Radiation Therapy Oncology Group Protocol 02-29: A phase II trial of neoadjuvant therapy with concurrent chemotherapy and full-dose radiation therapy followed by surgical resection and consolidative therapy for locally advanced non-small cell carcinoma of the lung

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 2, 2012, Pages 456-463

  Suntharalingam, Mohan ^a   Paulus, Rebecca ^b   Edelman, Martin J ^a   Krasna, Mark ^c   Burrows, Whitney ^a   Gore, Elizabeth ^d   Wilson, Lynn D ^e   Choy, Hak ^f  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b RADIATION THERAPY ONCOLOGY GROUP   (United States)

^c Cancer Center at St Joseph Medical Center   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CELL CARCINOMA; CHEMORADIATION; CONCURRENT CHEMORADIATION; CONCURRENT CHEMOTHERAPY; INDUCTION CHEMOTHERAPY; NEOADJUVANT THERAPY; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; OVERALL SURVIVAL RATES; PACLITAXEL; PHASE II; PROGRESSION FREE SURVIVAL; PULMONARY COMPLICATIONS; RADIATION THERAPY ONCOLOGY GROUPS; SURGICAL RESECTION;

BIOLOGICAL ORGANS; CHEMORADIOTHERAPY; CHEMOTHERAPY; ONCOLOGY; TOXICITY;

RADIOTHERAPY;

CARBOPLATIN; CIMETIDINE; DEXAMETHASONE; DIPHENHYDRAMINE; PACLITAXEL; RANITIDINE;

ADJUVANT THERAPY; ADULT; ADVANCED CANCER; AGED; AIR LEAK; ALLERGY; ARTICLE; ATELECTASIS; BONE MARROW DISEASE; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CHEMORADIOTHERAPY; CONSOLIDATION CHEMOTHERAPY; EAR DISEASE; ENDOCRINE DISEASE; FEMALE; FOLLOW UP; GASTROINTESTINAL HEMORRHAGE; HEART ARRHYTHMIA; HEART SUPRAVENTRICULAR ARRHYTHMIA; HUMAN; IMMUNOPATHOLOGY; INDUCTION CHEMOTHERAPY; INFECTION; LOBECTOMY; LUNG DISEASE; LUNG EDEMA; LUNG NON SMALL CELL CANCER; LUNG RESECTION; LYMPHATIC SYSTEM DISEASE; MAJOR CLINICAL STUDY; MALE; MEDIASTINAL NODAL CLEARANCE; MEDIASTINUM; METABOLIC DISORDER; MINIMAL RESIDUAL DISEASE; MORBIDITY; MULTIPLE CYCLE TREATMENT; MUSCULOSKELETAL DISEASE; NEUROLOGIC DISEASE; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PLEURA EFFUSION; PNEUMONIA; PNEUMOTHORAX; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DOSE; SEXUAL DYSFUNCTION; SKIN DISEASE; SURGICAL MORTALITY; THROMBOSIS; TREATMENT PLANNING; TUMOR VOLUME; UROGENITAL TRACT DISEASE;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOMA, NON-SMALL-CELL LUNG; CONSOLIDATION CHEMOTHERAPY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MEDIASTINUM; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PACLITAXEL; PNEUMONECTOMY; PREOPERATIVE CARE; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE;

EID: 84865637205     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.11.069     Document Type: Article

References (18)

1. F. Andre, D. Grunenwald, and J.P. Pignon Survival of patients with resected N2 non-small-cell lung cancer: evidence for a subclassification and implications J Clin Oncol 18 2000 2981 2989
2. N. Martini, B.J. Flehinger, and M.B. Zaman Results of resection in non-oat cell carcinoma of the lung with mediastinal lymph node metastases Ann Surg 198 1983 386 397
3. R.O. Dillman, S.L. Seagren, and K.J. Propert A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer N Engl J Med 323 1990 940 945
4. K. Furuse, M. Fukuoka, and M. Kawahara Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer J Clin Oncol 17 1999 2692 2699
5. C. Schaake-Koning, W. van den Bogaert, and O. Dalesio Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer N Engl J Med 326 1992 524 530
6. R. Komaki, C. Scott, and J.S. Lee Impact of adding concurrent chemotherapy to hyperfractionated radiotherapy for locally advanced non-small cell lung cancer (NSCLC): comparison of RTOG 83-11 and RTOG 91-06 Am J Clin Oncol 20 1997 435 440
7. W.T. Sause, C. Scott, and S. Taylor Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer J Natl Cancer Inst 87 1995 198 205
8. K.S. Albain, V.W. Rusch, and J.J. Crowley Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805 J Clin Oncol 13 1995 1880 1892
9. D.J. Sugarbaker, J. Herndon, and L.J. Kohman Results of cancer and leukemia group B protocol 8935. A multiinstitutional phase II trimodality trial for stage IIIA (N2) non-small-cell lung cancer. Cancer and Leukemia Group B Thoracic Surgery Group J Thorac Cardiovasc Surg 109 1995 473 483 discussion 483-485
10. R. Bueno, W.G. Richards, and S.J. Swanson Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival Ann Thorac Surg 70 2000 1826 1831
11. D. Farray, N. Mirkovic, and K.S. Albain Multimodality therapy for stage III non-small-cell lung cancer J Clin Oncol 23 2005 3257 3269
12. R. Simon Optimal two-stage designs for phase II clinical trials Control Clin Trials 10 1989 1 10
13. E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
14. J.R. Sonett, M.J. Krasna, and M. Suntharalingam Safe pulmonary resection after chemotherapy and high-dose thoracic radiation Ann Thorac Surg 68 1999 316 320
15. J.R. Sonett, M. Suntharalingam, and M.J. Edelman Pulmonary resection after curative intent radiotherapy (>59 Gy) and concurrent chemotherapy in non-small-cell lung cancer Ann Thorac Surg 78 2004 1200 1205 discussion 1206
16. M.J. Edelman, M. Suntharalingam, and W. Burrows Phase I/II trial of hyperfractionated radiation and chemotherapy followed by surgery in stage III lung cancer Ann Thorac Surg 86 2008 903 910
17. K.S. Albain, R.S. Swann, and V.W. Rusch Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial Lancet 374 2009 379 386
18. D.C. Betticher, S.F. Hsu Schmitz, and M. Totsch Mediastinal lymph node clearance after docetaxel-cisplatin neoadjuvant chemotherapy is prognostic of survival in patients with stage IIIA pN2 non-small-cell lung cancer: a multicenter phase II trial J Clin Oncol 21 2003 1752 1759