Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) in the majority of the alopecia areata patients: Is it a primitive and pathogenic perturbation of hypothalamic-pituitary-adrenal axis

International Journal of Trichology

Volumn 3, Issue 1, 2011, Pages 43-44

  D'Ovidio, Roberto ^a   D'Ovidio, Francesco D ^b  

^a Day Hospital SCamillo   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84865490736     PISSN: 09747753     EISSN: 09749241     Source Type: Journal    
DOI: 10.4103/0974-7753.82130     Document Type: Letter

References (11)

1. Eskandari F, Webster JI, Sternberg EM. Neural immune pathways and their connection to inflammatory diseases. Arthritis Res Ther 2003;5:251-65.
2. Forsblad-d'Elia H, Carlsten H, Labrie F, Konttinen YT, Ohlsson C. Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores theconcentrations. J Clin Endocrinol Metab 2009;94:2044-51.
3. Solerte SB, Precerutti S, Gazzaruso C, Locatelli E, Zamboni M, Schifino N, et al. Defect of a subpopulation of natural killer immune cells in Graves' disease and Hashimoto's thyroiditis: normalizing effect of dehydroepiandrosterone sulfate. Eur JEndocrinol 2005;152:703-12.
4. Kasumagić-Halilović E. Thyroid autoimmunity in patients with alopecia areata. Acta Dermatovenerol Croat 2008;16:123-5.
5. Gönül M, Gül U, Cakmak S, Kilinç C, Kilinç S. Prolactine levels in the patients with alopecia areata. J Eur Acad Dermatol Venereol 2009;23:1343-4.
6. Vinokurov IN. Pathogenesis of severe forms of alopecia areata. Sov Med 1972;35:127-31.
7. Montagnani A, Orlandi F, Patrone P, Serra D, De Camillis M, Ferrari MG. Adrenal steroid-genetic activity in subjects with alopecia totalis or subtotalis diffuse alopecia and alopecia areata. Ital Gen Rev Dermatol 1978;15:13-5.
8. Hazeldine J, Arlt W, Lord JM. Dehydroepiandrosterone as a regulator of immune cell function. J Steroid Biochem Mol Biol 2010;120:127-36.
9. Kaufman G, d'Ovidio R, Kaldawy A, Assy B, Ullmann Y, Etzioni A, et al. An unexpected twist in alopecia areata pathogenesis: are NK cells protectiveand CD49b+ T cells pathogenic? Exp Dermatol 2010;19:e347-9
10. Jeckel CM, Lopes RP, Berleze MC, Luz C, Feix L, Argimon II, et al. Neuroendocrine and immunological correlates of chronic stress in 'strictlyhealthy' populations. Neuroimmunomodulation 2010;17:9-18.
11. Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Baliva G, Melchi CF, et al. Psychosomatic factors in first-onset alopecia areata. Psychosomatics 2003;44:374-81.