Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism

Biochemical Journal

Volumn 446, Issue 3, 2012, Pages 395-404

  Cheng, Kuo Chang ^a   Liao, Jhen Ni ^a   Lyu, Ping Chiang ^a,b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Arylalkylamine N acetyltransferase (AANAT); Catalytic triad; Dopamine N acetyltransferase (Dat); Melatonin; Single wavelength anomalous diffraction

Indexed keywords

ACETYL COENZYME A; ACYLTRANSFERASE; DOPAMINE N ACETYLTRANSFERASE ACETYL COENZYME A; GLUTAMINE; SELENIUM; SERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DIFFRACTION; DROSOPHILA MELANOGASTER; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; MUTAGENESIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ACETYL COENZYME A; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA PROTEINS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA;

EID: 84865587472     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120520     Document Type: Article

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