Tumour-derived IL-10 within tumour microenvironment represses the antitumour immunity of Socs1-silenced and sustained antigen expressing DCs

European Journal of Cancer

Volumn 48, Issue 14, 2012, Pages 2252-2259

  Song, Shuxia ^a   Wang, Yue ^b   Wang, Junxia ^a   Lian, Weiguang ^a   Liu, Shufeng ^a   Zhang, Zhengzheng ^a   Liu, Fuying ^a   Wei, Lin ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

DC vaccine; IL 10; Lentiviral vector; Socs1; Tumour microenvironment

Indexed keywords

DENDRITIC CELL VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 4; LENTIVIRUS VECTOR; PROGRAMMED DEATH 1 RECEPTOR; SHORT HAIRPIN RNA; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TYROSINASE RELATED PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CANCER GROWTH; CANCER INFILTRATION; CANCER INHIBITION; CANCER SURVIVAL; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL MATURATION; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EX VIVO STUDY; GENE EXPRESSION; GENE SILENCING; IMMUNOCOMPETENT CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TUMOR GROWTH; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; VACCINATION;

ANIMALS; ANTIGEN PRESENTATION; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DENDRITIC CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; INTERLEUKIN-10; INTRAMOLECULAR OXIDOREDUCTASES; LYMPHOCYTES, TUMOR-INFILTRATING; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RNA INTERFERENCE; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSFECTION; TUMOR BURDEN; TUMOR ESCAPE; TUMOR MICROENVIRONMENT;

EID: 84865504759     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.12.009     Document Type: Article

References (32)

1. R.M. Steinman Dendritic cells: versatile controllers of the immune system Nat Med 13 2007 1155 1159
2. S. Jarnjak-Jankovic, R.D. Pettersen, and S. Saebøe-Larssen Evaluation of dendritic cells loaded with apoptotic cancer cells or expressing tumour mRNA as potential cancer vaccines against leukemia BMC Cancer 5 2005 20
3. Y. He, J. Zhang, and Z. Mi Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity J Immunol 174 2005 3808 3817
4. L. Zhang, J.R. Conejo-Garcia, and D. Katsaros Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer N Engl J Med 34 2003 8203 8213
5. K. Palucka, H. Ueno, and J. Fay Dendritic cells and immunity against cancer J Intern Med 269 2011 64 73
6. Bangxing Hong, Wenhong Ren, and Xiao-Tong Song Human socs1 controls immunostimulatory activity of monocyte derived dendritic cells Cancer Res 69 2009 8076 8084
7. Hong Fu, Shaohua Song, and Fang Liu Dendritic cells transduced with socs1 gene exhibit regulatory DC properties and prolong allograft survival Cell Mol Immunol 6 2009 87 95
8. H. Toshikatsu, T. Kentaro, and M. Yumiko Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene J Immunol 174 2005 4325 4332
9. Y. Akihiko, N. Tetsuji, and K. Masato Socs proteins, cytokine signalling and immune regulation Nat Rev Immunol 7 2007 454 465
10. Q. Hu, X. Qin, and G. Qian Socs1 silencing can break high-dose dendritic cell immunotherapy-induced immune tolerance Mol Med Rep 1 2008 61 70
11. S. Lei, E.K. Kevin, and S. Randy Silencing of socs1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity Nat Biotechnol 22 2004 1546 1553
12. E.K. Kevin, X.T. Song, and M. Aldrich Socs1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling J Clin Invest 116 2006 90 100
13. S. Celli, F. Lemaître, and P. Bousso Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4 T cell activation Immunity 27 2007 625 634
14. N.A. Kukutsch, S. Rossner, and J.M. Austyn Formation and kinetics of MHC class I-ovalbumin peptide complexes on immature and mature murine dendritic cells J Invest Dermatol 115 2000 449 453
15. D. Zehn, C.J. Cohen, and Y. Reiter Extended presentation of specific MHC-peptide complexes by mature dendritic cells compared to other types of antigen-presenting cells Eur J Immunol 34 2004 1551 1560
16. N. Seo, S. Hayakawa, M. Takigawa, and Y. Tokura Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity Immunology 103 2001 449 457
17. H. Nishikawa, and S. Sakaguchi Regulatory T cells in tumor immunity Int J Cancer 127 4 2010 759 767
18. Marc Beyer, and Joachim L. Schultze Regulatory T cells: major players in the tumor microenvironment Curr Pharm Design 15 2009 1879 1892
19. R. Schroers, and S.Y. Chen Lentiviral transduction of human dendritic cells Methods Mol Biol 246 2004 451 459
20. + T cells secretinginterleukin- 10 and transforming growth factor-β1 mediates suppression in the tumor microenvironment Clin Cancer Res 13 2007 4345 4354
21. J. Ozao-Choy, G. Ma, and J. Kao The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies Cancer Res 69 2009 2514 2522
22. S. Song, K. Zhang, and H. You Significant anti-tumour activity of adoptively transferred T cells elicited by intratumoral dendritic cell vaccine injection through enhancing the ratio of CD8+ T cell/regulatory T cells in tumour Clin Exp Immunol 162 2010 75 83
23. E. Gilboa The promise of cancer vaccines Nat Rev Cancer 4 2004 401 411
24. E. Gilboa DC-based cancer vaccines J Clin Invest 117 2007 1195 1203
25. A. Frederick, M.R. Helen, and C. Benjamin Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization Mol Ther 17 2009 1643 1650
26. T. Wang, Q. Jiang, and C. Chan Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR Blood 113 2009 2906 2913
27. A. Lin, A. Schildknecht, and L.T. Nguyen Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth Immunol Lett 127 2010 77 84
28. S.A. Quezada, K.S. Peggs, and T.S. Simpson Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion again established melanoma J Exp Med 205 2008 2125 2138
29. + regulatory T cells J Immunol 177 2006 896 904
30. T.J. Curiel, G. Coukos, and L. Zou Specific recruitment of regulatory T-cells in ovarian carcinoma fosters immune privilege and predicts reduced survival Nat Med 10 2004 942 949
31. H. Fu, S. Song, and F. Liu Dendritic cells transduced with socs1 gene exhibit regulatory DC properties and prolong allograft survival Cell Mol Immunol 6 2009 87 95
32. M. Murai, O. Turovskaya, and G. Kim Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis Nat Immunol 10 2009 1178 1184