Brain, physiological and behavioral modulation induced by immune stimulation in honeybees (Apis mellifera): A potential mediator of social immunity?

Brain, Behavior, and Immunity

Volumn 26, Issue 7, 2012, Pages 1057-1060

  Alaux, Cédric ^a   Kemper, Nele ^a   Kretzschmar, André ^b   Le Conte, Yves ^a  

^a Laboratoire de Toxicologie Environnementale   (France)

^b INRA   (France)

Author keywords

Brain gene expression; Honeybees; Lipopolysaccharides; Queen attendance; Social immunity

Indexed keywords

LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; BROOD PARASITE; FORAGER; FORAGING; GENE EXPRESSION; HONEYBEE; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; QUEEN (INSECT); SOCIAL BEHAVIOR;

AGING; ANIMALS; BEES; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DROSOPHILA PROTEINS; EXOCRINE GLANDS; GENE EXPRESSION; HEMOLYMPH; IMMUNITY; ION PUMPS; LIPOPOLYSACCHARIDES; PHEROMONES; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT;

EID: 84865654921     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.04.004     Document Type: Article

References (29)

1. Amdam G.V., Page R.E. The developmental genetics and physiology of honeybee societies. Anim. Behav. 2010, 79:973-980.
2. Amdam G.V., Simões Z.L.P., Hagen A., Norberg K., Schrøder K., Mikkelsen Ø., Kirkwood T.B.L., Omholt S.W. Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees. Exp. Gerontol. 2004, 39:767-773.
3. Aubert A., Renault J. Cytokines and immune-related behaviors. NeuroImmune Biology 2008, 529-547. Elsevier Science. C. Phelps, K. Korneva (Eds.).
4. Aubert A., Richard F.J. Social management of LPS-induced inflammation in Formica polyctena ants. Brain Behav. Immun. 2008, 22:833-837.
5. Ben-Shahar Y., Dudek N.L., Robinson G.E. Phenotypic deconstruction reveals involvement of manganese transporter malvolio in honey bee division of labor. J. Exp. Biol. 2004, 207:3281-3288.
6. Ben-Shahar Y., Robichon A., Sokolowski M.B., Robinson G.E. Influence of gene action across different time scales on behavior. Science 2002, 296:741-744.
7. Bos N., Lefevre T., Jensen A.B., D'Ettorre P. Sick ants become unsociable. J. Evol. Biol. 2012, 25:342-351.
8. Crailsheim K., Stolberg E. Influence of diet, age and colony condition upon intestinal proteolytic activity and size of the hypopharyngeal glands in the honeybee (Apis mellifera L). J. Insect Physiol. 1989, 35:595-602.
9. Cremer S., Armitage S.A., Schmid-Hempel P. Social immunity. Curr. Biol. 2007, 17:R693-702.
10. Dantzer R. Innate immunity at the forefront of psychoneuroimmunology. Brain Behav. Immun. 2004, 18:1-6.
11. Deseyn J., Billen J. Age-dependent morphology and ultrastructure of the hypopharyngeal gland of Apis mellifera workers (Hymenoptera, Apidae). Apidologie 2005, 36:49-57.
12. Flatt T., Heyland A., Rus F., Porpiglia E., Sherlock C., Yamamoto R., Garbuzov A., Palli S.R., Tatar M., Silverman N. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J. Exp. Biol. 2008, 211:2712-2724.
13. Gillespie J.P., Kanost M.R., Trenczek T. Biological mediators of insect immunity. Annu. Rev. Entomol. 1997, 42:611-643.
14. Hart B.L. Behavioral adaptations to pathogens and parasites - 5 strategies. Neurosci. Biobehav. Rev. 1990, 14:273-294.
15. Heinze J., Walter B. Moribund ants leave their nests to die in social isolation. Curr. Biol. 2010, 20:249-252.
16. Hoffmann J.A. The immune response of Drosophila. Nature 2003, 426:33-38.
17. Korner P., Schmid-Hempel P. In vivo dynamics of an immune response in the bumble bee Bombus terrestris. J. Invertebr. Pathol. 2004, 87:59-66.
18. Mallon E.B., Brockmann A., Schmid-Hempel P. Immune function inhibits memory formation in the honeybee Apis mellifera. Proc. R. Soc. B 2003, 270:2471-2473.
19. mlogit package 0.2-2, R Data Analysis Examples. UCLA, Academic Technology Services, Statistical Consulting Group. http://www.ats.ucla.edu/stat/r/dae/.
20. Moret Y., Schmid-Hempel P. Survival for immunity: the price of immune system activation for bumblebee workers. Science 2000, 290:1166-1168.
21. Richard F.-J., Aubert A., Grozinger C.M. Modulation of social interactions by immune stimulation in honey bee, Apis mellifera, workers. BMC Biol. 2008, 6:50.
22. Riddell C.E., Mallon E.B. Insect psychoneuroimmunology: immune response reduces learning in protein starved bumblebees (Bombus terrestris). Brain Behav. Immun. 2006, 20:135-138.
23. Rueppell O., Hayworth M.K., Ross N.P. Altruistic self-removal of health-compromised honey bee workers from their hive. J. Evol. Biol. 2010, 23:1538-1546.
24. Salvy M., Martin C., Bagneres A.G., Provost E., Roux M., Le Conte Y., Clement J.L. Modifications of the cuticular hydrocarbon profile of Apis mellifera worker bees in the presence of the ectoparasitic mite Varroa jacobsoni in brood cells. Parasitology 2001, 122:145-159.
25. Schmid-Hempel P. Parasites in Social Insects 1998, Princeton University Press, Princeton, NJ.
26. Seehuus S.C., Norberg K., Gimsa U., Krekling T., Amdam G.V. Reproductive protein protects functionally sterile honey bee workers from oxidative stress. Proc. Natl. Acad. Sci. USA 2006, 103:962-967.
27. Tian L., Guo E., Diao Y., Zhou S., Peng Q., Cao Y., Ling E., Li S. Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body. BMC Genomics 2010, 11:549.
28. Wang D.I., Moeller F.E. The division of labor and queen attendance behavior of Nosema infected worker honeybees. J. Econ. Entomol. 1970, 63:1539-1541.
29. Woyciechowski M., Kozlowski J. Division of labor by division of risk according to worker life expectancy in the honey bee (Apis mellifera L.). Apidologie 1998, 29:191-205.