Safety evaluation of cephalosporins based on utilization and adverse drug events: Analysis of two databases in China

Expert Opinion on Drug Safety

Volumn 11, Issue 5, 2012, Pages 689-697

  Ren, Xiuhua ^a   Liu, Dong ^a   Ding, Nan ^a   Huang, Kun ^b   Xiong, Yongshan ^c   Du, Guang ^a   Zeng, Fandian ^a,d  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Food and Drug Administration   (China)

^c Wuhan Food and Drug Administration   (China)

^d Section of Pharmacoepidemiology of Pharmaceutical Association in Wuhan   (China)

Author keywords

adverse drug event; cephalosporins; defined daily dose; pharmacovigilance; safety evaluation

Indexed keywords

CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFAMANDOLE NAFATE; CEFAZOLIN; CEFDINIR; CEFDITOREN; CEFETAMET PIVOXIL; CEFIXIME; CEFMENOXIME; CEFMETAZOLE; CEFMINOX; CEFODIZIME; CEFONICID; CEFOTAXIME; CEFOTIAM; CEFOXITIN; CEFPIRAMIDE; CEFPODOXIME; CEFPROZIL; CEFRADINE; CEFTAZIDIME; CEFTERAM PIVOXIL; CEFTIZOXIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; SULPERAZON; UNINDEXED DRUG;

ACUTE KIDNEY FAILURE; ADOLESCENT; ADULT; ADVERSE DRUG REACTION; AGE DISTRIBUTION; AGED; ANAPHYLAXIS; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; CHINA; CLINICAL FEATURE; DRUG ABUSE; DRUG COST; DRUG HYPERSENSITIVITY; DRUG INFORMATION; DRUG MISUSE; DRUG SAFETY; DRUG SCREENING; DRUG UTILIZATION; FEMALE; GASTROINTESTINAL TOXICITY; HEPATOBILIARY DISEASE; HUMAN; INFANT; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; NEWBORN; PERIPHERAL NEUROPATHY; PRESCHOOL CHILD; RESPIRATORY TRACT DISEASE; RETROSPECTIVE STUDY; REVIEW; SCHOOL CHILD; SEX DIFFERENCE; SKIN TOXICITY; URINARY TRACT DISEASE;

ADOLESCENT; ADULT; ADVERSE DRUG REACTION REPORTING SYSTEMS; AGED; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; CHILD; CHINA; DATABASES, FACTUAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; DRUG UTILIZATION REVIEW; FEMALE; HOSPITALS, URBAN; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; PHARMACOVIGILANCE; PHYSICIAN'S PRACTICE PATTERNS; RETROSPECTIVE STUDIES;

EID: 84865469519     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2012.699037     Document Type: Review

References (27)

1. Yao L, Zhang R, Mao S, et al. Use of antibiotics in Shanghai second and third level hospitals during the period of 2007 - 2008. Eval Analyst Drug Hosp China 2010;10:971-3; in Chinese
2. Li C, Xu L, Jiao H. Application analysis of antibiotics in our hospital in 2009. Chin J Drug Appl Monit 2010;7:293-4; in Chinese
3. Zhao ZH, Jing WL, Wang XY, et al. Relationship of antibacterials use and bacterial drug resistance in hospitalized patients. Chin J Nosocomiol 2010;20:3017-19; in Chinese
4. Shi ZH, Xiao ZP, Tan LM, et al. Analysis of 612 cases of antibiotics-induced ADR in our hospital. Chin Pharm 2010;21:3615-17; in Chinese
5. Camille S, Johanna G. Principles of selection and use of antimicrobial agents. Semin Pediatr Infect Dis 1999;10:3-13
6. Welte T, Pletz MW. Antimicrobial treatment of nosocomial meticillin-resistant Staphylococcus aureus (MRSA) pneumonia: current and future options. Int J Antimicrob Agents 2010;36:391-400
7. Trontell AE. How the US Food and Drug Administration defines and detects adverse drug events. Curr Ther Res Clin Exp 2001;62:641-9 (Pubitemid 33016178)
8. Montastruc JL, Sommet A, Lacroix I, et al. Pharmacovigilance for evaluating adverse drug reactions: value, organization, and methods. Joint Bone Spine 2006;73:629-32 (Pubitemid 44932244)
9. Hohl CM, Nosyk B, Kuramoto L, et al. Outcomes of emergency department patients presenting with adverse drug events. Ann Emerg Med 2011;58:270-9
10. Johansson SGO, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832-6 (Pubitemid 38608590)
11. Doherty MJ. Algorithms for assessing the probability of an adverse drug reaction. Respir Med 2009;2:63-7
12. Robert C, Owens Jr. Antimicrobial stewardship: concepts and strategies in the 21st century. Diagn Microbilo Infect Dis 2008;61:110-28 (Pubitemid 351509755)
13. Jin K, Wang S, Huang Z, et al. Clostridium difficile infections in China. J Biomed Res 2010;24:411-16
14. Paterson DL, Ko WC, Von Gottberg A, et al. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extendedspectrum beta-lactamases: implications for the clinical microbiology laboratory. J Clin Microbiol 2001;39:2206-12 (Pubitemid 32531482)
15. Courpon-Claudinon A, Lefort A, Panhard X, et al. Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France: prevalence, molecular epidemiology and clinical features. Clin Microbiol Infect 2011;17:557-65
16. With KD, Bergner J, Buhner R, et al. Antibiotic use in German university hospitals 1998-2000 (Project INTERUNI-II). Int J Antimicrob Agents 2004;24:15-20 (Pubitemid 39140537)
17. Pluss-Suard C, Pannatier A, Kronenberg A, et al. Hospital antibiotic consumption in Switzerland: comparison of a multicultural country with Europe. J Hosp Infect 2011;79:166-71
18. Owens RC, Ambrose PG. Antimicrobial stewardship and the role of pharmacokinetics-pharmacodynamics in the modern antibiotic era. Diagn Micr Infect Dis 2007;57:S77-83 (Pubitemid 46349493)
19. Isturiz RE. Optimizing antimicrobial prescribing. Int J Antimicrob Agents 2010;36:S19-22
20. Currie J, Lin W, Zhang W. Patient knowledge and antibiotic abuse: evidence from an audit study in China. J Health Econ 2011;30:933-49
21. Buke AC, Ermertcan S, Hosgor-Limoncu M, et al. Rational antibiotic use and academic staff. Int J Antimicrob Agents 2003;21:63-6 (Pubitemid 36043976)
22. Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Micr Infect Dis 1995;22:89-96
23. Mitropoulos IF, Rotschafer JC, Rodvold KA. Adverse events associated with the use of oral cephalosporins/ cephems. Diagn Micr Infect Dis 2007;57:S67-76 (Pubitemid 46349490)
24. Singh J, Arrieta AC. New cephalosporins. Semin Pediatr Infect Dis 1999;10:14-22 (Pubitemid 29133242)
25. Burt R. Meyers. Cefaclor revisited. Clin Ther 2000;22:154-66
26. Antunez C, Blanca-Lopez N, Torres MJ, et al. Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins. J Allergy Clin Immun 2006;117:404-10 (Pubitemid 43190154)
27. Campagna JD, Bond MC, Schabelman E, et al. The use of cephalosporins in penicillin-allergic patients: a literature review. J Emerg Med 2011;35:1-9