Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 2, 2012, Pages 71-78

  Sarazan, R Dustan ^a   Kroehle, John P ^a   Main, Bradley W ^a  

^a Data Sciences International (DSI)   (United States)

Author keywords

Aliasing; Contractility; DP dtmax; Frequency response; Left ventricular pressure; Nyquist; Sample rate

Indexed keywords

ARTICLE; ARTIFACT; BLOOD PRESSURE; DRUG INDUSTRY; DRUG SAFETY; ELECTROCARDIOGRAPHY; HEART AFTERLOAD; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART PRELOAD; HEART RATE; HUMAN; IN VIVO STUDY;

ANIMALS; ANIMALS, LABORATORY; DOGS; DRUG EVALUATION, PRECLINICAL; HEART RATE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; PHARMACEUTICAL PREPARATIONS; RATS; TIME FACTORS; TOXICITY TESTS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

ANIMALIA; CANIS FAMILIARIS; PRIMATES; RATTUS;

EID: 84865651871     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.05.009     Document Type: Article

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