Progress in radiotherapy for pediatric sarcomas

Current Oncology Reports

Volumn 14, Issue 4, 2012, Pages 320-326

  McGovern, Susan L ^a   Mahajan, Anita ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

3DCRT; Bone sarcoma; Brachytherapy; Ewing's sarcoma; IMRT; Late effects; Non rhabdomyosarcoma soft tissue sarcoma; Osteosarcoma; Pediatric sarcoma; Protons; Radiation; Radiotherapy; Rhabdomyosarcoma; Soft tissue sarcoma

Indexed keywords

ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CHILDHOOD CANCER; DISEASE FREE SURVIVAL; DISTANT METASTASIS; EMBRYONAL RHABDOMYOSARCOMA; EWING SARCOMA; EXTERNAL BEAM RADIOTHERAPY; HEART DISEASE; HIGH RISK PATIENT; HUMAN; HYPOTHYROIDISM; INDUCTION CHEMOTHERAPY; INTENSITY MODULATED RADIATION THERAPY; INTERSTITIAL RADIATION; LIVER TOXICITY; LUNG METASTASIS; LUNG TOXICITY; NON RHABDOMYOSARCOMA SOFT TISSUE SARCOMA; OSTEOSARCOMA; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PROTON RADIATION; RADIATION DOSE FRACTIONATION; RHABDOMYOSARCOMA; RISK ASSESSMENT; SARCOMA; SOFT TISSUE SARCOMA; STEREOTACTIC BODY RADIATION THERAPY; TREATMENT FAILURE;

BONE NEOPLASMS; BRACHYTHERAPY; CHILD; HUMANS; OSTEOSARCOMA; RADIATION INJURIES; SARCOMA; SARCOMA, EWING; SOFT TISSUE NEOPLASMS;

EID: 84865628987     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-012-0235-y     Document Type: Article

References (37)

1. SEER pediatric monograph on soft tissue sarcomas. Available at http://seer.cancer.gov/publications/childhood/softtissue.pdf. Accessed February 2012.
2. SEER pediatric monograph on malignant bone tumors. Available at http://seer.cancer.gov/publications/childhood/bone.pdf. Accessed February 2012.
3. Meza JL, Anderson J, Pappo AS, Meyer WH, Children's Oncology Group. Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: The Children's Oncology Group. J Clin Oncol. 2006;24:3844-51. (Pubitemid 46630730)
4. •• Breneman J, Meza J, Donaldson SS, et al. Local control with reduced-dose radiotherapy for low-risk rhabdomyosarcoma: A report from the Children's Oncology Group D9602 Study. Int J Radiat Oncol Biol Phys. 2011. doi:10.1016/j.ijrobp.2011.06.2011. Non-randomized prospective trial which found that reduced radiation doses did not compromise local control in low-risk RMS patients, as long as cyclophosphamide was included in the systemic therapy regimen.
5. Million L, Anderson J, Breneman J, et al. Influence of noncompliance with radiation therapy protocol guidelines and operative bed recurrences for children with rhabdomyosarcoma and microscopic residual disease: A report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys. 2011;80:333-8.
6. Ferrari A, Miceli R, Rey A, et al. Non-metastatic unresected paediatric non-rhabdomyosarcoma soft tissue sarcomas: Results of a pooled analysis from United States and European groups. Eur J Cancer. 2011;47:724-31.
7. Indelicato DJ, Keole SR, Shahlaee AH, et al. Definitive radiotherapy for Ewing tumors of extremities and pelvis: Long-term disease control, limb function, and treatment toxicity. Int J Radiat Oncol Biol Phys. 2008;72:871-7.
8. Indelicato DJ, Keole SR, Shahlaee AH, et al. Spinal and paraspinal Ewing tumors. Int J Radiat Oncol Biol Phys. 2010;76:1463-71.
9. Paulussen M, Ahrens S, Craft AW, et al. Ewing's tumors with primary lung metastases: Survival analysis of 114 (European Intergroup) Cooperative Ewing's Sarcoma Studies patients. J Clin Oncol. 1998;16:3044-52. (Pubitemid 28417425)
10. Bölling T, Schuck A, Paulussen M, et al. Whole lung irradiation in patients with exclusively pulmonary metastases of Ewing tumors. Toxicity analysis and treatment results of the EICESS-92 trial. Strahlenther Onkol. 2008;184:193-7. (Pubitemid 351508131)
11. Ogawa Y, Takahashi T, Kobayashi T, et al. Immunocytochemical characteristics of human osteosarcoma cell line HS-Os-1: Possible implication in apoptotic resistance against irradiation. Int J Mol Med. 2004;14:397-403.
12. Ciernik IF, Niemierko A, Harmon DC, et al. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011;117:4522-30.
13. Guadagnolo BA, Zagars GK, Raymond AK, Benjamin RS, Sturgis EM. Osteosarcoma of the jaw/craniofacial region: Outcomes after multimodality treatment. Cancer. 2009;115:3262-70.
14. Mahajan A, Woo SY, Kornguth DG, et al. Multimodality treatment of osteosarcoma: Radiation in a high-risk cohort. Pediatr Blood Cancer. 2008;50:976-82. (Pubitemid 351500174)
15. PosthumaDeBoer J, Würdinger T, Graat HC, et al. WEE1 inhibition sensitizes osteosarcoma to radiotherapy. BMC Cancer. 2011;11:156.
16. Blattmann C, Oertel S, Ehemann V, et al. Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition. Int J Radiat Oncol Biol Phys. 2010;78:237-45.
17. Chiu HW, Lin W, Ho SY, Wang YJ. Synergistic effects of arsenic trioxide and radiation in osteosarcoma cells through the induction of both autophagy and apoptosis. Radiat Res. 2011;175:547-60.
18. Laskar S, Bahl G, Ann Muckaden M, et al. Interstitial brachytherapy for childhood soft tissue sarcoma. Pediatr Blood Cancer. 2007;49:649-55. (Pubitemid 350194429)
19. Blank LE, Koedooder K, Pieters BR, et al. The AMORE protocol for advanced-stage and recurrent nonorbital rhabdomyosarcoma in the head-and-neck region of children: A radiation oncology view. Int J Radiat Oncol Biol Phys. 2009;74:1555-62.
20. Blank LE, Koedooder K, van der Grient HN, et al. Brachytherapy as part of the multidisciplinary treatment of childhood rhabdomyosarcomas of the orbit. Int J Radiat Oncol Biol Phys. 2010;77:1463-9.
21. Strege RJ, Kovács G, Meyer JE, et al. Perioperative intensitymodulated brachytherapy for refractory orbital rhabdomyosarcomas in children. Strahlenther Onkol. 2009;185:789-98.
22. Stannard C, Maree G, Munro R, Lecuona K, Sauerwein W. Iodine-125 orbital brachytherapy with a prosthetic implant in situ. Strahlenther Onkol. 2011;187:322-7.
23. Lin C, Donaldson SS, Meza JL, et al. Effect of radiotherapy techniques (IMRT vs. 3D-CRT) on outcome in patients with intermediate-risk rhabdomyosarcoma enrolled in COG D9803 -a report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys. 2012;82(5):1764-70.
24. Sterzing F, Stoiber EM, Nill S, et al. Intensity modulated radiotherapy (IMRT) in the treatment of children and adolescents-a single institution's experience and a review of the literature. Radiat Oncol. 2009;4:37.
25. Mesbah L, Matute R, Usychkin S, et al. Helical tomotherapy in the treatment of pediatric malignancies: A preliminary report of feasibility and acute toxicity. Radiat Oncol. 2011;6:102.
26. Blattmann C, Oertel S, Schulz-Ertner D, et al. Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma. BMC Cancer. 2010;10:96.
27. • Cotter SE, Herrup DA, Friedmann A, et al. Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: Clinical outcomes and dosimetry compared to intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2011;81:1367-73. A dosimetric comparison of proton and IMRT plans for seven patients with bladder or prostate rhabdomyosarcoma which showed that proton radiation significantly decreased dose to normal structures.
28. Yock T, Schneider R, Friedmann A, et al. Proton radiotherapy for orbital rhabdomyosarcoma: Clinical outcome and a dosimetric comparison with photons. Int J Radiat Oncol Biol Phys. 2005;63:1161-8. (Pubitemid 41509195)
29. Kozak KR, Adams J, Krejcarek SJ, Tarbell NJ, Yock TI. A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys. 2009;74:179-86.
30. Moeller BJ, Chintagumpala M, Philip JJ, et al. Low early ototoxicity rates for pediatric medulloblastoma patients treated with proton radiotherapy. Radiat Oncol. 2011;6:58.
31. Fogliata A, Yartsev S, Nicolini G, et al. On the performances of Intensity Modulated Protons, RapidArc and Helical Tomotherapy for selected paediatric cases. Radiat Oncol. 2009;4:2.
32. Heinzelmann F, Thorwarth D, Lamprecht U, et al. Comparison of different adjuvant radiotherapy approaches in childhood bladder/ prostate rhabdomyosarcoma treated with conservative surgery. Strahlenther Onkol. 2011;187:715-21.
33. • Selo N, Bölling T, Ernst I, et al. Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data. Radiother Oncol. 2010;97:119-26. This study provides comprehensive and detailed analyses of dose-volume relationships to acute toxicity for pediatric patients treated with radiation in the modern era.
34. Bölling T, Geisenheiser A, Pape H, et al. Hypothyroidism after head-and-neck radiotherapy in children and adolescents: Preliminary results of the "Registry for the Evaluation of Side Effects After Radiotherapy in Childhood and Adolescence" (RiSK). Int J Radiat Oncol Biol Phys. 2011;81:e787-91.
35. Ginsberg JP, Goodman P, Leisenring W, et al. Long-term survivors of childhood Ewing sarcoma: Report from the childhood cancer survivor study. J Natl Cancer Inst. 2010;102:1272-83.
36. Kadan-Lottick NS, Zeltzer LK, Liu Q, et al. Neurocognitive functioning in adult survivors of childhood non-central nervous system cancers. J Natl Cancer Inst. 2010;102:881-93.
37. Friedman DL, Whitton J, Leisenring W, et al. Subsequent neoplasms in 5-year survivors of childhood cancer: The Childhood Cancer Survivor Study. J Natl Cancer Inst. 2010;102:1083-95.