A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings

Clinical Otolaryngology

Volumn 37, Issue 4, 2012, Pages 261-270

  Loock, J W ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BETAMETHASONE VALERATE; BORIC ACID; CIPROFLOXACIN; CLIOQUINOL; EAR DROPS; GENTAMICIN; QUADRIDERM; SODIUM CHLORIDE; STERILE WATER; TOLNAFTATE; UNCLASSIFIED DRUG;

ADULT; APPLICATION SITE BURNING; ARTICLE; AUDITORY TUBE; CHRONIC OTITIS MEDIA; CONTROLLED STUDY; EARDRUM PERFORATION; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIMARY HEALTH CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; TASTE DISORDER; TERTIARY HEALTH CARE;

ACETIC ACID; ADMINISTRATION, TOPICAL; ADULT; ANALYSIS OF VARIANCE; ANTI-INFECTIVE AGENTS; AUDIOMETRY; BETAMETHASONE 17-VALERATE; BORIC ACIDS; CHI-SQUARE DISTRIBUTION; CHRONIC DISEASE; CIPROFLOXACIN; CLIOQUINOL; DRUG RESISTANCE, BACTERIAL; FEMALE; GENTAMICINS; HEARING LOSS; HUMANS; MALE; OTITIS MEDIA; PROSPECTIVE STUDIES; TOLNAFTATE; TREATMENT OUTCOME;

EID: 84865571435     PISSN: 17494478     EISSN: 17494486     Source Type: Journal    
DOI: 10.1111/j.1749-4486.2012.02532.x     Document Type: Article

References (21)

1. Giles M. & Asher I. (1991) Prevalence and natural history of otitis media with perforation in Maori school children. J. Laryngol. Otol. 105, 257-260.
2. Browning G.G. & Gatehouse S. (1992) The prevalence of middle ear disease in the adult British population. Clin. Otolaryngol. 17, 317-321.
3. Miller M.L. (1979) Epidemiology of otitis media: problem and research focus for geographers. Soc. Sci. Med. 13D, 133-136.
4. Berman S. (1995) Otitis media in developing countries. Pediatrics 96, 126-131.
5. Smith A.W., Hatcher J., Mackenzie I.J. et al. (1996) Randomised controlled trial of treatment of chronic suppurative otitis media in Kenyan schoolchildren. Lancet 348, 1128-1133.
6. Kasemsuwan L. & Clongsuesuek P. (1997) A double-blind prospective trial of topical ciprofloxacin versus normal saline solution in the treatment of otorrhoea. Clin. Otolaryngol. 22, 44-46.
7. Esposito S., D'Enrico G. & Montanaro C. (1990) Topical and oral treatment of chronic otitis media with ciprofloxacin. A preliminary study. Arch. Otolaryngol. Head Neck Surg. 116, 557-559.
8. Esposito S., Noviello S., D'Enrico G. et al. (1992) Topical ciprofloxacin vs intramuscular gentamicin for COM. Arch. Otolaryngol. Head Neck Surg. 118, 842-844.
9. Browning G.G., Gatehouse S. & Calder T. (1998) Medical management of active chronic otitis media: a controlled study. J. Laryngol. Otol. 102, 491-495.
10. Crowther J.A. & Simpson D. (1991) Medical treatment of chronic otitis media: steroid or antibiotic with steroid eardrops? Clin. Otolaryngol. 16, 142-144.
11. Browning G.G., Picozzi G.L., Calder I.T. et al. (1983) Controlled trial of medical treatment of active COM. Br. Med. J. (Clin. Res. Ed.) 287, 1024.
12. Tong M.C.F. & van Hasselt C. (1996) A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. J. Laryngol. Otol. 110, 309-314.
13. Kellerhals B. (1978) Horschaden durch ototoxische ohrtropfen. Ergebnisse Einer Umfrage. HNO (Berlin) 26, 49-52.
14. Fradis M., Brodsky A., Ben-David J. et al. (1997) Chronic otitis media treated topically with ciprofloxacin or tobramycin. Arch. Otolaryngol. Head Neck Surg. 123, 1057-1060.
15. Clayton M., Osborne J., Rutherford D. et al. (1990) A double-blind, randomized, prospective trial of a topical antiseptic versus a topical antibiotic in the treatment of otorrhoea. J. Otolaryngol. 15, 7-10.
16. Thorp M., Kruger J., Oliver S. et al. (1998) The antibacterial acidity of acetic acid and Burow's solution as topical otological preparations. J. Laryngol. Otol. 112, 925-928.
17. Jaya C., Job A., Mathai E., & Antonisamy B. (2003) Evaluation of topical povidone-iodine in chronic suppurative otitis media. Arch. Otolaryngol Head Neck Surg. 129, 1098-1100.
18. Macfadyen C., Gamble C., Garner P. et al. (2005) Topical quinolone vs antiseptic for treating chronic suppurative otitis media: a randomized controlled trial. Tropical Med. Int. Health 10, 190-197.
19. Eason R., Harding E., Nicholson R. et al. (1986) Chronic suppurative otitis media in the Solomon Islands: a prospective, microbiological, audiometric and therapeutic survey. N. Z. Med. J. 99, 812-815.
20. Acuin J. (2004) Chronic Suppurative Otitis Media: Burden of Illness and Management Options: For Child and Adolescent Health Development Prevention of Blindness and deafness. World Health Organisation, Geneva.
21. South African National Department of Health (2005) Guideline for the Prevention of Hearing Impairment Due to Otitis Media at Clinic Level. South African National Department of Health, Pretoria.