Costimulation blockade - A double-edged sword?

American Journal of Transplantation

Volumn 12, Issue 9, 2012, Pages 2269-2270

  Maltzman, J S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; BASILIXIMAB; BELATACEPT; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4LG; FC RECEPTOR; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; CARDIAC GRAFT REJECTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR IMMUNITY; COSTIMULATION BLOCKADE; CYTOKINE PRODUCTION; DRUG EFFICACY; EDITORIAL; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 84865588835     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04185.x     Document Type: Editorial

References (6)

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2. Bour-Jordan H, Bluestone JA,. Regulating the regulators: Costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev 2009; 229: 41-66.
3. Riella LV, Liu T, Yang J, et al,. Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model. Am J Transplant 2012; 12: 846-855.
4. Charbonnier L-M, Vokaer B, LemaÃtre PH, Field KA, Leo O, Le Moine A,. CTLA4-Ig restores rejection of MHC class-II mismatched allografts by disabling IL-2-expanded regulatory T cells. Am J Transplant 2012; 12: 2313-2321.
5. Bluestone JA, Liu W, Yabu JM, et al,. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant 2008; 8: 2086-2096.
6. Bestard O, Cassis L, Cruzado JM, et al,. Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int 2011; 24: 451-460.