Schwartz, Tamar ^a   Cohen, Tania ^a   Amit, Ami ^a   Azem, Foad ^a   Ben Yosef, Dalit ^a,b  

^a LIS MATERNITY HOSPITAL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Blastomere uniformity; cleavage pattern; cleavage rate; embryo score; symmetry

Indexed keywords

ARTICLE; BLASTOMERE; CELL COUNT; CELL DIVISION; CELL FUNCTION; CELL SIZE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; INFERTILITY; NIDATION; OUTCOME ASSESSMENT; PREDICTION; PREGNANCY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT FAILURE;

EID: 84865682383     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2012.05.041     Document Type: Article

References (30)

1. S. Alfarawati, E. Fragouli, P. Colls, J. Stevens, C. Gutierrez-Mateo, and W.B. Schoolcraft The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender Fertil Steril 95 2011 520 524
2. M. Meseguer, J. Herrero, A. Tejera, K.M. Hilligsoe, N.B. Ramsing, and J. Remohi The use of morphokinetics as a predictor of embryo implantation Hum Reprod 26 2011 2658 2671
3. L. Nel-Themaat, and Z.P. Nagy A review of the promises and pitfalls of oocyte and embryo metabolomics Placenta 32 Suppl 3 2011 S257 S263
4. G. De Placido, M. Wilding, I. Strina, E. Alviggi, C. Alviggi, and A. Mollo High outcome predictability after IVF using a combined score for zygote and embryo morphology and growth rate Hum Reprod 17 2002 2402 2409
5. E. Van Royen, K. Mangelschots, D. De Neubourg, I. Laureys, G. Ryckaert, and J. Gerris Calculating the implantation potential of day 3 embryos in women younger than 38 years of age: a new model Hum Reprod 16 2001 326 332
6. C. Hnida, E. Engenheiro, and S. Ziebe Computer-controlled, multilevel, morphometric analysis of blastomere size as biomarker of fragmentation and multinuclearity in human embryos Hum Reprod 19 2004 288 293
7. T. della Ragione, G. Verheyen, E.G. Papanikolaou, L. Van Landuyt, P. Devroey, and A. Van Steirteghem Developmental stage on day-5 and fragmentation rate on day-3 can influence the implantation potential of top-quality blastocysts in IVF cycles with single embryo transfer Reprod Biol Endocrinol 5 2007 2
8. C. Giorgetti, P. Terriou, P. Auquier, E. Hans, J.L. Spach, and J. Salzmann Embryo score to predict implantation after in-vitro fertilization: based on 957 single embryo transfers Hum Reprod 10 1995 2427 2431
9. S. Ziebe, K. Petersen, S. Lindenberg, A.G. Andersen, A. Gabrielsen, and A.N. Andersen Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization Hum Reprod 12 1997 1545 1549
10. C. Hnida, I. Agerholm, and S. Ziebe Traditional detection versus computer-controlled multilevel analysis of nuclear structures from donated human embryos Hum Reprod 20 2005 665 671
11. K. Lundin, C. Bergh, and T. Hardarson Early embryo cleavage is a strong indicator of embryo quality in human IVF Hum Reprod 16 2001 2652 2657
12. L. Rienzi, F. Ubaldi, M. Iacobelli, S. Romano, M.G. Minasi, and S. Ferrero Significance of morphological attributes of the early embryo Reprod Biomed Online 10 2005 669 681
13. L. Scott, A. Finn, T. O'Leary, S. McLellan, and J. Hill Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates Hum Reprod 22 2007 230 240
14. J. Tesarik, A.M. Junca, A. Hazout, F.X. Aubriot, C. Nathan, and P. Cohen-Bacrie Embryos with high implantation potential after intracytoplasmic sperm injection can be recognized by a simple, non-invasive examination of pronuclear morphology Hum Reprod 15 2000 1396 1399
15. Y. Shoukir, A. Campana, T. Farley, and D. Sakkas Early cleavage of in-vitro fertilized human embryos to the 2-cell stage: a novel indicator of embryo quality and viability Hum Reprod 12 1997 1531 1536
16. C. Sifer, N. Sermondade, C. Poncelet, E. Hafhouf, R. Porcher, and I. Cedrin-Durnerin Biological predictive criteria for clinical pregnancy after elective single embryo transfer Fertil Steril 95 2011 427 430
17. J. Holte, L. Berglund, K. Milton, C. Garello, G. Gennarelli, and A. Revelli Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval Hum Reprod 22 2007 548 557
18. S.J. Dennis, M.A. Thomas, D.B. Williams, and J.C. Robins Embryo morphology score on day 3 is predictive of implantation and live birth rates J Assist Reprod Genet 23 2006 171 175
19. L. Scott, R. Alvero, M. Leondires, and B. Miller The morphology of human pronuclear embryos is positively related to blastocyst development and implantation Hum Reprod 15 2000 2394 2403
20. M. Nomura, A. Iwase, K. Furui, T. Kitagawa, Y. Matsui, and M. Yoshikawa Preferable correlation to blastocyst development and pregnancy rates with a new embryo grading system specific for day 3 embryos J Assist Reprod Genet 24 2007 23 28
21. T. Hardarson, C. Hanson, A. Sjogren, and K. Lundin Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation Hum Reprod 16 2001 313 318
22. P. Terriou, C. Sapin, C. Giorgetti, E. Hans, J.L. Spach, and R. Roulier Embryo score is a better predictor of pregnancy than the number of transferred embryos or female age Fertil Steril 75 2001 525 531
23. P. Saldeen, and P. Sundstrom Nuclear status of four-cell preembryos predicts implantation potential in in vitro fertilization treatment cycles Fertil Steril 84 2005 584 589
24. C. Simon, C. Moreno, J. Remohi, and A. Pellicer Cytokines and embryo implantation J Reprod Immunol 39 1998 117 131
25. T. Frumkin, M. Malcov, Y. Yaron, and D. Ben-Yosef Elucidating the origin of chromosomal aberrations in IVF embryos by preimplantation genetic analysis Mol Cell Endocrinol 282 2008 112 119
26. M.C. Magli, L. Gianaroli, A.P. Ferraretti, M. Lappi, A. Ruberti, and V. Farfalli Embryo morphology and development are dependent on the chromosomal complement Fertil Steril 87 2007 534 541
27. S. Ziebe, K. Lundin, A. Loft, C. Bergh, A. Nyboe Andersen, and U. Selleskog FISH analysis for chromosomes 13, 16, 18, 21, 22, X and Y in all blastomeres of IVF pre-embryos from 144 randomly selected donated human oocytes and impact on pre-embryo morphology Hum Reprod 18 2003 2575 2581
28. F. Guerif, A. Le Gouge, B. Giraudeau, J. Poindron, R. Bidault, and O. Gasnier Limited value of morphological assessment at days 1 and 2 to predict blastocyst development potential: a prospective study based on 4042 embryos Hum Reprod 22 2007 1973 1981
29. M.C. Magli, L. Gianaroli, and A.P. Ferraretti Chromosomal abnormalities in embryos Mol Cell Endocrinol 183 Suppl 1 2001 S29 S34
30. J.G. Lemmen, I. Agerholm, and S. Ziebe Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes Reprod Biomed Online 17 2008 385 391