Patients with the malignant profile within 3 hours of symptom onset have very poor outcomes after intravenous tissue-type plasminogen activator therapy

Stroke

Volumn 43, Issue 9, 2012, Pages 2494-2496

  Inoue, Manabu ^a   Mlynash, Michael ^a   Straka, Matus ^a   Lansberg, Maarten G ^a   Zaharchuk, Greg ^a   Bammer, Roland ^a   Albers, Gregory W ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

acute stroke; CT perfusion; MRI; PWI; tPA

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; INCIDENCE; MALE; MALIGNANT TRANSFORMATION; PERFUSION; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; PROGNOSIS; RANKIN SCALE; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; STROKE;

AGED; CEREBRAL INFARCTION; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROGNOSIS; ROC CURVE; STROKE; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84865577287     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.653329     Document Type: Article

References (6)

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3. Mlynash M, Lansberg MG, De Silva DA, Lee J, Christensen S, Straka M, et al. Refining the definition of the malignant profile: insights from the DEFUSE-EPITHET pooled data set. Stroke. 2011;42:1270-1275.
4. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. 1995;274:1017-1025.
5. Straka M, Albers GW, Bammer R. Real-time diffusion-perfusion mismatch analysis in acute stroke. J Magn Reson Imaging. 2010;32: 1024-1037.
6. Campbell BC, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke. 2011;42:3435-3440.