Comparative effects of proportional assist and variable pressure support ventilation on lung function and damage in experimental lung injury

Critical Care Medicine

Volumn 40, Issue 9, 2012, Pages 2654-2661

  Spieth, Peter M ^a   Güldner, Andreas ^a   Beda, Alessandro ^a,b   Carvalho, Nadja ^a   Nowack, Thomas ^a   Krause, Anke ^a   Rentzsch, Ines ^a   Suchantke, Sabina ^a   Thal, Serge C ^c   Engelhard, Kristin ^c   Kasper, Michael ^d   Koch, Thea ^a   Pelosi, Paolo ^e   De Abreu, Marcelo Gama ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e UNIVERSITY OF GENOA   (Italy)

Author keywords

acute lung injury; mechanical ventilation; pressure support ventilation; proportional assist ventilation; variable ventilation; ventilator induced lung injury

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; ASSISTED VENTILATION; BLOOD OXYGENATION; BREATHING; BREATHING PATTERN; COMPARATIVE STUDY; CONTROLLED STUDY; CONVENTIONAL PRESSURE SUPPORT VENTILATION; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; HISTOPATHOLOGY; IMMUNE RESPONSE; LUNG FUNCTION; LUNG INJURY; LUNG LAVAGE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROPORTIONAL ASSIST VENTILATION; RESPIRATORY TRACT PARAMETERS; TIDAL VOLUME; VARIABLE PRESSURE SUPPORT VENTILATION;

ACUTE LUNG INJURY; ANIMALS; DISEASE MODELS, ANIMAL; HEMODYNAMICS; INFLAMMATION MEDIATORS; INTERACTIVE VENTILATORY SUPPORT; POSITIVE-PRESSURE RESPIRATION; PULMONARY GAS EXCHANGE; RANDOM ALLOCATION; RESPIRATORY FUNCTION TESTS; RISK ASSESSMENT; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SWINE; TREATMENT OUTCOME; VENTILATOR-INDUCED LUNG INJURY;

EID: 84865462567     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182592021     Document Type: Article

References (31)

1. Putensen C, Zech S, Wrigge H, et al: Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 2001; 164:43-49
2. Esteban A, Ferguson ND, Meade MO, et al: VENTILA Group: Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 2008; 177:170-177
3. Varelmann D, Wrigge H, Zinserling J, et al: Proportional assist versus pressure support ventilation in patients with acute respiratory failure: Cardiorespiratory responses to artificially increased ventilatory demand. Crit Care Med 2005; 33:1968-1975
4. Gama de Abreu M, Spieth PM, Pelosi P, et al: Noisy pressure support ventilation: A pilot study on a new assisted ventilation mode in experimental lung injury. Crit Care Med 2008; 36:818-827
5. Arold SP, Mora R, Lutchen KR, et al: Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am J Respir Crit Care Med 2002; 165:366-371
6. Spieth PM, Carvalho AR, Güldner A, et al: Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure support. Crit Care Med 2011; 39:746-755
7. Carvalho AR, Spieth PM, Güldner A, et al: Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury. J Appl Physiol 2011; 110:1083-1092
8. Mutch WA, Harms S, Ruth Graham M, et al: Biologically variable or naturally noisy mechanical ventilation recruits atelectatic lung. Am J Respir Crit Care Med 2000; 162:319-323
9. Younes M: Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Dis 1992; 145:114-120
10. Younes M, Puddy A, Roberts D, et al: Proportional assist ventilation. Results of an initial clinical trial. Am Rev Respir Dis 1992; 145:121-129
11. Alexopoulou C, Kondili E, Vakouti E, et al: Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med 2007; 33:1139-1147
12. Xirouchaki N, Kondili E, Vaporidi K, et al: Proportional assist ventilation with load-adjustable gain factors in critically ill patients: Comparison with pressure support. Intensive Care Med 2008; 34:2026-2034
13. Costa R, Spinazzola G, Cipriani F, et al: A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV). Intensive Care Med 2011; 37:1494-1500
14. de Abreu MG, Quelhas AD, Spieth P, et al: Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury. Anesthesiology 2006; 104:278-289
15. Lachmann B, Robertson B, Vogel J: In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand 1980; 24:231-236
16. Spieth PM, Carvalho AR, Güldner A, et al: Effects of different levels of pressure support variability in experimental lung injury. Anesthesiology 2009; 110:342-350
17. Peng CK, Mietus JE, Liu Y, et al: Quantifying fractal dynamics of human respiration: Age and gender effects. Ann Biomed Eng 2002; 30:683-692
18. Meier T, Leibecke T, Eckmann C, et al: Electrical impedance tomography: Changes in distribution of pulmonary ventilation during laparoscopic surgery in a porcine model. Langenbecks Arch Surg 2006; 391:383-389
19. Spieth PM, Knels L, Kasper M, et al: Effects of vaporized perfluorohexane and partial liquid ventilation on regional distribution of alveolar damage in experimental lung injury. Intensive Care Med 2007; 33:308-314
20. Goldberger AL: Giles f. Filley lecture. Complex systems. Proc Am Thorac Soc 2006; 3:467-471
21. Kuratomi Y, Okazaki N, Ishihara T, et al: Variability of breath-by-breath tidal volume and its characteristics in normal and diseased subjects. Ventilatory monitoring with electrical impedance pneumography. Jpn J Med 1985; 24:141-149
22. Tobin MJ, Mador MJ, Guenther SM, et al: Variability of resting respiratory drive and timing in healthy subjects. J Appl Physiol 1988; 65:309-317
23. Suki B, Alencar AM, Sujeer MK, et al: Life-support system benefits from noise. Nature 1998; 393:127-128
24. Froehlich KF, Graham MR, Buchman TG, et al: Physiological noise versus white noise to drive a variable ventilator in a porcine model of lung injury. Can J Anaesth 2008; 55:577-586
25. Wysocki M, Meshaka P, Richard JC, et al: Proportional-assist ventilation compared with pressure-support ventilation during exercise in volunteers with external thoracic restriction. Crit Care Med 2004; 32:409-414
26. Passam F, Hoing S, Prinianakis G, et al: Effect of different levels of pressure support and proportional assist ventilation on breathing pattern, work of breathing and gas exchange in mechanically ventilated hypercapnic COPD patients with acute respiratory failure. Respiration 2003; 70:355-361
27. Wysocki M, Richard JC, Meshaka P: Noninvasive proportional assist ventilation compared with noninvasive pressure support ventilation in hypercapnic acute respiratory failure. Crit Care Med 2002; 30:323-329
28. Marantz S, Patrick W, Webster K, et al: Response of ventilator-dependent patients to different levels of proportional assist. J Appl Physiol 1996; 80:397-403
29. Pelosi P, Goldner M, McKibben A, et al: Recruitment and derecruitment during acute respiratory failure: An experimental study. Am J Respir Crit Care Med 2001; 164:122-130
30. Dolinay T, Kaminski N, Felgendreher M, et al: Gene expression profiling of target genes in ventilator-induced lung injury. Physiol Genomics 2006; 26:68-75
31. Spieth PM, Carvalho AR, Pelosi P, et al: Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. Am J Respir Crit Care Med 2009; 179:684-693