Moringa oleifera Lam.: Protease activity against blood coagulation cascade

Pharmacognosy Research

Volumn 4, Issue 1, 2012, Pages 44-49

  Satish, A ^a   Sairam, Sudha ^a   Ahmed, Faiyaz ^a   Urooj, Asna ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

Caseinolytic; fibrinogenolytic; fibrinolytic; Moringa oleifera; procoagulant

Indexed keywords

ANTICOAGULANT AGENT; CASEIN; FIBRINOGEN; MORINGA OLEIFERA EXTRACT; PROTEINASE; WOUND HEALING PROMOTING AGENT;

ARTICLE; BLOOD CLOTTING; COLORIMETRY; ELECTROPHORESIS; ENZYME ACTIVITY; FIBRIN CLOT; FIBRINOLYSIS; HUMAN; HYDROLYSIS; MORINGA OLEIFERA; NONHUMAN; PLANT LEAF; PLANT ROOT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; WOUND HEALING; ZYMOGRAPHY;

EID: 84865463093     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.91034     Document Type: Article

References (22)

1. Konno K, Hirayama C, Masatoshi N, Tateishi K, Tamura Y, Hattori M, et al. Papain protects papaya trees from herbivorous insects: Role of cysteine proteases in latex. Plant J 2004;37:370-8.
2. Rajesh R, Shivaprasad HV, Gowda RC, Nataraju A, Dhananjaya BL, Vishwanath BS. Comparative study on plant latex proteases and their involvement in hemostasis: A special emphasis on clot inducing and dissolving properties. Planta Med 2007;73:1061-7.
3. Richter G, Hans PS, Friedrich D, Peter L. Activation and inactivation of human factor X by proteases derived from Ficus carica. Br J Haematol 2002;119:1042-51.
4. Shivaprasad HV, Riyaz M, Kumar VR, Dharmappa KK, Tarannum S, Siddesha JM. Cysteine proteases from the Asclepiadaceae plants latex exhibited thrombin and plasmin like activities. J Thromb Thrombolysis 2008;28:304-8.
5. Rajesh R, Gowda CD, Nataraju A, Dhananjaya BL. Purification and characterization of a 34-kDa, heat stable glycoprotein from Synadenium grantii latex: Action on human fibrinogen and fibrin clot. Biochimie 2006;88:1313-22.
6. Mehta AB. Management of coagulopathy in patients with liver disease undergoing surgical intervention. Indian J Gastroenterol 2006;25:19-21.
7. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: A food plant with multiple medicinal uses. Phytother Res 2007;21:1725.
8. Goyal BR, Agrawal BB, Goyal RK. Phyto-Pharmacology of Moringa oleifera Lam: An overview. Nat Prod Rad 2007;6:34753.
9. Khan M, Patil PA, Shobha JC. Influence of Bryophyllum pinnatum (Lam.) leaf extract on wound healing in albino rats. J Nat Rem 2004;4:41-6.
10. Hukkeri VI, Nagathan CV, Karadi RV, Patil BS. Antipyretic and wound healing activities of Moringa oleifera Lam. in rats. Indian J Pharm Sci 2006;68:124-6.
11. Satyavati GV, Gupta AK Medicinal plants of India. Indian Council of Medical Research. 1987;2:272-8.
12. Selvakumar D, Natarajan P. Hepato-Protective activity of Moringa oleifera Lam. leaves in carbon tetrachloride induced hepato-toxicity in albino rats. Pharmacogn Mag 2008;4:97-8.
13. Laemmli UK. Cleavage of structural proteins during the assembly of head of bacteriophage T4. Nature 1970;227:680-5.
14. Murata J, Satake M, Suzuki T. Studies on snake venom. XII. Distribution of proteinase activities among Japanese and Formosan snake venoms. J Biochem 1963;53:431-43.
15. Kim SH, Choi NS, Lee WY. Fibrin zymography: A direct analysis of fibrinolytic enzymes on gels. Anal Biochem 1998;263:115-6.
16. Condrea E, Yang CC, Rosenberg P. Anticoagulant activity and plasma phophatidylserine hydrolysis by snake venom phospholipase A2. Thromb Haemost 1983;49:151-7.
17. Ouyang C, Teng CM. Fibrinogenolytic enzymes of Trimeresurus mucrosquamatus Venom. Biochim Biophys Acta 1976;420: 298-308.
18. Joo HS, Park GC, Cho WR, Tak E, Paik SR, Chang CS. Purification and characterization of a prothrombin-activating protease from Nephila ciavata. Toxicon 2002;40:289-96.
19. Rajesh R, Gowda CD, Nataraju A, Dhananjaya BL, Kemparaju K, Vishwanath BS. Procoagulant activity of Calotropis gigantea latex associated with fibrin (ogen) olytic activity. Toxicon 2005;46:84-92.
20. Gene A, Roy G, Rojas JM, Gutierrez S, Cerdas L. Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom. Toxicon 1989;27: 841-8.
21. Komori Y, Sugihara H, Tu AT Specificity of haemorrhagic proteinase from Crotalus atrox (Western diamond back rattle snake) venom. Biochim Biophys Acta 1985;829:127-30.
22. Lijnen HR. Matrix metalloprotenases and their cellular fibrinolytic activity. Biochemistry (Mosc) 2002;67:92-8.