Pharmacokinetic and toxicological evaluation of multi-functional thiol-6-fluoro-6-deoxy-d-glucose gold nanoparticles in vivo

Nanotechnology

Volumn 23, Issue 37, 2012, Pages

  Roa, Wilson ^a   Xiong, Yeping ^a   Chen, Jie ^a,b   Yang, Xiaoyan ^a   Song, Kun ^c   Yang, Xiaohong ^a   Kong, Beihua ^c   Wilson, John ^d   Xing, James Z ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c SHANDONG UNIVERSITY   (China)

^d CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIODISTRIBUTIONS; CANCER CELLS; CANCER DIAGNOSIS; CELLULAR UPTAKE; GOLD NANOPARTICLES; IMAGE-GUIDED RADIATION THERAPY; IN-VITRO; IN-VIVO; INTRAVENOUS INJECTIONS; MULTI-FUNCTIONAL; MURINE MODEL; PEGYLATION; PHARMACOKINETIC DATA; PHARMACOKINETIC PROPERTIES; POSITRON EMISSION TOMOGRAPHY SCANNING; RADIATION EFFICIENCY; THIOL FUNCTIONAL GROUPS; TIME WINDOWS; TOXICOLOGICAL EVALUATION;

CELL DEATH; FUNCTIONAL GROUPS; GLUCOSE; METAL NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; RADIOTHERAPY;

PHARMACOKINETICS;

6 DEOXY 6 FLUOROGLUCOSE; 6-DEOXY-6-FLUOROGLUCOSE; ANTINEOPLASTIC AGENT; DEOXYGLUCOSE; DRUG DERIVATIVE; GOLD; NANOPARTICLE; RADIOSENSITIZING AGENT; THIOL DERIVATIVE;

ADENOCARCINOMA; ANIMAL; ARTICLE; BREAST; BREAST TUMOR; CHEMISTRY; DRUG EFFECT; FEMALE; MOUSE; PATHOLOGY; RADIATION EXPOSURE; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DEOXYGLUCOSE; FEMALE; GOLD; MICE; NANOPARTICLES; RADIATION-SENSITIZING AGENTS; SULFHYDRYL COMPOUNDS;

EID: 84865438923     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/23/37/375101     Document Type: Article

References (26)

1. Chen Y H et al 2007 Methotrexate conjugated to gold nanoparticles inhibits tumour growth in a syngeneic lung tumour model Mol. Pharm. 4 713-22 (Pubitemid 350004271)
2. Dreaden E C et al 2009 Tamoxifen-poly(ethylene glycol)-thiol gold nanoparticle conjugates: enhanced potency and selective delivery for breast cancer treatment Bioconjug. Chem. 20 2247-53
3. Brown S D et al 2010 Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin J. Am. Chem. Soc. 132 4678-84
4. Curley S A et al 2008 Noninvasive radiofrequency field-induced hyperthermic cytotoxicity in human cancer cells using cetuximab-targeted gold nanoparticles J. Exp. Ther. Oncol. 7 313-26
5. Terentyuk G S et al 2009 Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy J. Biomed. Opt. 14 021016
6. Cherukuri P and Curley S A 2010 Use of nanoparticles for targeted, noninvasive thermal destruction of malignant cells Methods Mol. Biol. 624 359-73
7. Hainfeld J F, Dilmanian F A, Slatkin D N and Smilowitz H M 2008 Radiotherapy enhancement with gold nanoparticles J. Pharm. Pharmacol. 60 977-85
8. Castillo M H et al 1988 Effects of radiotherapy on mandibular reconstruction plates Am. J. Surg. 156 61-3
9. Niroomand-rad A, Razavi A, Thobejane S and Harter K W 1996 Radiation dose perturbation at tissue-titanium dental interfaces in head and neck cancer patients Int. J. Radiat. Oncol. Biol. Phys. 34 475-80 (Pubitemid 26031595)
10. Li X A, Chu J C, Chen W and Zusag T 1999 Dose enhancement by a thin foil of high-Z material: a Monte Carlo study Med. Phys. 26 1245-51 (Pubitemid 29334790)
11. Regulla D F, Hieber L B and Seidenbusch M 1998 Physical and biological interface dose effects in tissue due to x-ray-induced release of secondary radiation from metallic gold surfaces Radiat. Res. 150 92-100 (Pubitemid 28285629)
12. Kong T et al 2008 Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles Small 4 1537-43
13. Zhang X et al 2008 Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles Clin. Invest. Med. 31 E160-7
14. Geng F et al 2011 Thiol-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer Nanotechnology 22 285101
15. Roa W et al 2009 Gold-nanoparticles sensitize radiotherapy of prostate cancer cells by regulation of cell cycle Nanotechnology 20 375101
16. Connor E E et al 2005 Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity Small 1 325-7 (Pubitemid 43951781)
17. Chen J et al 2010 Gold nanocages as photothermal transducers for cancer treatment Small 7 811-7
18. Aydogan B et al 2010 Deoxyglucose-labeled gold nanoparticles as x-ray computed tomography contrast agents for cancer imaging Mol. Imaging Biol. 12 463-7
19. Bustamante E and Pedersen P L 1977 High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase Proc. Natl Acad. Sci. USA 74 3735 (Pubitemid 8189957)
20. Landau B R et al 2007 6-Fluoro-6-deoxy-d-glucose as a tracer of glucose transpor Am. J. Physiol. Endocrinol. Metab. 293 E237-45 (Pubitemid 47105937)
21. Perrault S D and Chan W C W 2009 Synthesis and surface modification of highly monodispersed, spherical gold nanoparticles of 50-200 nm J. Am. Chem. Soc. 131 17042
22. Kim D, Park S, Lee J H, Jeong Y Y and Jon S 2007 Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging J. Am. Chem. Soc. 129 7661-5 (Pubitemid 46981930)
23. Wang C H et al 2008 Optimizing the size and surface properties of polyethylene glycol (PEG)-gold nanoparticles by intense x-ray irradiation J. Phys. D: Appl. Phys. 41 195301
24. Oyewumi M O, Yokel R A, Jay M, Coakley T and Mumper R J 2004 Comparison of cell uptake, biodistribution and tumour retention of folate-coated and PEG-coated Gadolinium nanoparticles in tumour-bearing mice J. Control. Release 95 613-26 (Pubitemid 38340510)
25. Owens D E III and Peppas N A 2006 Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int. J. Pharm. 307 93-102 (Pubitemid 41773257)
26. Bergen J M et al 2006 Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery Macromol. Biosci. 6 506-16 (Pubitemid 44105947)