메뉴 건너뛰기




Volumn 46, Issue 8, 2012, Pages 637-648

Advances in the management of HER2-positive advanced gastric and gastroesophageal junction cancer

Author keywords

chemotherapy; HER2; herceptin; stomach cancer; trastuzumab

Indexed keywords

CAPECITABINE; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; LAPATINIB; OXALIPLATIN; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE;

EID: 84865499429     PISSN: 01920790     EISSN: 15392031     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3182557307     Document Type: Review
Times cited : (68)

References (82)
  • 1
    • 84873573110 scopus 로고    scopus 로고
    • Globocan 2008 v1.2, cancer incidence and mortality worldwide: IARC CancerBase No. 10 (GLOBOCAN web site)
    • Available at: http:// globocan.iarc.fr. Accessed September 22, 2011.
    • Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 (GLOBOCAN web site). Lyon, France International Agency for Research on Cancer; 2010. Available at: http:// globocan.iarc.fr. Accessed September 22, 2011.
    • (2010) Lyon France International Agency for Research on Cancer
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 77952002277 scopus 로고    scopus 로고
    • Gastric cancer: A primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease
    • Shah MA, Kelsen DP. Gastric cancer: A primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease. J Natl Compr Canc Netw. 2010;8:437-447.
    • (2010) J Natl Compr Canc Netw. , vol.8 , pp. 437-447
    • Shah, M.A.1    Kelsen, D.P.2
  • 3
    • 20944437877 scopus 로고    scopus 로고
    • Survival after gastric adenocarcinoma resection: Eighteen-year experience at a single institution
    • Cunningham SC, Kamangar F, Kim MP, et al. Survival after gastric adenocarcinoma resection: eighteen-year experience at a single institution. J Gastrointest Surg. 2010;9:718-725.
    • (2010) J Gastrointest Surg. , vol.9 , pp. 718-725
    • Cunningham, S.C.1    Kamangar, F.2    Kim, M.P.3
  • 5
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J ClinOncol. 2006;24:2137-2150.
    • (2006) J ClinOncol. , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 6
    • 78650115024 scopus 로고    scopus 로고
    • Evaluation of the seventh American joint committee on cancer/international union against cancer classification of gastric adenocarcinoma in comparison with the sixth classification
    • Ahn HS, Lee HJ, Hahn S, et al. Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification. Cancer. 2010;116: 5592-5598.
    • (2010) Cancer. , vol.116 , pp. 5592-5598
    • Ahn, H.S.1    Lee, H.J.2    Hahn, S.3
  • 7
    • 22344438694 scopus 로고    scopus 로고
    • Epidemiology of gastric cancer in Japan
    • Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J. 2005;81:419-424.
    • (2005) Postgrad Med J. , vol.81 , pp. 419-424
    • Inoue, M.1    Tsugane, S.2
  • 8
    • 0027217474 scopus 로고
    • Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer
    • Murad AM, Santiago FF, Petroianu A, et al. Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer. Cancer. 1993;72:37-41.
    • (1993) Cancer. , vol.72 , pp. 37-41
    • Murad, A.M.1    Santiago, F.F.2    Petroianu, A.3
  • 9
    • 79960752090 scopus 로고    scopus 로고
    • Our experiences of best supportive care for gastric cancer patients (in Japanese with English abstract)
    • Shimoyama S, Itouji T, Enomoto H, et al. Our experiences of best supportive care for gastric cancer patients (in Japanese with English abstract). Gan To Kagaku Ryoho. 2010;37: 259-262.
    • (2010) Gan To Kagaku Ryoho. , vol.37 , pp. 259-262
    • Shimoyama, S.1    Itouji, T.2    Enomoto, H.3
  • 10
    • 79957997894 scopus 로고    scopus 로고
    • Chemotherapy in the treatment of metastatic gastric cancer: Is there a global standard
    • Kang H, Kauh JS. Chemotherapy in the treatment of metastatic gastric cancer: is there a global standard? Curr Treat Options Oncol. 2011;12:96-106.
    • (2011) Curr Treat Options Oncol. , vol.12 , pp. 96-106
    • Kang, H.1    Kauh, J.S.2
  • 13
    • 40749153540 scopus 로고    scopus 로고
    • S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial
    • Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): A phase III trial. Lancet Oncol. 2008;9:215-221.
    • (2008) Lancet Oncol. , vol.9 , pp. 215-221
    • Koizumi, W.1    Narahara, H.2    Hara, T.3
  • 14
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D, Starling N, Rao S, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008;358:36-46.
    • (2008) N Engl J Med. , vol.358 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 15
    • 63749118193 scopus 로고    scopus 로고
    • Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: A randomised phase III noninferiority trial
    • Kang YK, Kang WK, Shin DB, et al. Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: A randomised phase III noninferiority trial. Ann Oncol. 2009;20:666-673.
    • (2009) Ann Oncol. , vol.20 , pp. 666-673
    • Kang, Y.K.1    Kang, W.K.2    Shin, D.B.3
  • 16
    • 63749096474 scopus 로고    scopus 로고
    • Meta-analysis of the REAL-2 and ML17032 trials: Evaluating capecitabine-based combination chemotherapy and infused 5-fluorouracil-based combination chemotherapy for the treatment of advanced oesophago-gastric cancer
    • Okines AF, Norman AR,McCloud P, et al.Meta-analysis of the REAL-2 and ML17032 trials: evaluating capecitabine-based combination chemotherapy and infused 5-fluorouracil-based combination chemotherapy for the treatment of advanced oesophago-gastric cancer. Ann Oncol. 2009;20:1529-1534.
    • (2009) Ann Oncol , vol.20 , pp. 1529-1534
    • Okines, A.F.1    Norman, A.R.2    McCloud, P.3
  • 17
    • 33750949065 scopus 로고    scopus 로고
    • Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group
    • Van Cutsem E, Moiseyenko VM, Tjulandin S, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 Study Group. J Clin Oncol. 2006;24:4991-4997.
    • (2006) J Clin Oncol. , vol.24 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3
  • 18
    • 50849123421 scopus 로고    scopus 로고
    • HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target
    • Gravalos C, Jimeno A. HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target. Ann Oncol. 2008;19:1523-1529.
    • (2008) Ann Oncol. , vol.19 , pp. 1523-1529
    • Gravalos, C.1    Jimeno, A.2
  • 19
    • 77955479419 scopus 로고    scopus 로고
    • Combined detection of Her2/neu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer
    • Schluter B, Gerhards R, Strumberg D, et al. Combined detection of Her2/neu gene amplification and protein overexpression in effusions from patients with breast and ovarian cancer. J Cancer Res Clin Oncol. 2010;136:1389-1400.
    • (2010) J Cancer Res Clin Oncol. , vol.136 , pp. 1389-1400
    • Schluter, B.1    Gerhards, R.2    Strumberg, D.3
  • 20
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177-182.
    • (1987) Science. , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 21
    • 79953824572 scopus 로고    scopus 로고
    • HER2 Expression in gastric cancer in Peru (in Spanish with English abstract
    • Beltran GB, Yabar BA. HER2 expression in gastric cancer in Peru (in Spanish with English abstract). Rev Gastroenterol Peru. 2010;30:324-327.
    • (2010) Rev Gastroenterol Peru , vol.30 , pp. 324-327
    • Beltran, G.B.1    Yabar, B.A.2
  • 22
    • 44249092320 scopus 로고    scopus 로고
    • Assessment of a HER2 scoring system for gastric cancer: Results from a validation study
    • Hofmann M, Stoss O, Shi D, et al. Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology. 2008;52:797-805.
    • (2008) Histopathology. , vol.52 , pp. 797-805
    • Hofmann, M.1    Stoss, O.2    Shi, D.3
  • 23
    • 79958066203 scopus 로고    scopus 로고
    • Clinicopathologic characteristics of patients with stage III/IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization
    • Im SA, Kim JW, Kim JS, et al. Clinicopathologic characteristics of patients with stage III/IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization. Diagn Mol Pathol. 2011;20:94-100.
    • (2011) Diagn Mol Pathol. , vol.20 , pp. 94-100
    • Im, S.A.1    Kim, J.W.2    Kim, J.S.3
  • 24
    • 20044372721 scopus 로고    scopus 로고
    • Amplification of HER-2 in gastric carcinoma: Association with topoisomerase II alpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab
    • Tanner M, Hollmén M, Junttila TT, et al. Amplification of HER-2 in gastric carcinoma: Association with topoisomerase II alpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab. Ann Oncol. 2005;16:273-278.
    • (2005) Ann Oncol. , vol.16 , pp. 273-278
    • Tanner, M.1    Hollmén, M.2    Junttila, T.T.3
  • 26
    • 77749273477 scopus 로고    scopus 로고
    • HER2 expression in gastric cancer: Rare, heterogeneous and of no prognostic value-conclusions from 924 cases of two independent series
    • Grabsch H, Sivakumar S, Gray S, et al. HER2 expression in gastric cancer: rare, heterogeneous and of no prognostic value-conclusions from 924 cases of two independent series. Cell Oncol. 2010;32:57-65.
    • (2010) Cell Oncol. , vol.32 , pp. 57-65
    • Grabsch, H.1    Sivakumar, S.2    Gray, S.3
  • 27
    • 80055001527 scopus 로고    scopus 로고
    • Her-2/neu gene amplification and over-expression in stomach and esophageal adenocarcinoma: from pathology to treatment
    • Epub ahead of print].
    • Maresch J, Schoppmann SF, Thallinger CM, et al. Her-2/neu gene amplification and over-expression in stomach and esophageal adenocarcinoma: from pathology to treatment. Crit Rev Oncol Hematol. 2011. [Epub ahead of print].
    • (2011) Crit Rev Oncol Hematol.
    • Maresch, J.1    Schoppmann, S.F.2    Thallinger, C.M.3
  • 28
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med. 2007;357:39-51.
    • (2007) N Engl J Med. , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 29
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344:783-792.
    • (2001) N Engl J Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 30
    • 26844503270 scopus 로고    scopus 로고
    • Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
    • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005;353:1659-1672.
    • (2005) N Engl J Med. , vol.353 , pp. 1659-1672
    • Piccart-Gebhart, M.J.1    Procter, M.2    Leyland-Jones, B.3
  • 31
    • 77957300459 scopus 로고    scopus 로고
    • Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 study
    • San Antonio, TX, abstract 62.
    • Slamon D, Eiermann W, Robert N, et al. Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC-T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC-TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 study. San Antonio Breast Cancer Symposium, 2009; San Antonio, TX, abstract 62.
    • (2009) San Antonio Breast Cancer Symposium
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 32
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med. 2005;353:1673-1684.
    • (2005) N Engl J Med. , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 34
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector N.L. Blackwell KL. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer J Clin Oncol. 2009 5838-5847
    • (2009) J Clin Oncol. , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 35
    • 42449156456 scopus 로고    scopus 로고
    • Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification
    • Abstract 4613.
    • Cortés-Funes H, Rivera F, Alé s I, et al. Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification. J Clin Oncol. 2007;18S. Abstract 4613.
    • (2007) J Clin Oncol.
    • Cortés-Funes, H.1    Rivera, F.2    Alés, I.3
  • 36
    • 67650395446 scopus 로고    scopus 로고
    • Early results of a trial of trastuzumab, cisplatin, and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2
    • Istanbul, Turkey, abstract 1105P.
    • Nicholas G, Cripps C, Au H-J, et al. Early results of a trial of trastuzumab, cisplatin, and docetaxel (TCD) for the treatment of metastatic gastric cancer overexpressing HER-2. European Society for Medical Oncology Meeting, 2006
    • (2006) European Society for Medical Oncology Meeting
    • Nicholas, G.1    Cripps, C.2    Au, H.-J.3
  • 37
    • 77956262693 scopus 로고    scopus 로고
    • Rastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA) a phase 3, open-label, randomised controlled trial
    • Bang Y.J. Van Cutsem E. Feyereislova A. et al. rastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA) a phase 3, open-label, randomised controlled trial Lancet. 2010;376:687-697
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 38
    • 77954216167 scopus 로고    scopus 로고
    • Quality of life results from a phase III trial of trastuzumab plus chemotherapy in first-line HER2-positive advanced gastric and GE junction cancer
    • Orlando, FL, abstract 7.
    • Satoh T, Leon J, Lopez RI, et al. Quality of life results from a phase III trial of trastuzumab plus chemotherapy in first-line HER2-positive advanced gastric and GE junction cancer. ASCO Gastrointestinal Cancers Symposium, 2010; Orlando, FL, abstract 7.
    • (2010) ASCO Gastrointestinal Cancers Symposium
    • Satoh, T.1    Leon, J.2    Lopez, R.I.3
  • 39
    • 84872663778 scopus 로고    scopus 로고
    • Self-rated pain assessment by patients with HER2-positive advanced gastric/GEJ cancer treated with 5-FU/capecitabine and cisplatin with or without trastuzumab: Exploratory QOL analysis from the Phase III ToGA study
    • Kang Y-K, Shen L, Lichinitser M, et al. Self-rated pain assessment by patients with HER2-positive advanced gastric/GEJ cancer treated with 5-FU/capecitabine and cisplatin with or without trastuzumab: exploratory QOL analysis from the Phase III ToGA study. Gastroenterology. 2011;140:S-204.
    • (2011) Gastroenterology , vol.140
    • Kang, Y.-K.1    Shen, L.2    Lichinitser, M.3
  • 40
    • 0031972496 scopus 로고    scopus 로고
    • Interpreting the significance of changes in health-related quality-of-life scores
    • Osoba D, Rodrigues G, Myles J, et al. Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol. 1998;16:139-144.
    • (1998) J Clin Oncol. , vol.16 , pp. 139-144
    • Osoba, D.1    Rodrigues, G.2    Myles, J.3
  • 41
    • 84872673337 scopus 로고    scopus 로고
    • Quality of life results from a phase III study of trastuzumab plus chemotherapy as first-line therapy in patients with HER2-positive advanced gastric and gastro-oesophageal junction cancer
    • Ohtsu A, Wang L, Lim HY, et al. Quality of life results from a phase III study of trastuzumab plus chemotherapy as first-line therapy in patients with HER2-positive advanced gastric and gastro-oesophageal junction cancer. WCGC 2010 Barcelona, Spain, poster O-0011.
    • WCGC 2010; Barcelona, Spain, Poster O-0011
    • Ohtsu, A.1    Wang, L.2    Lim, H.Y.3
  • 44
    • 79954436118 scopus 로고    scopus 로고
    • Q-TWIST analysis of trastuzumab plus fluoropyrimidine/cisplatin (T-XP/FP) versus XP/FP alone as first-line therapy for advanced HER2-positive gastric cancer
    • Abstract 4048.
    • Chung H.C. Bang Y.-J. Van Cutsem E. et al. Q-TWIST analysis of trastuzumab plus fluoropyrimidine/cisplatin (T-XP/FP) versus XP/FP alone as first-line therapy for advanced HER2-positive gastric cancer. J Clin Oncol. 2010;28. Abstract 4048.
    • (2010) J Clin Oncol. , vol.28
    • Chung, H.C.1    Bang, Y.-J.2    Van Cutsem, E.3
  • 45
    • 79251532001 scopus 로고    scopus 로고
    • Determining the HER2 status in gastric cancer: A method comparison study of two patient cohorts
    • Orlando, FL, abstract 17.
    • Powell WC, Zielinski D, Ranger-Moore J, et al. Determining the HER2 status in gastric cancer: A method comparison study of two patient cohorts. ASCO Gastrointestinal Cancers Symposium, 2010; Orlando, FL, abstract 17.
    • (2010) ASCO Gastrointestinal Cancers Symposium
    • Powell, W.C.1    Zielinski, D.2    Ranger-Moore, J.3
  • 46
    • 84872656383 scopus 로고    scopus 로고
    • Available at:. Accessed September 22, 2011.
    • Herceptin summary of product characteristics. Available at: http://www.ema.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/ human/000278/WC500074922. pdf. Accessed September 22, 2011.
    • Herceptin Summary of Product Characteristics
  • 48
    • 84872658328 scopus 로고    scopus 로고
    • Available at:Accessed September 26
    • Herceptin prescribing information. Available at: http:// www.accessdata.fda.gov/drugsatfda-docs/label/2010/103792s5 256lbl.pdf. Accessed September 26, 2011.
    • (2011) Herceptin Prescribing Information
  • 50
    • 80054057131 scopus 로고    scopus 로고
    • Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer
    • Iqbal S, Goldman B, Fenoglio-Preiser CM, et al. Southwest Oncology Group study S0413: A phase II trial of lapatinib (GW572016) as first-line therapy in patients with advanced or metastatic gastric cancer. Ann Oncol. 2011;22:2610-2615.
    • (2011) Ann Oncol. , vol.22 , pp. 2610-2615
    • Iqbal, S.1    Goldman, B.2    Fenoglio-Preiser, C.M.3
  • 51
    • 74549210351 scopus 로고    scopus 로고
    • Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer
    • Tevaarwerk A.J. Kolesar J.M. Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer. Clin Ther. 2009;31:2332-2348.
    • (2009) Clin Ther. , vol.31 , pp. 2332-2348
    • Tevaarwerk, A.J.1    Kolesar, J.M.2
  • 52
    • 0035874981 scopus 로고    scopus 로고
    • Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
    • Molina MA, Codony-Servat J, Albanell J, et al. Trastuzumab (Herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res. 2001;61:4744-4749.
    • (2001) Cancer Res. , vol.61 , pp. 4744-4749
    • Molina, M.A.1    Codony-Servat, J.2    Albanell, J.3
  • 53
    • 49449112267 scopus 로고    scopus 로고
    • Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain
    • Gril B, Palmieri D, Bronder JL, et al. Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. J Natl Cancer Inst. 2008;100:1092-1103.
    • (2008) J Natl Cancer Inst. , vol.100 , pp. 1092-1103
    • Gril, B.1    Palmieri, D.2    Bronder, J.L.3
  • 54
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin NU, Carey LA, Younger J, et al. Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol. 2008;26:1993-1999.
    • (2008) J Clin Oncol. , vol.26 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Younger, J.3
  • 55
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355:2733-2743.
    • (2006) N Engl J Med. , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 56
    • 77955096969 scopus 로고    scopus 로고
    • Lapatinib and HER2 status: Results of a meta-analysis of randomized phase III trials in metastatic breast cancer
    • Amir E, Ocana A, Seruga B, et al. Lapatinib and HER2 status: results of a meta-analysis of randomized phase III trials in metastatic breast cancer. Cancer Treat Rev. 2010;36:410-415.
    • (2010) Cancer Treat Rev. , vol.36
    • Amir, E.1    Ocana, A.2    Seruga, B.3
  • 57
    • 77951298743 scopus 로고    scopus 로고
    • Survival benefits from lapatinib therapy in women with HER2-overexpressing breast cancer: A systematic review
    • Yip AY, Tse LA, Ong EY, et al. Survival benefits from lapatinib therapy in women with HER2-overexpressing breast cancer: A systematic review. Anticancer Drugs. 2010;21:487-493.
    • (2010) Anticancer Drugs. , vol.21 , pp. 487-493
    • Yip, A.Y.1    Tse, L.A.2    Ong, E.Y.3
  • 59
    • 84872659874 scopus 로고    scopus 로고
    • A phase III study of CapeOx +/lapatinib in HER2 positive locally advanced/metastatic upper gastrointestinal adenocarcinoma: Interim safety results
    • Berlin, Germany, poster 6.584.
    • Hecht J, Bang Y-J, Sobrero A, et al. A phase III study of CapeOx +/lapatinib in HER2 positive locally advanced/metastatic upper gastrointestinal adenocarcinoma: interim safety results. European Society for Medical Oncology Meeting 2009; Berlin, Germany, poster 6.584.
    • (2009) European Society for Medical Oncology Meeting
    • Hecht, J.1    Bang, Y.-J.2    Sobrero, A.3
  • 61
    • 79960081156 scopus 로고    scopus 로고
    • Interim safety analysis from TYTAN: A phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer
    • Abstract 4057.
    • Satoh T, Bang Y, Wang J, et al. Interim safety analysis from TYTAN a phase III Asian study of lapatinib in combination with paclitaxel as second-line therapy in gastric cancer. J ClinOncol. 2010;28. Abstract 4057.
    • (2010) J Clin Oncol. , vol.28
    • Satoh, T.1    Bang, Y.2    Wang, J.3
  • 62
    • 67651174452 scopus 로고    scopus 로고
    • Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
    • Hughes JB, Berger C, Rodland MS, et al. Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization. Mol Cancer Ther. 2009;8:1885-1892.
    • (2009) Mol Cancer Ther. , vol.18 , pp. 1885-1892
    • Hughes, J.B.1    Berger, C.2    Rodland, M.S.3
  • 63
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 2010;28:1138-1144.
    • (2010) J Clin Oncol. , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 65
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2- positive breast cancer with trastuzumab-DM1, an antibodycytotoxic drug conjugate
    • Lewis Phillips GD, Li G, Dugger DL, et al. Targeting HER2- positive breast cancer with trastuzumab-DM1, an antibodycytotoxic drug conjugate. Cancer Res. 2008;68:9280-9290.
    • (2008) Cancer Res. , vol.68 , pp. 9280-9290
    • Lewis Phillips, G.D.1    Li, G.2    Dugger, D.L.3
  • 66
    • 79959700509 scopus 로고    scopus 로고
    • Trastuzumab-DM1 (TDM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
    • Junttila TT, Li G, Parsons K, et al. Trastuzumab-DM1 (TDM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat. 2010;128:347-356.
    • (2010) Breast Cancer Res Treat. , vol.128 , pp. 347-356
    • Junttila, T.T.1    Li, G.2    Parsons, K.3
  • 67
    • 84872648176 scopus 로고    scopus 로고
    • Trastuzumab emtansine (TDM1) versus trastuzumab plus docetaxel (H+T) in previouslyuntreated HER2-positive metastatic breast cancer (MBC): Primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976)
    • Milan, Italy, abstract 5001.
    • Hurvitz S, Dirix L, Kocsis J, et al. Trastuzumab emtansine (TDM1) versus trastuzumab plus docetaxel (H+T) in previouslyuntreated HER2-positive metastatic breast cancer (MBC): primary results of a randomized, multicenter, open-label phase II study (TDM4450g/BO21976). European Society for Medical Oncology Meeting, 2010 Milan, Italy, abstract 5001.
    • (2010) European Society for Medical Oncology Meeting
    • Hurvitz, S.1    Dirix, L.2    Kocsis, J.3
  • 68
    • 84872672728 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease preliminary results of a randomized, multicenter, open-label phase 2 study
    • Milan, Italy, abstract LBA3.
    • Perez EA, Dirix L, Kocsis J, et al. Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease preliminary results of a randomized, multicenter, open-label phase 2 study. European Society for MedicalOncology Meeting, 2010; Milan, Italy, abstract LBA3.
    • (2010) European Society for MedicalOncology Meeting
    • Perez, E.A.1    Dirix, L.2    Kocsis, J.3
  • 70
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007;12:395-402.
    • (2007) Cancer Cell. , vol.12 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 71
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu Y, Zi X, Zhao Y, et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001;93:1852-1857.
    • (2001) J Natl Cancer Inst. , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3
  • 72
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HERfamily tyrosine kinase inhibitor therapy by the kinaseinactive HER3
    • Sergina NV, Rausch M, Wang D, et al. Escape from HERfamily tyrosine kinase inhibitor therapy by the kinaseinactive HER3. Nature. 2007;445:437-441.
    • (2007) Nature. , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3
  • 73
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 2004;6:117-127.
    • (2004) Cancer Cell. , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 74
    • 3543146052 scopus 로고    scopus 로고
    • Monitoring of serum Her-2/neu predicts response and progression-free survival to trastuzumab-based treatment in patients with metastatic breast cancer
    • Kostler WJ, Schwab B, Singer CF, et al. Monitoring of serum Her-2/neu predicts response and progression-free survival to trastuzumab-based treatment in patients with metastatic breast cancer. Clin Cancer Res. 2004;10:1618-1624.
    • (2004) Clin Cancer Res. , vol.10 , pp. 1618-1624
    • Kostler, W.J.1    Schwab, B.2    Singer, C.F.3
  • 75
    • 0026071364 scopus 로고
    • The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3
    • Zabrecky JR, Lam T, McKenzie SJ, et al. The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. J Biol Chem. 1991;266: 1716-1720.
    • (1991) J Biol Chem. , vol.266 , pp. 1716-1720
    • Zabrecky, J.R.1    Lam, T.2    McKenzie, S.J.3
  • 76
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptinresistant, MUC4-expressing breast cancer cell line
    • Nagy P, Friedlander E, Tanner M, et al. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptinresistant, MUC4-expressing breast cancer cell line. Cancer Res. 2005;65:473-482.
    • (2005) Cancer Res. , vol.65 , pp. 473-482
    • Nagy, P.1    Friedlander, E.2    Tanner, M.3
  • 77
    • 0037142184 scopus 로고    scopus 로고
    • Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance
    • Price-Schiavi SA, Jepson S, Li P, et al. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int J Cancer. 2002;99:783-791.
    • (2002) Int J Cancer. , vol.99 , pp. 783-791
    • Price-Schiavi, S.A.1    Jepson, S.2    Li, P.3
  • 78
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neupositive metastatic breast cancer
    • Musolino A, Naldi N, Bortesi B, et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neupositive metastatic breast cancer. J Clin Oncol. 2008;26: 1789-1796.
    • (2008) J Clin Oncol. , vol.26 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3
  • 79
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28:1124-1130.
    • (2010) J Clin Oncol. , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 80
    • 79952258750 scopus 로고    scopus 로고
    • First results of the NeoALTTO Trial (BIG 01-06/EGF 106903): A phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer
    • San Antonio, TX, abstract S3-3.
    • Baselga J, Bradbury I, Eidtmann H, et al. First results of the NeoALTTO Trial (BIG 01-06/EGF 106903): A phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer. San Antonio Breast Cancer Symposium, 2010
    • (2010) San Antonio Breast Cancer Symposium
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 81
    • 79952274439 scopus 로고    scopus 로고
    • Neoadjuvant pertuzumab (P) and trastuzumab (H) p antitumor and safety analysis of a randomized phase II study (-NeoSphere-)
    • San Antonio, TX,abstract S3-2.
    • Gianni L, Pienkowski T, Im Y-H, et al. Neoadjuvant pertuzumab (P) and trastuzumab (H) antitumor and safety analysis of a randomized phase II study (-NeoSphere-). San Antonio Breast CancerSymposium, 2010; San Antonio, TX,abstract S3-2.
    • (2010) San Antonio Breast CancerSymposium
    • Gianni, L.1    Pienkowski, T.2    Im, Y.-H.3
  • 82
    • 80053526705 scopus 로고    scopus 로고
    • Adjuvant capecitabine and oxaliplatin for gastric cancer: Results of the phase IIICLASSIC trial
    • abstract LBA4002.
    • Bang Y, Kim YW, Yang H, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer: results of the phase IIICLASSIC trial. J Clin Oncol. 2011;29. abstract LBA4002.
    • (2011) J Clin Oncol. , vol.29
    • Bang, Y.1    Kim, Y.W.2    Yang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.