Decline in prefrontal catecholamine synthesis explains age-related changes in cognitive speed beyond regional grey matter atrophy

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 9, 2012, Pages 1462-1466

  Kalbitzer, Jan ^a   Deserno, Lorenz ^a   Schlagenhauf, Florian ^a   Beck, Anne ^a   Mell, Thomas ^a   Bahr, Gerd ^a   Buchholz, Hans Georg ^b   Plotkin, Michail ^a   Buchert, Ralph ^a   Kumakura, Yoshitaka ^c   Cumming, Paul ^d   Heinz, Andreas ^a   Rapp, Michael A ^a,e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c KANTO ROSAI HOSPITAL   (Japan)

^d UNIVERSITY OF MUNICH   (Germany)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Ageing; Biological parametric mapping; Cognitive speed; Dopamine

Indexed keywords

6 FLUORODOPA F 18; CATECHOLAMINE;

ADULT; AGING; ARTICLE; BRAIN ATROPHY; BRAIN MAPPING; BRAIN REGION; CATECHOLAMINE SYNTHESIS; COGNITIVE DEFECT; COMPUTED TOMOGRAPHY SCANNER; CORRELATION COEFFICIENT; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; MALE; NEUROIMAGING; NORMAL HUMAN; PARAMETRIC TEST; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; VOXEL BASED MORPHOMETRY;

ADULT; AGING; ATROPHY; COGNITION; DOPAMINE; HUMANS; MALE; MIDDLE AGED; PREFRONTAL CORTEX; TIME FACTORS; YOUNG ADULT;

EID: 84865619996     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2162-4     Document Type: Article

References (21)

1. I Vernaleken HG Buchholz Y Kumakura T Siessmeier P Stoeter P Bartenstein, et al. 2007 'Prefrontal' cognitive performance of healthy subjects positively correlates with cerebral FDOPA influx: an exploratory [18F]-fluoro-L-DOPA-PET investigation Hum Brain Mapp 28 931 939 10.1002/hbm.20325 17133402 10.1002/hbm.20325
2. MN Braskie CE Wilcox SM Landau JP O'Neil SL Baker CM Madison, et al. 2008 Relationship of striatal dopamine synthesis capacity to age and cognition J Neurosci 28 14320 14328 10.1523/JNEUROSCI.3729-08.2008 19109513 10.1523/JNEUROSCI.3729-08.2008 1:CAS:528:DC%2BD1MXis1eqtQ%3D%3D
3. R Cools SE Gibbs A Miyakawa W Jagust M D'Esposito 2008 Working memory capacity predicts dopamine synthesis capacity in the human striatum J Neurosci 28 1208 1212 10.1523/JNEUROSCI.4475-07.2008 18234898 10.1523/JNEUROSCI.4475-07. 2008 1:CAS:528:DC%2BD1cXhvVSksbo%3D
4. P Jokinen A Bruck S Aalto S Forsback R Parkkola JO Rinne 2009 Impaired cognitive performance in Parkinson's disease is related to caudate dopaminergic hypofunction and hippocampal atrophy Parkinsonism Relat Disord 15 88 93 10.1016/j.parkreldis.2008.03.005 18434233 10.1016/j.parkreldis.2008.03.005
5. TA Salthouse 1992 Cognition and context Sci 257 982 983 10.1126/science.257.5072.982-a 10.1126/science.257.5072.982-a 1:STN:280:DC%2BC3cvjt1yltA%3D%3D
6. L Backman N Ginovart RA Dixon TB Wahlin A Wahlin C Halldin, et al. 2000 Age-related cognitive deficits mediated by changes in the striatal dopamine system Am J Psychiatry 157 635 637 10739428 10.1176/appi.ajp.157.4.635 1:STN:280:DC%2BD3c3gsVSrsg%3D%3D
7. Y Kumakura I Vernaleken HG Buchholz P Borghammer E Danielsen G Grunder, et al. 2010 Age-dependent decline of steady state dopamine storage capacity of human brain: an FDOPA PET study Neurobiol Aging 31 447 463 10.1016/j. neurobiolaging.2008.05.005 18541344 10.1016/j.neurobiolaging.2008.05.005 1:CAS:528:DC%2BC3cXntVWqsQ%3D%3D
8. N Raz U Lindenberger KM Rodrigue KM Kennedy D Head A Williamson, et al. 2005 Regional brain changes in aging healthy adults: general trends, individual differences and modifiers Cereb Cortex 15 1676 1689 10.1093/cercor/bhi044 15703252 10.1093/cercor/bhi044
9. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute, November 2002.
10. SF Morgan J Wheelock 1995 Comparability of WAIS-R Digit Symbol and the Symbol Digit Modalities Test Percept Mot Skills 80 631 634 7675604 10.2466/pms.1995.80.2.631 1:STN:280:DyaK2Mvgs1SisQ%3D%3D
11. J Ashburner KJ Friston 2005 Unified segmentation Neuroimage 26 839 851 10.1016/j.neuroimage.2005.02.018 15955494 10.1016/j.neuroimage.2005.02.018
12. C Svarer K Madsen SG Hasselbalch LH Pinborg S Haugbol VG Frokjaer, et al. 2005 MR-based automatic delineation of volumes of interest in human brain PET images using probability maps Neuroimage 24 969 979 10.1016/j.neuroimage.2004. 10.017 15670674 10.1016/j.neuroimage.2004.10.017
13. Y Kumakura P Cumming 2009 PET studies of cerebral levodopa metabolism: a review of clinical findings and modeling approaches Neuroscientist 15 635 650 10.1177/1073858409338217 19793723 10.1177/1073858409338217 1:CAS:528: DC%2BD1MXhs1SlurjI
14. EC Klostermann MN Braskie SM Landau JP O'Neil WJ Jagust 2012 Dopamine and frontostriatal networks in cognitive aging Neurobiol Aging 33 623 e15 e24 10.1016/j.neurobiolaging.2011.03.002 21511369
15. WD Brown MD Taylor AD Roberts TR Oakes MJ Schueller JE Holden, et al. 1999 FluoroDOPA PET shows the nondopaminergic as well as dopaminergic destinations of levodopa Neurology 53 1212 1218 10522875 10.1212/WNL.53.6.1212 1:CAS:528:DyaK1MXntVWhsbo%3D
16. Y Kumakura EH Danielsen A Gjedde I Vernaleken HG Buchholz A Heinz, et al. 2010 Elevated [(18)F]FDOPA utilization in the periaqueductal gray and medial nucleus accumbens of patients with early Parkinson's disease Neuroimage 49 2933 2939 10.1016/j.neuroimage.2009.11.035 19941962 10.1016/j.neuroimage.2009.11.035 1:CAS:528:DC%2BC3cXktlSkt7Y%3D
17. N Pavese BS Simpson V Metta A Ramlackhansingh KR Chaudhuri DJ Brooks 2012 [18F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [18F]FDOPA and [11C]DASB PET study in Parkinson's disease Neuroimage 59 1080 1084 10.1016/j.neuroimage.2011.09.034 21963917 10.1016/j.neuroimage.2011.09.034 1:CAS:528:DC%2BC3MXhsFKgtLfJ
18. P Cumming V Ljubic-Thibal C Laliberte M Diksic 1997 The effect of unilateral neurotoxic lesions to serotonin fibres in the medial forebrain bundle on the metabolism of [3H]DOPA in the telencephalon of the living rat Brain Res 747 60 69 9042528 10.1016/S0006-8993(96)01227-9 1:CAS:528:DyaK2sXktlyjtw%3D%3D
19. DJ Doudet P Rosa-Neto OL Munk TJ Ruth S Jivan P Cumming 2006 Effect of age on markers for monoaminergic neurons of normal and MPTP-lesioned rhesus monkeys: a multi-tracer PET study Neuroimage 30 26 35 10.1016/j.neuroimage.2005. 09.044 16378735 10.1016/j.neuroimage.2005.09.044
20. P Devoto G Flore 2006 On the origin of cortical dopamine: is it a co-transmitter in noradrenergic neurons? Curr Neuropharmacol 4 115 125 18615131 10.2174/157015906776359559 1:CAS:528:DC%2BD28XivVWmsbc%3D
21. L Bäckman S Karlsson H Fischer P Karlsson Y Brehmer A Rieckmann 2011 Dopamine D(1) receptors and age differences in brain activation during working memory Neurobiol Aging 32 1849 1856 10.1016/j.neurobiolaging.2009.10.018 19962789 10.1016/j.neurobiolaging.2009.10.018