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Volumn 37, Issue 7, 2012, Pages 412-421

A review of abuse-deterrent opioids for chronic nonmalignant pain

Author keywords

[No Author keywords available]

Indexed keywords

ACURACET; BUPRENORPHINE PLUS NALOXONE; FENTANYL; HYDROCODONE BITARTRATE PLUS PARACETAMOL; HYDROMORPHONE; MORPHINE SULFATE PLUS NALTREXONE; NALOXONE PLUS OXYCODONE; NICOTINIC ACID PLUS OXYCODONE; NKTR 181; OPIATE; OXYCODONE; OXYCODONE PLUS PARACETAMOL; OXYMORPHONE; OXYTREX; TAPENTADOL; TAPRENEPAG ISOPROPYL ESTER; UNCLASSIFIED DRUG;

EID: 84865613820     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (74)

References (51)
  • 1
    • 80053201781 scopus 로고    scopus 로고
    • Institute of Medicine, Washington, D.C.: National Academies of Science; June 29, 2011. Available at, Accessed December 16
    • Institute of Medicine. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. Washington, D.C.: National Academies of Science; June 29, 2011. Available at: www.iom.edu//media/Files/Report%20Files/2011/Relieving-Pain-in-America-A-Blueprint-for-Transforming-Prevention-Care-Education-Research/Pain%20 Research%202011%20Report%20Brief.pdf. Accessed December 16, 2011.
    • (2011) Relieving Pain In America: A Blueprint For Transforming Prevention, Care, Education, and Research
  • 2
    • 68449088153 scopus 로고    scopus 로고
    • Multimodal analgesia for chronic pain: Rationale and future directions
    • Argoff CE, Albrecht P, Irving G, Rice F. Multimodal analgesia for chronic pain: Rationale and future directions. Pain Med 2009;10(S2):S52-S66.
    • (2009) Pain Med , vol.10 , Issue.2 S
    • Argoff, C.E.1    Albrecht, P.2    Irving, G.3    Rice, F.4
  • 3
    • 68449088799 scopus 로고    scopus 로고
    • Long-acting opioids and short-acting opioids: Appropriate use in chronic pain management
    • Fine PG, Mahajan G, McPherson ML. Long-acting opioids and short-acting opioids: Appropriate use in chronic pain management. Pain Med 2009;10(S2):S79-S88.
    • (2009) Pain Med , vol.10 , Issue.2 S
    • Fine, P.G.1    Mahajan, G.2    McPherson, M.L.3
  • 4
    • 65949103976 scopus 로고    scopus 로고
    • Complex interplay of participants in opioid therapy
    • Bernstein D, Stowell AW, Haggard R, et al. Complex interplay of participants in opioid therapy. Pract Pain Manage 2007;7:10-36.
    • (2007) Pract Pain Manage , vol.7 , pp. 10-36
    • Bernstein, D.1    Stowell, A.W.2    Haggard, R.3
  • 5
    • 84865648347 scopus 로고    scopus 로고
    • National Institute on Drug Abuse (NIDA), Bethesda, Md.: U.S. Department of Health and Human Services, 2005. NIH Pub. No. 05-0580. Available at, Accessed November 1
    • National Institute on Drug Abuse (NIDA). NIDA Community Drug Alert Bulletin: Prescription Drugs. Bethesda, Md.: U.S. Department of Health and Human Services, 2005. NIH Pub. No. 05-0580. Available at: http://archives.drugabuse.gov/prescripalert/. Accessed November 1, 2011.
    • (2011) NIDA Community Drug Alert Bulletin: Prescription Drugs
  • 6
    • 33644929981 scopus 로고    scopus 로고
    • Pain and aberrant drug-related behaviors in medically ill patients with and without histories of substance abuse
    • Passik SD, Kirsh KL, Donaghy KB, Portenoy RK. Pain and aberrant drug-related behaviors in medically ill patients with and without histories of substance abuse. Clin J Pain 2006;22(2):173-181.
    • (2006) Clin J Pain , vol.22 , Issue.2 , pp. 173-181
    • Passik, S.D.1    Kirsh, K.L.2    Donaghy, K.B.3    Portenoy, R.K.4
  • 8
    • 77956076519 scopus 로고    scopus 로고
    • Opioid formulations designed to resist/deter abuse
    • Raffa RB, Pergolizzi JV Jr. Opioid formulations designed to resist/deter abuse. Drugs 2010;70(13):1657-1675.
    • (2010) Drugs , vol.70 , Issue.13 , pp. 1657-1675
    • Raffa, R.B.1    Pergolizzi Jr., J.V.2
  • 9
    • 68449100511 scopus 로고    scopus 로고
    • Update on abuse-resistant and abuse-deterrent approaches to opioid formulations
    • Webster L. Update on abuse-resistant and abuse-deterrent approaches to opioid formulations. Pain Med 2009;10(S2):S124-S133.
    • (2009) Pain Med , vol.10 , Issue.2 S
    • Webster, L.1
  • 10
    • 34648813683 scopus 로고    scopus 로고
    • Challenges in the development of prescription opioid abuse-deterrent formulations
    • Katz NP, Adams EH, Chilcoat H, et al. Challenges in the development of prescription opioid abuse-deterrent formulations. Clin J Pain 2007;23(8):648-660.
    • (2007) Clin J Pain , vol.23 , Issue.8 , pp. 648-660
    • Katz, N.P.1    Adams, E.H.2    Chilcoat, H.3
  • 11
    • 44949084623 scopus 로고    scopus 로고
    • Abuse-deterrent opioid formulations: Are they a pipe dream?
    • Katz N. Abuse-deterrent opioid formulations: Are they a pipe dream? Curr Rheumatol Rep 2008;10:11-18.
    • (2008) Curr Rheumatol Rep , vol.10 , pp. 11-18
    • Katz, N.1
  • 12
    • 84865613762 scopus 로고    scopus 로고
    • Suboxone (buprenorphine and naloxone) Sublingual Tablets, prescribing information. Richmond, Va.: Reckitt Benckiser; December 2011. Available at, Accessed February 3
    • Suboxone (buprenorphine and naloxone) Sublingual Tablets, prescribing information. Richmond, Va.: Reckitt Benckiser; December 2011. Available at: www.suboxone.com/pdfs/SuboxonePI_tablet.pdf. Accessed February 3, 2012.
    • (2012)
  • 13
    • 42249090335 scopus 로고    scopus 로고
    • Opioid antagonists, partial agonists, and agonists/antagonists: The role of office-based detoxification
    • Helm S, Trescot A, Colson J, et al. Opioid antagonists, partial agonists, and agonists/antagonists: The role of office-based detoxification. Pain Physician 2008;11:225-235.
    • (2008) Pain Physician , vol.11 , pp. 225-235
    • Helm, S.1    Trescot, A.2    Colson, J.3
  • 14
    • 64949102344 scopus 로고    scopus 로고
    • Buprenorphine/naloxone: A review of its use in the treatment of opioid dependence
    • Orman JS, Keating GM. Buprenorphine/naloxone: A review of its use in the treatment of opioid dependence. Drugs 2009;69(5):577-607.
    • (2009) Drugs , vol.69 , Issue.5 , pp. 577-607
    • Orman, J.S.1    Keating, G.M.2
  • 15
    • 84865625896 scopus 로고    scopus 로고
    • Embeda (morphine sulfate and naltrexone HCl) Extended Release Capsules, prescribing information. Bristol, Tenn.: King Pharmaceuticals, Inc.; July 2010. Available at, Accessed February 3
    • Embeda (morphine sulfate and naltrexone HCl) Extended Release Capsules, prescribing information. Bristol, Tenn.: King Pharmaceuticals, Inc.; July 2010. Available at: http://labeling.pfizer.com/ShowLabeling.aspx?id=694. Accessed February 3, 2012.
    • (2012)
  • 16
    • 77952127542 scopus 로고    scopus 로고
    • Morphine/naltrexone
    • Duggan ST, Scott LJ. Morphine/naltrexone. CNS Drugs 2010; 24(6):527-538.
    • (2010) CNS Drugs , vol.24 , Issue.6 , pp. 527-538
    • Duggan, S.T.1    Scott, L.J.2
  • 17
    • 84865613761 scopus 로고    scopus 로고
    • Morphine/naltrexone combo temporarily withdrawn, Medscape News. Available at, Accessed November 1
    • Morphine/naltrexone combo temporarily withdrawn. Medscape News. Available at: www.medscape.com/viewarticle/739008. Accessed November 1, 2011.
    • (2011)
  • 18
    • 84865613763 scopus 로고    scopus 로고
    • FDA approves tamper-resistant oxymorphone formulation. Medscape News. Available at, Accessed December 1
    • FDA approves tamper-resistant oxymorphone formulation. Medscape News. Available at: www.medscape.com/viewarticle/755260?src=rss. Accessed December 1, 2011.
    • (2011)
  • 19
    • 84865644385 scopus 로고    scopus 로고
    • Grünenthal Group. Grünenthal's INTAC technology. Available at, Accessed December 1
    • Grünenthal Group. Grünenthal's INTAC technology. Available at: http://grunenthal.com/grt-web/Grunenthal_Group/Research_&_Development/Preclinical_R&D/Novel_drug_delivery_systems/Intac%E2%84%A2_/127701579.jsp;jsessionid=6129785B71A327F8D837E62F62B7B7DE.drp1. Accessed December 1, 2011.
    • (2011)
  • 20
    • 84865642102 scopus 로고    scopus 로고
    • (oxymorphone HCl), Chadds Ford, Pa.: Endo; December 2011. Available at, Accessed February 3
    • Opana ER (oxymorphone HCl) Extended-Release Tablets, prescribing information. Chadds Ford, Pa.: Endo; December 2011. Available at: www.endo.com/pdf/products/Opana%20ER%20PI%2020111212.pdf. Accessed February 3, 2012.
    • (2012) Extended-Release Tablets, Prescribing Information
    • Opana, E.R.1
  • 21
    • 84865614801 scopus 로고    scopus 로고
    • Exalgo (hydromorphone HCl) Extended-Release Tablets, prescribing information. Hazelwood, Mo.: Mallinckrodt; November 2010. Available at, Accessed December 23
    • Exalgo (hydromorphone HCl) Extended-Release Tablets, prescribing information. Hazelwood, Mo.: Mallinckrodt; November 2010. Available at: www.exalgo.com/media/pdf/exalgo-FullPrescribingInformation.pdf. Accessed December 23, 2011.
    • (2011)
  • 22
    • 77949633235 scopus 로고    scopus 로고
    • OROS hydromorphone prolonged release: A review of its use in the management of chronic, moderate to severe pain
    • Carter N, Keating G. OROS hydromorphone prolonged release: A review of its use in the management of chronic, moderate to severe pain. CNS Drugs 2010;24(4):337-361.
    • (2010) CNS Drugs , vol.24 , Issue.4 , pp. 337-361
    • Carter, N.1    Keating, G.2
  • 23
    • 84865614800 scopus 로고    scopus 로고
    • FDA. Information for healthcare professionals: Hydromorphone hydrochloride extended-release capsules (marketed as Palladone). Available at, Accessed December 1
    • FDA. Information for healthcare professionals: Hydromorphone hydrochloride extended-release capsules (marketed as Palladone). Available at: www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm129288.htm. Accessed December 1, 2011.
    • (2011)
  • 24
    • 33847607152 scopus 로고    scopus 로고
    • Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone
    • Sathyan G, Xu E, Thipphawong J, Gupta SK. Pharmacokinetic investigation of dose proportionality with a 24-hour controlled-release formulation of hydromorphone. BMC Clin Pharmacol 2007;7(3):1-8.
    • (2007) BMC Clin Pharmacol , vol.7 , Issue.3 , pp. 1-8
    • Sathyan, G.1    Xu, E.2    Thipphawong, J.3    Gupta, S.K.4
  • 25
    • 0036242279 scopus 로고    scopus 로고
    • Dose conversion and titration with a novel, once-daily, OROS osmotic technology, extended-release hydromorphone formulation in the treatment of chronic malignant or nonmalignant pain
    • Palangio M, Northfelt DW, Portenoy RK, et al. Dose conversion and titration with a novel, once-daily, OROS osmotic technology, extended-release hydromorphone formulation in the treatment of chronic malignant or nonmalignant pain. J Pain Symptom Manage 2002;23(5):355-368.
    • (2002) J Pain Symptom Manage , vol.23 , Issue.5 , pp. 355-368
    • Palangio, M.1    Northfelt, D.W.2    Portenoy, R.K.3
  • 26
    • 84865625899 scopus 로고    scopus 로고
    • New OxyContin (oxycodone controlled-release) formulation
    • New OxyContin (oxycodone controlled-release) formulation. Pharmacist Lett Prescriber Lett 2010;26(12):261201.
    • (2010) Pharmacist Lett Prescriber Lett , vol.26 , Issue.12 , pp. 261201
  • 27
    • 77956707359 scopus 로고    scopus 로고
    • Abuse-deterrent and tamper-resistant opioid formulations: What is their role in addressing prescription opioid abuse?
    • Schneider JP, Matthews M, Jamison RN. Abuse-deterrent and tamper-resistant opioid formulations: What is their role in addressing prescription opioid abuse? CNS Drugs 2010; 24(10):805-810.
    • (2010) CNS Drugs , vol.24 , Issue.10 , pp. 805-810
    • Schneider, J.P.1    Matthews, M.2    Jamison, R.N.3
  • 28
    • 84865644387 scopus 로고    scopus 로고
    • Oxycontin (oxycodone HCl) Controlled-Release Tablets, prescribing information. Stamford, Conn.: Purdue Pharma LP; November 2007. Available at, Accessed January 1
    • Oxycontin (oxycodone HCl) Controlled-Release Tablets, prescribing information. Stamford, Conn.: Purdue Pharma LP; November 2007. Available at: www.accessdata.fda.gov/drug-satfda_docs/label/2009/020553s060lbl.pdf. Accessed January 1, 2012.
    • (2012)
  • 29
    • 84865644386 scopus 로고    scopus 로고
    • FDA okays new abuse-resistant opioid
    • June 20, 2011. Available at, Accessed December 23
    • Fiore K. FDA okays new abuse-resistant opioid. MedPage Today, June 20, 2011. Available at: www.medpagetoday.com/ProductAlert/Prescriptions/27157. Accessed December 23 2011.
    • (2011) MedPage Today
    • Fiore, K.1
  • 30
    • 84865625898 scopus 로고    scopus 로고
    • FDA approves tamper-resistant oxycodone, Medscape Medical News, WebMD; June 20, 2011. Available at, Accessed December 23
    • FDA approves tamper-resistant oxycodone. Medscape Medical News, WebMD; June 20, 2011. Available at: www.medscape.com/viewarticle/744935. Accessed December 23, 2011.
    • (2011)
  • 31
    • 84865636746 scopus 로고    scopus 로고
    • Aversion technology. Acura. Available at, Accessed December 23
    • Aversion technology. Acura. Available at: http://acurapharm.com/research-development/aversion-technology. Accessed December 23, 2011.
    • (2011)
  • 32
    • 84865613764 scopus 로고    scopus 로고
    • Oxecta Tablets. Available at, Accessed December 23
    • Oxecta Tablets. Available at: http://acurapharm.com/products/acurox-without-niacin-tablets. Accessed December 23, 2011.
    • (2011)
  • 33
    • 84865644392 scopus 로고    scopus 로고
    • FDA approves Pfizer pain drug
    • June 21, Available at, Accessed December 14
    • Adams B. FDA approves Pfizer pain drug Oxecta. InPharm, June 21, 2011. Available at: www.inpharm.com/news/160392/fda-approves-pfizer-pain-drug-oxecta. Accessed December 14, 2011.
    • (2011) Oxecta. InPharm
    • Adams, B.1
  • 34
    • 84865625900 scopus 로고    scopus 로고
    • Oxecta (oxycodone HCl, USP) Tablets, prescribing information. Bristol, Tenn.: King Pharmaceuticals, Inc.; June 2011. Available at, Accessed December 23
    • Oxecta (oxycodone HCl, USP) Tablets, prescribing information. Bristol, Tenn.: King Pharmaceuticals, Inc.; June 2011. Available at: http://labeling.pfizer.com/ShowLabeling.aspx?id=620. Accessed December 23, 2011.
    • (2011)
  • 35
    • 84865636745 scopus 로고    scopus 로고
    • Acuracet tablets. Acura. Available at, Accessed December 23
    • Acuracet tablets. Acura. Available at: http://acurapharm.com/products/acuracet-tablets. Accessed December 23, 2011.
    • (2011)
  • 36
    • 84865644390 scopus 로고    scopus 로고
    • Vycavert tablets. Acura. Available at, Accessed December 23
    • Vycavert tablets. Acura. Available at: http://acurapharm.com/products/vycavert-tablets. Accessed December 23, 2011.
    • (2011)
  • 37
    • 47549101405 scopus 로고    scopus 로고
    • Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling
    • Largent-Milnes TM, Guo W, Wang HY, et al. Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling. J Pain 2008; 9(8):700-713.
    • (2008) J Pain , vol.9 , Issue.8 , pp. 700-713
    • Largent-Milnes, T.M.1    Guo, W.2    Wang, H.Y.3
  • 38
    • 34548285495 scopus 로고    scopus 로고
    • Oxytrex: An oxycodone and ultra-low-dose naltrexone formulation
    • Webster LR. Oxytrex: An oxycodone and ultra-low-dose naltrexone formulation. Exp Opin Investig Drugs 2007;16(8):1277-1283.
    • (2007) Exp Opin Investig Drugs , vol.16 , Issue.8 , pp. 1277-1283
    • Webster, L.R.1
  • 39
    • 33845186402 scopus 로고    scopus 로고
    • Oxytrex minimizes physical dependence while providing effective analgesia: A randomized controlled trial in low back pain
    • Webster LR, Butera PG, Moran LV, et al. Oxytrex minimizes physical dependence while providing effective analgesia: A randomized controlled trial in low back pain. J Pain 2006; 7 (12):937-946.
    • (2006) J Pain , vol.7 , Issue.12 , pp. 937-946
    • Webster, L.R.1    Butera, P.G.2    Moran, L.V.3
  • 40
    • 84865644389 scopus 로고    scopus 로고
    • Collegium Pharmaceutical. Technology introduction. Available at, Accessed December 13
    • Collegium Pharmaceutical. Technology introduction. Available at: www.collegiumpharma.com/technology-introduction. Accessed December 13, 2011.
    • (2011)
  • 41
    • 84865636744 scopus 로고    scopus 로고
    • Collegium Pharmaceutical. DETERx formulation design. Available at, Accessed December 13
    • Collegium Pharmaceutical. DETERx formulation design. Available at: www.collegiumpharma.com/deterxatrade-formulation-design. Accessed December 13, 2011.
    • (2011)
  • 42
    • 84865636748 scopus 로고    scopus 로고
    • Collegium Pharmaceutical. DETERx tamper resistance. Available a, Accessed December 13
    • Collegium Pharmaceutical. DETERx tamper resistance. Available at: www.collegiumpharma.com/deterx-tamper-resistance. Accessed December 13, 2011.
    • (2011)
  • 43
    • 84865644391 scopus 로고    scopus 로고
    • Collegium Pharmaceutical, Inc., announces successful type A meeting with FDA for tamper-resistant, extended-release opioid. Business Week, September 26, 2011. Available at, Accessed December 23
    • Collegium Pharmaceutical, Inc., announces successful type A meeting with FDA for tamper-resistant, extended-release opioid. Business Week, September 26, 2011. Available at: http://investing.businessweek.com/research/stocks/private/snapshot.asp?privcapId=7490189. Accessed December 23, 2011.
    • (2011)
  • 44
    • 84865625902 scopus 로고    scopus 로고
    • Collegium Pharmaceutical. Products/pipeline. Available at, Accessed December 23
    • Collegium Pharmaceutical. Products/pipeline. Available at: www.collegiumpharma.com/productspipeline. Accessed December 23, 2011.
    • (2011)
  • 45
    • 84865613765 scopus 로고    scopus 로고
    • Nektar Therapeutics, Product Fact Sheet, 2011. CNS/PAIN-NKTR-181: New mu-opioid analgesic with novel molecular structure in clinical development as a safer, abuse-deterrent pain therapeutic. Available at, Accessed December 13
    • Nektar Therapeutics, Product Fact Sheet, 2011. CNS/PAIN-NKTR-181: New mu-opioid analgesic with novel molecular structure in clinical development as a safer, abuse-deterrent pain therapeutic. Available at: www.nektar.com/pdf/pipeline/NKTR-181/product_fact_sheet.pdf. Accessed December 13, 2011.
    • (2011)
  • 46
    • 84865644393 scopus 로고    scopus 로고
    • Nektar announces positive clinical data from second phase 1 clinical study of NKTR-181, a novel opioid analgesic molecule to treat chronic pain
    • December 13, 2011, Available at, Accessed December 13
    • Nektar announces positive clinical data from second phase 1 clinical study of NKTR-181, a novel opioid analgesic molecule to treat chronic pain. Daily Markets December 13, 2011. Available at: www.dailymarkets.com/stock/2011/12/13/nektar-announces-positive-clinical-data-from-second-phase-1-clinical-study-of-nktr-181-a-novel-opioid-analgesic-molecule-to-treat-chronic-pain. Accessed December 13, 2011.
    • (2011) Daily Markets
  • 47
    • 84865644394 scopus 로고    scopus 로고
    • Nektar/PR Newswire. Nektar announces that FDA grants fast track designation to NKTR-181, a new oral opioid analgesic molecule for the treatment of moderate-to-severe chronic pain, June 7, 2012. Available at, Accessed June 18
    • Nektar/PR Newswire. Nektar announces that FDA grants fast track designation to NKTR-181, a new oral opioid analgesic molecule for the treatment of moderate-to-severe chronic pain, June 7, 2012. Available at: http://ir.nektar.com/releasedetail.cfm?ReleaseId=681109. Accessed June 18, 2012.
    • (2012)
  • 48
    • 84865644398 scopus 로고    scopus 로고
    • Pharmaco Fore. Pipeline: Moderateto severe pain. Available at, Accessed December 13
    • Pharmaco Fore. Pipeline: Moderateto severe pain. Available at: www.pharmacofore.com/view.cfm/39/Moderate-to-Severe-Pain. Accessed December 13, 2011.
    • (2011)
  • 49
    • 84865644397 scopus 로고    scopus 로고
    • Companies attempt abuse-proof opioids
    • April 13, 2011. Available at
    • Fiore K. Companies attempt abuse-proof opioids. MedPage Today, April 13, 2011. Available at: www.medpagetoday.com/Psychiatry/Addictions/25888. Accessed December 13, 2011.
    • MedPage Today
    • Fiore, K.1
  • 50
    • 84912043636 scopus 로고    scopus 로고
    • PharmacoFore. PharmacoFore, Inc. announces positive results from a phase I clinical study of its hydromorphone Bio-Activated Molecular Delivery™ system and upcoming presentation at the 2011 BIO Business Forum during the annual BIO International Convention in Washington, D.C.; June 23
    • PharmacoFore. PharmacoFore, Inc. announces positive results from a phase I clinical study of its hydromorphone Bio-Activated Molecular Delivery™ system and upcoming presentation at the 2011 BIO Business Forum during the annual BIO International Convention in Washington, D.C.; June 23, 2011. Accessed December 14, 2011.
    • (2011) Accessed December , vol.14 , pp. 2011
  • 51
    • 84865636747 scopus 로고    scopus 로고
    • Durect Corp. Primary endpoint of pivotal phase III clinical trial achieved for Remoxy, December 6, 2007. Available at, Accessed December 7
    • Durect Corp. Primary endpoint of pivotal phase III clinical trial achieved for Remoxy, December 6, 2007. Available at: www.durect.com/wt/durect/page_name/pr_1196960615. Accessed December 7, 2011.
    • (2011)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.