Altered IL-10 and TNF-α production in peripheral blood mononuclear cells of systemic lupus erythematosus patients after Toll-like receptor 2, 4, or 9 activation

Clinical and Experimental Medicine

Volumn 12, Issue 3, 2012, Pages 153-158

  Tsao, Jeng Ting ^a   Hsieh, Song Chou ^b   Chiang, Bor Luen ^c   Yu, Chia Li ^b   Lin, Shih Chang ^a,d,e  

^a CATHAY GENERAL HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d Cathay Medical Research Institute   (Taiwan)

^e FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

IL 10; Systemic lupus erythematosus (SLE); TNF ; Toll like receptor (TLR)

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL ISOLATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; CASE-CONTROL STUDIES; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; LIPOPROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MALE; PRIMARY CELL CULTURE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84865454316     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-011-0161-6     Document Type: Article

References (20)

1. H Kumar T Kawai S Akira 2009 Toll-like receptors and innate immunity Biochem Biophys Res Commun 388 4 621 625 19686699 10.1016/j.bbrc.2009.08.062 1:CAS:528:DC%2BD1MXhtFajsb7O
2. S Manicassamy B Pulendran 2009 Modulation of adaptive immunity with Toll-like receptors Semin Immunol 21 4 185 193 19502082 10.1016/j.smim.2009.05. 005 1:CAS:528:DC%2BD1MXhtFajtrfM
3. W McCormack AE Parker LA O'Neill 2009 Toll-like receptors and NOD-like receptors in rheumatic diseases Arthritis Res Ther 11 5 243 19835640 10.1186/ar2729
4. A Iwasaki R Medzhitov 2010 Regulation of adaptive immunity by the innate immune system Science 327 5963 291 295 20075244 10.1126/science.1183021 1:CAS:528:DC%2BC3cXktlWkuw%3D%3D
5. AM Avalos L Busconi A Marshak-Rothstein 2010 Regulation of autoreactive B cell responses to endogenous TLR ligands Autoimmunity 43 1 76 83 20014959 10.3109/08916930903374618 1:CAS:528:DC%2BC3cXovVCgug%3D%3D
6. R Lafyatis A Marshak-Rothstein 2007 Toll-like receptors and innate immune responses in systemic lupus erythematosus Arthritis Res Ther 9 6 222 18086320 10.1186/ar2321
7. E Bouza JG Moya P Muñoz 2001 Infections in systemic lupus erythematosus and rheumatoid arthritis Infect Dis Clin North Am 15 2 335 361 11447699 10.1016/S0891-5520(05)70149-5 1:STN:280:DC%2BD38%2FhvFOnug%3D%3D
8. M Juárez R Misischia GS Alarcón 2003 Infections in systemic connective tissue diseases: systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis Rheum Dis Clin North Am 29 1 163 184 12635506 10.1016/S0889-857X(02)00100-X
9. DY Yap KN Lai 2010 Cytokines and their roles in the pathogenesis of systemic lupus erythematosus: from basics to recent advances J Biomed Biotechnol 2010 365083 20467470 10.1155/2010/365083
10. L Llorente Y Richaud-Patin 2003 The role of interleukin-10 in systemic lupus erythematosus J Autoimmun 20 4 287 289 12791314 10.1016/S0896-8411(03) 00043-X 1:CAS:528:DC%2BD3sXkt1Glur8%3D
11. AK Palucka J-P Blanck L Bennett V Pascual J Banchereau 2005 Cross-regulation of TNF and IFN-α in autoimmune diseases Proc Natl Acad Sci USA 102 9 3372 3377 15728381 10.1073/pnas.0408506102 1:CAS:528: DC%2BD2MXitl2lur0%3D
12. S Morimoto Y Tokano S Nakano T Watanabe Y Tamayama A Mitsuo, et al. 2009 Chemoattractant mechanism of Th1 cells in class III and IV lupus nephritis Autoimmunity 42 2 143 149 19021013 10.1080/08916930802438790 1:CAS:528:DC%2BD1MXpsVyltA%3D%3D
13. EM Tan AS Cohen JF Fries AT Masi DJ McShane NF Rothfield, et al. 1982 The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 25 11 1271 1277 7138600 10.1002/art.1780251101 1:STN:280:DyaL3s%2FkvVCmtA%3D%3D
14. C Bombardier DD Gladman MB Urowitz D Caron CH Chang 1992 Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE Arthritis Rheum 35 6 630 640 1599520 10.1002/art.1780350606 1:STN:280:DyaK383oslWrtg%3D%3D
15. JM Roda R Parihar WE Carson 3rd 2005 CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells J Immunol 175 3 1619 1627 16034101 1:CAS:528:DC%2BD2MXmtlWjtLs%3D
16. Ozato K, Tsujimura H, Tamura T (2002) Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques Suppl:66-68, 70, 72 passim
17. K Takeda T Kaisho S Akira 2003 Toll-like receptors Annu Rev Immunol 21 335 376 12524386 10.1146/annurev.immunol.21.120601.141126 1:CAS:528: DC%2BD3sXjtF2isrg%3D
18. K Migita T Miyashita Y Maeda M Nakamura H Yatsuhashi H Kimura, et al. 2007 Toll-like receptor expression in lupus peripheral blood mononuclear cells J Rheumatol 34 3 493 500 17295441 1:CAS:528:DC%2BD2sXktVCju7o%3D
19. A Komatsuda H Wakui K Iwamoto M Ozawa M Togashi R Masai, et al. 2008 Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus Clin Exp Immunol 152 3 482 487 18373699 10.1111/j.1365-2249.2008.03646.x 1:CAS:528:DC%2BD1cXnvVOitb8%3D
20. A Marshak-Rothstein 2006 Toll-like receptors in systemic autoimmune disease Nat Rev Immunol 6 11 823 835 17063184 10.1038/nri1957 1:CAS:528:DC%2BD28XhtFWns7fP