The significance of duodenal mucosal atrophy in patients with common variable immunodeficiency: A clinical and histopathologic study

American Journal of Clinical Pathology

Volumn 138, Issue 2, 2012, Pages 185-189

  Biagi, Federico ^a   Bianchi, Paola I ^a   Zilli, Alessandra ^a   Marchese, Alessandra ^a   Luinetti, Ombretta ^b   Lougaris, Vassilios ^c   Plebani, Alessandro ^c   Villanacci, Vincenzo ^c   Corazza, Gino R ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Celliac disease; Common variable immunodeficiency; Endomysial antibodies; Gluten; Gluten free diet; Hypogammaglobulinemia

Indexed keywords

ENDOMYSIUM ANTIBODY; GLIADIN; HEMAGGLUTININ; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY;

ADULT; ARTICLE; CELIAC DISEASE; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL EVALUATION; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; DIARRHEA; DUODENUM BIOPSY; DUODENUM MUCOSA; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGUS; FECES ANALYSIS; FEMALE; GASTROSCOPY; GLUTEN FREE DIET; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; HLA TYPING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN DEFICIENCY; INTESTINE INJURY; INTESTINE VILLUS ATROPHY; JEJUNUM; LYMPHOCYTE COUNT; MALE; PLASMA CELL; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; STEATORRHEA; WEIGHT REDUCTION;

ADULT; ATROPHY; BIOPSY; CELIAC DISEASE; COMMON VARIABLE IMMUNODEFICIENCY; DUODENUM; FEMALE; GRAFT VS HOST DISEASE; HUMANS; INTESTINAL MUCOSA; MALE; NEUTROPHILS; PLASMA CELLS;

EID: 84865425398     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPEIILH2C0WFYE     Document Type: Article

References (20)

1. Park MA, Li JT, Hagan JB, et al. Common variable immunodeficiency: a new look at an old disease. Lancet 2008;372:489-502.
2. Kalha I, Sellin JH. Common variable immunodeficiency and the gastrointestinal tract. Curr Gastroenterol Rep. 2004;6:377-383. (Pubitemid 39480909)
3. Luzi G, Zullo A, Iebba F, et al. Duodenal pathology and clinical-immunological implications in common variable immunodeficiency patients. Am J Gastroenterol. 2003;98:118-121. (Pubitemid 36135179)
4. Agarwal S, Mayer L. Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes. J Allergy Clin Immunol. 2009;124:658-664.
5. Daniels JA, Lederman HM, Maitra A, et al. Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. Am J Surg Pathol. 2007;31:1800-1812. (Pubitemid 350175807)
6. Mannon PJ, Fuss IJ, Dill S, et al. Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology. 2006;131:748-756. (Pubitemid 44307070)
7. Bästlein C, Burlefinger R, Holzberg E, et al. Common variable immunodeficiency syndrome and nodular lymphoid hyperplasia in the small intestine. Endoscopy. 1988;20:272-275.
8. Washington K, Stenzel TT, Buckley RH, et al. Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. Am J Surg Pathol. 1996;20:1240-1252. (Pubitemid 26336849)
9. Khodadad A, Aghamohammadi A, Parvaneh N, et al. Gastrointestinal manifestations in patients with common variable immunodeficiency. Dig Dis Sci 2007;52:2977-2983. (Pubitemid 47512541)
10. Teahon K, Webster AD, Price AB, et al. Studies on the enteropathy associated with primary hypogammaglobulinaemia. Gut 1994;35:1244-1249. (Pubitemid 24277338)
11. Martucci S, Biagi F, Di Sabatino A, et al. Coeliac disease. Dig Liver Dis. 2002;34(suppl 2)S150-S153.
12. Heneghan MA, Stevens FM, Cryan EM, et al. Celiac sprue and immunodeficiency states: a 25-year review. J Clin Gastroenterol 1997;25:421-425. (Pubitemid 27528122)
13. Webster AD, Slavin G, Shiner M, et al. Coeliac disease with severe hypogammaglobulinaemia. Gut. 1981;22:153-157.
14. Lai Ping So A, Mayer L. Gastrointestinal manifestations of primary immunodeficiency disorders. Semin Gastrointest Dis. 1997;8:22-32. (Pubitemid 27045982)
15. Herbst EW, Armbruster M, Rump JA, et al. Intestinal B cell defects in common variable immunodeficiency. Clin Exp Immunol. 1994;95:215-221. (Pubitemid 24207129)
16. Malamut G, Verkarre V, Suarez F, et al. The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease. Am J Gastroenterol. 2010;105:2262-2275.
17. Wood P. Primary antibody deficiency syndromes. Ann Clin Biochem. 2009;46:99-108.
18. Biagi F, Pezzimenti D, Campanella J, et al. Endomysial and tissue transglutaminase antibodies in coeliac sera: a comparison not influenced by previous serological testing. Scand J Gastroenterol. 2001;36:955-958. (Pubitemid 32681459)
19. Sollid LM, Lie BA. Celiac disease genetics: current concepts and practical applications. Clin Gastroenterol Hepatol. 2005;3:843-851. (Pubitemid 41222309)
20. Cataldo F, Lio D, Marino V, et al. IgG(1) antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency - Working Groups on Celiac Disease of SIGEP and Club del Tenue. Gut. 2000;47:366-369.