Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 7, 2012, Pages 3490-3500

  Tonari, Masahiro ^a   Kurimoto, Takuji ^a   Horie, Taeko ^a   Sugiyama, Tetsuya ^a   Ikeda, Tsunehiko ^a   Oku, Hidehiro ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD68 ANTIGEN; CYCLO (DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); CYTOKINE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; N (2, 6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CD68 PROTEIN, RAT; CYCLO(TRP ASP PRO VAL LEU); CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; DIFFERENTIATION ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUKOCYTE ANTIGEN; MESSENGER RNA; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NOS2 PROTEIN, RAT; OLIGOPEPTIDE; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; INCIDENCE; MACROPHAGE; MALE; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NITROSATIVE STRESS; NONHUMAN; OPTIC NERVE; OPTIC NERVE INJURY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; CELL SURVIVAL; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CRUSH; NERVE REGENERATION; OPTIC NEURITIS; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL SURVIVAL; ENDOTHELIN-1; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; MACROPHAGES; MALE; MICROGLIA; NERVE CRUSH; NERVE REGENERATION; NITRIC OXIDE SYNTHASE TYPE II; OLIGOPEPTIDES; OPTIC NERVE INJURIES; OPTIC NEURITIS; PEPTIDES, CYCLIC; PIPERIDINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RETINAL GANGLION CELLS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84865589482     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-9415     Document Type: Article

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