Serum microRNA biomarkers for drug-induced liver injury

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 3, 2012, Pages 291-293

  Starkey Lewis, P J ^a   Merz, M ^b   Couttet, P ^b   Grenet, O ^b   Dear, J ^c,d   Antoine, D J ^a   Goldring, C ^a   Park, B K ^a   Moggs, J G ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d NPIS Edinburgh   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; LIVER ENZYME; MICRORNA; MICRORNA 122; MICRORNA 192; PARACETAMOL;

ARTICLE; CLINICAL PRACTICE; DISEASE COURSE; DRUG EFFICACY; DRUG SAFETY; HUMAN; LIVER FAILURE; LIVER NECROSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RNA ANALYSIS; RNA ISOLATION; TOXIC HEPATITIS;

ANIMALS; BIOLOGICAL MARKERS; DRUG-INDUCED LIVER INJURY; HUMANS; LIVER; MICE; MICRORNAS; PHARMACEUTICAL PREPARATIONS;

EID: 84865404634     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.101     Document Type: Article

References (6)

1. Wang, K. et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. USA 106, 4402-4407 (2009).
2. Zhang, Y. et al. Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin. Chem. 56, 1830-1838 (2010).
3. Starkey Lewis, P.J. et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 54, 1767-1776 (2011).
4. Arroyo, J.D. et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl. Acad. Sci. USA 108, 5003-5008 (2011).
5. Starkey-Lewis, P.J., Dear, J., Platt, V., Moggs, J., Goldring, C.E. & Park, B.K. Reply to Qiet al. Hepatology 55, 1642-1643 (2012).
6. Harrill, A.H. et al. The efects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers. Clin. Pharmacol. Ther. 92, 214-220 (2012).