Lymph node yield at radical cystectomy predicts mortality in node-negative and not node-positive patients

Urology

Volumn 80, Issue 3, 2012, Pages 632-640

  Morgan, Todd M ^a   Barocas, Daniel A ^a   Penson, David F ^a,b   Chang, Sam S ^a   Ni, Shenghua ^a   Clark, Peter E ^a   Smith Jr , Joseph A ^a   Cookson, Michael S ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b Education and Clinical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BLADDER CARCINOMA; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER REGISTRY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; COHORT ANALYSIS; COMORBIDITY; CONFOUNDING VARIABLE; CYSTECTOMY; DENSITY; DISEASE SPECIFIC SURVIVAL; FEMALE; HUMAN; LYMPH NODE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MEDICARE; MORTALITY; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; URINARY DIVERSION; UROTHELIAL BLADDER CARCINOMA;

EID: 84865486061     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2012.03.070     Document Type: Article

References (30)

1. P.P. Dangle, M.C. Gong, R.R. Bahnson How do commonly performed lymphadenectomy templates influence bladder cancer nodal stage? J Urol 183 2010 499 503
2. N.B. Dhar, E.A. Klein, A.M. Reuther Outcome after radical cystectomy with limited or extended pelvic lymph node dissection J Urol 179 2008 873 878 [Discussion:878]
3. J. Leissner, M.A. Ghoneim, H. Abol-Enein Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study J Urol 171 2004 139 144
4. B.R. Konety, S.A. Joslyn, M.A. O'Donnell Extent of pelvic lymphadenectomy and its impact on outcome in patients diagnosed with bladder cancer: analysis of data from the Surveillance, Epidemiology and End Results Program data base J Urol 169 2003 946 950
5. J.P. Stein, J. Cai, S. Groshen Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density J Urol 170 2003 35 41
6. H.W. Herr, B.H. Bochner, G. Dalbagni Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer J Urol 167 2002 1295 1298
7. J. Leissner, R. Hohenfellner, J.W. Throff Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis BJU Int 85 2000 817 823
8. M. May, E. Herrmann, C. Bolenz Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy Eur Urol 59 2011 712 718
9. A.L. Poulsen, T. Horn, K. Steven Radical cystectomy: extending the limits of pelvic lymph node dissection improves survival for patients with bladder cancer confined to the bladder wall J Urol 160 6 Pt 1 1998 2015 2019 [Discussion:2020]
10. J.L. Wright, D.W. Lin, M.P. Porter The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy Cancer 112 2008 2401 2408
11. G.S. Kulkarni, A. Finelli, G. Lockwood Effect of healthcare provider characteristics on nodal yield at radical cystectomy Urology 72 2008 128 132
12. C.A. Goossens-Laan, G.A. Gooiker, W. van Gijn A systematic review and meta-analysis of the relationship between hospital/surgeon volume and outcome for radical cystectomy: an update for the ongoing debate Eur Urol 59 2011 775 783
13. H.W. Herr, J.R. Faulkner, H.B. Grossman Surgical factors influence bladder cancer outcomes: a cooperative group report J Clin Oncol 22 2004 2781 2789
14. J.L. Warren, C.N. Klabunde, D. Schrag Overview of the SEER-Medicare data: content, research applications, and generalizability to the United States elderly population Med Care 40 8 Suppl 2002 IV-3 IV-18
15. C.N. Klabunde, A.L. Potosky, J.M. Legler Development of a comorbidity index using physician claims data J Clin Epidemiol 53 2000 1258 1267
16. H.W. Herr Superiority of ratio based lymph node staging for bladder cancer J Urol 169 2003 943 945
17. J.L. Warren, L.C. Harlan, A. Fahey Utility of the SEER-Medicare data to identify chemotherapy use Med Care 40 8 Suppl 2002 IV-55 IV-61
18. D.R. Urbach, P.C. Austin Conventional models overestimate the statistical significance of volume-outcome associations, compared with multilevel models J Clin Epidemiol 58 2005 391 400
19. J.D. Birkmeyer Understanding surgeon performance and improving patient outcomes J Clin Oncol 22 2004 2765 2766
20. A. Fleischmann, G.N. Thalmann, R. Markwalder Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factor J Clin Oncol 23 2005 2358 2365
21. B.K. Hollenbeck, Z. Ye, S.L. Wong Hospital lymph node counts and survival after radical cystectomy Cancer 112 2008 806 812
22. C. Wiesner, A. Salzer, C. Thomas Cancer-specific survival after radical cystectomy and standardized extended lymphadenectomy for node-positive bladder cancer: prediction by lymph node positivity and density BJU Int 104 2009 331 335
23. S.M. Gilbert Separating surgical quality from causalitygaining perspective in the debate on lymph node count and extent of lymphadenectomy Cancer 112 2008 2331 2333
24. T.M. Koppie, A.J. Vickers, K. Vora Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed? Cancer 107 2006 2368 2374
25. M. May, E. Herrmann, C. Bolenz Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy Ann Surg Oncol 18 2011 2018 2025
26. A.R. Feinstein, D.M. Sosin, C.K. Wells The Will Rogers phenomenon Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer N Engl J Med 312 1985 1604 1608
27. H.L. Copp, J.L. Chin, M. Conaway Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma Cancer 107 2006 60 66
28. J. Gordetsky, E. Scosyrev, H. Rashid Identifying additional lymph nodes in radical cystectomy lymphadenectomy specimens Mod Pathol 25 2012 140 144
29. Davies JD, Simons CM, Ruhotina N, et al. Pelvic lymph node dissection for bladder cancer: an autopsy study. AUA Annual Meeting May 14-19, 2011. Abstract 1895.
30. C. Nez-Mora, J.M. Garca Mediero, P.M. Cabrera-Castillo Feasibility of lymphadenectomy in laparoscopic radical cystectomy Urology 76 2010 759 763