Who should receive calcium and vitamin D supplementation?

Age and Ageing

Volumn 41, Issue 5, 2012, Pages 576-580

  Verbrugge, Frederik H ^a,b   Gielen, Evelien ^c,d   Milisen, Koen ^c   Boonen, Steven ^c,d  

^a DEPARTMENT OF CARDIOLOGY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Calcium; Cardiovascular complications; Dietary supplements; Fracture prevention; Myocardial infarction; Osteoporosis; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CITRATE CALCIUM; PLACEBO; VITAMIN D;

ARTICLE; BONE STRENGTH; BONE TURNOVER; CALCIUM INTAKE; CARDIOVASCULAR RISK; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FRAGILITY FRACTURE; HEART INFARCTION; HUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; STROKE; SUDDEN DEATH; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

CALCIUM; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HUMANS; MYOCARDIAL INFARCTION; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; RISK FACTORS; VITAMIN D;

EID: 84865554154     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afs094     Document Type: Article

References (22)

1. Boonen S, Lips P, Bouillon R, Bischoff-Ferrari HA, Vanderschueren D, Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin d supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 2007; 92: 1415-23.
2. Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 2007; 370: 657-66.
3. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. Br Med J 2009; 339: b3692.
4. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA et al. Calcium intake and hip fracture risk in men and women: a meta-analysis of prospective cohort studies and randomized controlled trials. Am J Clin Nutr 2007; 86: 1780-90.
5. DIPART Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. Br Med J 2010; 340: b5463.
6. Grant AM, Avenell A, Campbell MK et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005; 365: 1621-8.
7. Jackson RD, LaCroix AZ, Gass M et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006; 354: 669-83.
8. Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ. Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. EPIDOS Study Group. J Clin Endocrinol Metab 1996; 81: 1129-33.
9. Chapuy MC, Arlot ME, Duboeuf F et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 1992; 327: 1637-42.
10. Masud T, Mulcahy B, Thompson AV et al. Effects of cyclical etidronate combined with calcitriol versus cyclical etidronate alone on spine and femoral neck bone mineral density in postmenopausal osteoporotic women. Ann Rheum Dis 1998; 57: 346-9.
11. Iwamoto J, Takeda T, Sato Y. Prevention and treatment of corticosteroid-induced osteoporosis. Yonsei Med J 2005; 46: 456-63.
12. Bolland MJ, Barber PA, Doughty RN et al. Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. Br Med J 2008; 336: 262-6.
13. Chung M, Balk EM, Brendel M et al. Vitamin D and calcium: a systematic review of health outcomes. Evidence Report No. 183. AHRQ Publication No. 09-E015. Rockville, MD: Agency for Healthcare Research and Quality. August, 2009.
14. Bostick RM, Kushi LH, Wu Y, Meyer KA, Sellers TA, Folsom AR. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999; 149: 151-61.
15. Bolland MJ, Avenell A, Baron JA et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. Br Med J 2010; 341: c3691.
16. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. Br Med J 2011; 342: d2040.
17. Reid IR, Bolland MJ, Avenell A, Grey A. Cardiovascular effects of calcium supplementation. Osteoporos Int 2011; 22: 1649-58.
18. Hsia J, Heiss G, Ren H et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation 2007; 115: 846-54.
19. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL. Calcium supplementation and the risks of atherosclerotic vascular disease in older women: results of a 5-year RCT and a 4.5-year follow-up. J Bone Miner Res 2010; 26: 35-41.
20. Sanders KM, Stuart AL, Williamson EJ et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. J Am Med Assoc 2010; 303: 1815-22.
21. Rossini M, Gatti D, Viapiana O et al. Short-term effects on bone turnover markers of a single high dose of oral vitamin d3. J Clin Endocrinol Metab 2012; 97: E622-6.
22. Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women-a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 2007; 46: 1852-57.