Microscopic endometrial perivascular epithelioid cell nodules: a case report with the earliest presentation of a uterine perivascular epithelioid cell tumor

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Fang, Chia Lang ^a,b   Lin, Yun Ho ^a,c   Chen, Wei Yu ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Adenomyosis; CD10; Endometriosis; Lymphangioleiomyomatosis; PEComa; Perivascular epithelioid cell; Tuberous sclerosis

Indexed keywords

HMB 45 PROTEIN, HUMAN; HMB-45 PROTEIN, HUMAN; MELANOMA ANTIGEN; MEMBRANE METALLOENDOPEPTIDASE; TUMOR MARKER;

ADENOMYOSIS; ADULT; ARTICLE; BIOPSY; CASE REPORT; CHEMISTRY; EARLY DIAGNOSIS; ENDOMETRIOSIS; ENDOMETRIUM; EPITHELIOID CELL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHANGIOLEIOMYOMATOSIS; OVARY CYST; PATHOLOGY; PERIVASCULAR EPITHELIOID CELL TUMOR; PRECANCER; PREDICTIVE VALUE; TREATMENT OUTCOME; TUBEROUS SCLEROSIS; UTERUS CANCER;

ADENOMYOSIS; ADULT; BIOPSY; EARLY DETECTION OF CANCER; ENDOMETRIOSIS; ENDOMETRIUM; EPITHELIOID CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHANGIOLEIOMYOMATOSIS; MELANOMA-SPECIFIC ANTIGENS; NEPRILYSIN; OVARIAN CYSTS; PERIVASCULAR EPITHELIOID CELL NEOPLASMS; PRECANCEROUS CONDITIONS; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME; TUBEROUS SCLEROSIS; TUMOR MARKERS, BIOLOGICAL; UTERINE NEOPLASMS;

EID: 84865574816     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-117     Document Type: Article

References (34)

1. Folpe AL. Neoplasms with perivascular epithelioid cell differentiation (PEComas). World Health Organization Classification of Tumors. Pathology and genetics of tumors of soft tissue and bone 2002, 221-222. Lyon: ARC Press, Fletcher CDM, Unni KK, Mertens F.
2. Bonetti F, Pea M, Martignoni G, Zamboni G. PEC and sugar. Am J Surg Pathol 1992, 16:307-308. 10.1097/00000478-199203000-00013, 1599021.
3. Hornick JL, Fletcher CD. PEComa: what do we know so far ?. Histopathology 2006, 48:75-82. 10.1111/j.1365-2559.2005.02316.x, 16359539.
4. Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F. PEComas: the past, the present and the future. Virchows Arch 2008, 452:119-132. 10.1007/s00428-007-0509-1, 2234444, 18080139.
5. Folpe AL, Kwiatkowski DJ. Perivascular epithelioid cell neoplasms: pathology and pathogenesis. Hum Pathol 2010, 41:1-15. 10.1016/j.humpath.2009.05.011, 19604538.
6. Fadare O. Perivascular epithelioid cell tumor (PEComa) of the uterus: an outcome-based clinicopathologic analysis of 41 reported cases. Adv Anat Pathol 2008, 15:63-75. 10.1097/PAP.0b013e31816613b0, 18418088.
7. Sieinski W. Lipomatous neometaplasia of the uterus. Report of 11 cases with discussion of histogenesis and pathogenesis. Int J Gynecol Pathol 1989, 8:357-363. 10.1097/00004347-198912000-00007, 2807714.
8. Gyure KA, Hart WR, Kennedy AW. Lymphangiomyomatosis of the uterus associated with tuberous sclerosis and malignant neoplasia of the female genital tract: a report of two cases. Int J Gynecol Pathol 1995, 14:344-351. 10.1097/00004347-199510000-00010, 8598338.
9. Pea M, Martignoni G, Zamboni G, Bonetti F. Perivascular epithelioid cell. Am J Surg Pathol 1996, 20:1149-1153. 10.1097/00000478-199609000-00012, 8764751.
10. Vang R, Kempson RL. Perivascular epithelioid cell tumor ('PEComa') of the uterus: a subset of HMB-45-positive epithelioid mesenchymal neoplasms with an uncertain relationship to pure smooth muscle tumors. Am J Surg Pathol 2002, 26:1-13. 10.1097/00000478-200201000-00001, 11756764.
11. Fadare O, Parkash V, Yilmaz Y, Mariappan MR, Ma L, Hileeto D, Qumsiyeh MB, Hui P. Perivascular epithelioid cell tumor (PEComa) of the uterine cervix associated with intraabdominal 'PEComatosis': A clinicopathological study with comparative genomic hybridization analysis. World J Surg Oncol 2004, 2:35. 10.1186/1477-7819-2-35, 527874, 15494070.
12. Liang SX, Pearl M, Liu J, Hwang S, Tornos C. "Malignant" uterine perivascular epithelioid cell tumor, pelvic lymph node lymphangioleiomyomatosis, and gynecological pecomatosis in a patient with tuberous sclerosis: a case report and review of the literature. Int J Gynecol Pathol 2008, 27:86-90. 10.1097/pgp.0b013e318150df37, 18156981.
13. Froio E, Piana S, Cavazza A, Valli R, Abrate M, Gardini G. Multifocal PEComa (PEComatosis) of the female genital tract associated with endometriosis, diffuse adenomyosis, and endometrial atypical hyperplasia. Int J Surg Pathol 2008, 16:443-446. 10.1177/1066896908316067, 18499690.
14. Hornick JL, Fletcher CD. Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol 2008, 32:493-501. 10.1097/PAS.0b013e318161dc34, 18223480.
15. Lim GS, Oliva E. The morphologic spectrum of uterine PEC-cell associated tumors in a patient with tuberous sclerosis. Int J Gynecol Pathol 2011, 30:121-128.
16. Yang W, Li G, Wei-qiang Z. Multifocal PEComa (PEComatosis) of the female genital tract and pelvis: a case report and review of the literature. Diag Pathol 2012, 7:23.
17. Pea M, Bonetti F, Zamboni G, Martignoni G, Riva M, Colombari R, Mombello A, Bonzanini M, Scarpa A, Ghimenton C, Fiore-Donati L. Melanocyte-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidney. Pathology 1991, 23:185-188. 10.3109/00313029109063563, 1664078.
18. Pea M, Bonetti F, Zamboni G, Martignoni G, Fiore-Donati L, Doglioni C. Clear cell tumor and angiomyolipoma. Am J Surg Pathol 1991, 15:199-202. 10.1097/00000478-199102000-00020, 2025321.
19. Bonetti F, Pea M, Martignoni G, Zamboni G, Iuzzolino P. Cellular heterogeneity in lymphangiomyomatosis of the lung. Hum Pathol 1991, 22:727-728. 10.1016/0046-8177(91)90298-4, 2071116.
20. Folpe AL, Goodman ZD, Ishak KG, Paulino AF, Taboada EM, Meehan SA, Weiss SW. Clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres. Am J Surg Pathol 2000, 24:1239-1246. 10.1097/00000478-200009000-00007, 10976698.
21. Hendrickson MR, Tavassoli FA, Kempson RL, McCluggage WG, Haller U, Kubik-Huch RA. Perivascular epithelioid cell tumor. World Health Organization Classification of Tumors. Pathology and genetics of tumors of the breast and female genital organs 2003, 243. Lyon: IARC Press, Tavassoli FA, Devilee P.
22. Clay MR, Gibson P, Lowell J, Cooper K. Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm. Int J Gynecol Pathol 2011, 30:71-75. 10.1097/PGP.0b013e3181efe08d, 21131829.
23. Nagashima Y, Ohaki Y, Tanaka Y, Misugi K, Horiuchi M. A case of renal angiomyolipomas associated with multiple and various hamartomatous microlesions [abtract]. Virchows Arch A Pathol Anat Histopathol 1988, 413:177-182. 10.1007/BF00749680, 3133877.
24. Chowdhury PR, Tsuda N, Anami M, Hayashi T, Iseki M, Kishikawa M, Matsuya F, Kanetake H, Saito Y. A histopathologic and immunohistochemical study of small nodules of renal angiomyolipoma: a comparison of small nodules with angiomyolipoma. Mod Pathol 1996, 9:1081-1088.
25. Kiliçaslan I, Güllüoglu MG, Dogan O, Uysal V. Intraglomerular microlesions in renal angiomyolipoma. Hum Pathol 2000, 31:1325-1328. 10.1053/hupa.2000.16533, 11070127.
26. Weinreb I, Howarth D, Latta E, Ghazarian D, Chetty R. Perivascular epithelioid cell neoplasms (PEComas): four malignant cases expanding the histopathological spectrum and a description of a unique finding. Virchows Arch 2007, 450:463-470. 10.1007/s00428-007-0378-7, 17377813.
27. Silva EG, Deavers MT, Bodurka DC, Malpica A. Uterine epithelioid leiomyosarcoma with clear cells. Reactivity with HMB-45 and the concept of PEComa. Am J Surg Pathol 2004, 28:244-249. 10.1097/00000478-200402000-00013, 15043315.
28. Silva EG, Bodurka DC, Scouros MA, Ayala A. A uterine leiomyosarcoma that became positive for HMB45 in the metastasis. Ann Diagn Pathol 2005, 9:43-45. 10.1053/j.anndiagpath.2004.10.011, 15692950.
29. Simpson KW, Albores-Saavedra J. HMB-45 reactivity in conventional uterine leiomyosarcomas. Am J Surg Pathol 2007, 31:95-98. 10.1097/01.pas.0000213346.57391.70, 17197924.
30. Fadare O. Uterine PEComa: appraisal of a controversial and increasingly reported mesenchymal neoplasm. Int Semin Surg Oncol 2008, 5:7. 10.1186/1477-7800-5-7, 2278149, 18325099.
31. Chu PG, Arber DA, Weiss LM, Chang KL. Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparision of 34 cases. Mod Pathol 2001, 14:465-471. 10.1038/modpathol.3880335, 11353058.
32. Greene LA, Mount SL, Schned AR, Cooper K. Recurrent perivascular epithelioid cell tumor of the uterus (PEComa): an immunohistochemical study and review of the literature. Gynecol Oncol 2003, 90:677-681. 10.1016/S0090-8258(03)00325-1, 13678746.
33. Dimmler A, Seitz G, Hohenberger W, Kirchner T, Faller G. Late pulmonary metastasis in uterine PEComa. J Clin Pathol 2003, 56:627-628. 10.1136/jcp.56.8.627, 1770029, 12890819.
34. Maguer-Satta V, Besançon R, Bachelard-Cascales E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem Cells 2011, 29:389-396. 10.1002/stem.592, 21425402.