메뉴 건너뛰기




Volumn 224, Issue 1, 2012, Pages 177-186

Targeted profiling of atherogenic phospholipids in human plasma and lipoproteins of hyperlipidemic patients using MALDI-QIT-TOF-MS/MS

Author keywords

Atherosclerosis; Clinical lipidomics; Familial hyperlipidemia; LC ESI (SRM) MS MS; Lipid biomarkers; Lyso phosphatidylcholine (LPC); MALDI (QIT) TOF MS( MS); Oxidized phospholipids (OxPLs); Sphingomyelin (SM)

Indexed keywords

BIOLOGICAL MARKER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN; PHOSPHOLIPID;

EID: 84865400140     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.06.010     Document Type: Article
Times cited : (79)

References (46)
  • 1
    • 0014976138 scopus 로고
    • Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study
    • Kannel W.B., Castelli W.P., Gordon T., McNamara P.M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med 1971, 74:1-12.
    • (1971) Ann Intern Med , vol.74 , pp. 1-12
    • Kannel, W.B.1    Castelli, W.P.2    Gordon, T.3    McNamara, P.M.4
  • 2
    • 0016841975 scopus 로고
    • Letter: high-density lipoprotein and atherosclerosis
    • Miller N.E., Miller G.J. Letter: high-density lipoprotein and atherosclerosis. Lancet 1975, 1:1033.
    • (1975) Lancet , vol.1 , pp. 1033
    • Miller, N.E.1    Miller, G.J.2
  • 3
    • 77954509575 scopus 로고    scopus 로고
    • Atherosclerosis, diabetes and lipoproteins
    • Tomkin G.H. Atherosclerosis, diabetes and lipoproteins. Expert Rev Cardiovasc Ther 2010, 8:1015-1029.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1015-1029
    • Tomkin, G.H.1
  • 4
    • 77049094889 scopus 로고    scopus 로고
    • Heterozygous familial hypercholesterolaemia in childhood: cardiovascular risk prevention
    • van der G.A., Kastelein J.J., Wiegman A. Heterozygous familial hypercholesterolaemia in childhood: cardiovascular risk prevention. J Inherit Metab Dis 2009, 32:699-705.
    • (2009) J Inherit Metab Dis , vol.32 , pp. 699-705
    • van der, G.A.1    Kastelein, J.J.2    Wiegman, A.3
  • 5
    • 0032482329 scopus 로고    scopus 로고
    • Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa heart study
    • Berenson G.S., Srinivasan S.R., Bao W., Newman W.P., Tracy R.E., Wattigney W.A. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa heart study. N Engl J Med 1998, 338:1650-1656.
    • (1998) N Engl J Med , vol.338 , pp. 1650-1656
    • Berenson, G.S.1    Srinivasan, S.R.2    Bao, W.3    Newman, W.P.4    Tracy, R.E.5    Wattigney, W.A.6
  • 6
    • 78650030824 scopus 로고    scopus 로고
    • Sudden death in a 4-year-old boy: a near-complete occlusion of the coronary artery caused by an aggressive low-density lipoprotein receptor mutation (W556R) in homozygous familial hypercholesterolemia
    • Widhalm K., Binder C.B., Kreissl A., et al. Sudden death in a 4-year-old boy: a near-complete occlusion of the coronary artery caused by an aggressive low-density lipoprotein receptor mutation (W556R) in homozygous familial hypercholesterolemia. J Pediatr 2011, 158:167.
    • (2011) J Pediatr , vol.158 , pp. 167
    • Widhalm, K.1    Binder, C.B.2    Kreissl, A.3
  • 7
    • 18244373708 scopus 로고    scopus 로고
    • Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target
    • Zalewski A., Macphee C. Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target. Arterioscler Thromb Vasc Biol 2005, 25:923-931.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 923-931
    • Zalewski, A.1    Macphee, C.2
  • 8
  • 9
    • 0028128943 scopus 로고
    • The oxidation hypothesis of atherosclerosis
    • Witztum J.L. The oxidation hypothesis of atherosclerosis. Lancet 1994, 344:793-795.
    • (1994) Lancet , vol.344 , pp. 793-795
    • Witztum, J.L.1
  • 10
    • 0029591967 scopus 로고
    • Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolemia
    • Napoli C., Postiglione A., Triggiani M., et al. Oxidative structural modifications of low density lipoprotein in homozygous familial hypercholesterolemia. Atherosclerosis 1995, 118:259-273.
    • (1995) Atherosclerosis , vol.118 , pp. 259-273
    • Napoli, C.1    Postiglione, A.2    Triggiani, M.3
  • 11
    • 21444447949 scopus 로고    scopus 로고
    • Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease
    • Tsimikas S., Brilakis E.S., Miller E.R., et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 2005, 353:46-57.
    • (2005) N Engl J Med , vol.353 , pp. 46-57
    • Tsimikas, S.1    Brilakis, E.S.2    Miller, E.R.3
  • 12
    • 0032810502 scopus 로고    scopus 로고
    • Nonoxidative modifications of lipoproteins in atherogenesis
    • Tabas I. Nonoxidative modifications of lipoproteins in atherogenesis. Annu Rev Nutr 1999, 19:123-139.
    • (1999) Annu Rev Nutr , vol.19 , pp. 123-139
    • Tabas, I.1
  • 13
    • 33646902155 scopus 로고    scopus 로고
    • Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study
    • Tsimikas S., Kiechl S., Willeit J., et al. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol 2006, 47:2219-2228.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2219-2228
    • Tsimikas, S.1    Kiechl, S.2    Willeit, J.3
  • 14
    • 37549004312 scopus 로고    scopus 로고
    • Role of lysophosphatidylcholine (LPC) in atherosclerosis
    • Matsumoto T., Kobayashi T., Kamata K. Role of lysophosphatidylcholine (LPC) in atherosclerosis. Curr Med Chem. 2007, 14:3209-3220.
    • (2007) Curr Med Chem. , vol.14 , pp. 3209-3220
    • Matsumoto, T.1    Kobayashi, T.2    Kamata, K.3
  • 15
    • 33646124981 scopus 로고    scopus 로고
    • Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease
    • Schlitt A., Blankenberg S., Yan D., et al. Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease. Nutr Metabol (Lond) 2006, 3:5.
    • (2006) Nutr Metabol (Lond) , vol.3 , pp. 5
    • Schlitt, A.1    Blankenberg, S.2    Yan, D.3
  • 16
    • 0028080105 scopus 로고
    • Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids
    • Han X., Gross R.W. Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc Natl Acad Sci U S A 1994, 91:10635-10639.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10635-10639
    • Han, X.1    Gross, R.W.2
  • 17
    • 5444275263 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research
    • Schiller J., Suss R., Arnhold J., et al. Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research. Prog Lipid Res 2004, 43:449-488.
    • (2004) Prog Lipid Res , vol.43 , pp. 449-488
    • Schiller, J.1    Suss, R.2    Arnhold, J.3
  • 18
    • 51249095381 scopus 로고    scopus 로고
    • Recent developments in tandem mass spectrometry for lipidomic analysis
    • Zehethofer N., Pinto D.M. Recent developments in tandem mass spectrometry for lipidomic analysis. Anal Chim Acta 2008, 627:62-70.
    • (2008) Anal Chim Acta , vol.627 , pp. 62-70
    • Zehethofer, N.1    Pinto, D.M.2
  • 19
    • 34247401793 scopus 로고    scopus 로고
    • Analysis of lipids using 2,4,6-trihydroxyacetophenone as a matrix for MALDI mass spectrometry
    • Stubiger G., Belgacem O. Analysis of lipids using 2,4,6-trihydroxyacetophenone as a matrix for MALDI mass spectrometry. Anal Chem 2007, 79:3206-3213.
    • (2007) Anal Chem , vol.79 , pp. 3206-3213
    • Stubiger, G.1    Belgacem, O.2
  • 20
    • 69249102909 scopus 로고    scopus 로고
    • Analysis of human plasma lipids and soybean lecithin by means of high-performance thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry
    • Stubiger G., Pittenauer E., Belgacem O., Rehulka P., Widhalm K., Allmaier G. Analysis of human plasma lipids and soybean lecithin by means of high-performance thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 2009, 23:2711-2723.
    • (2009) Rapid Commun Mass Spectrom , vol.23 , pp. 2711-2723
    • Stubiger, G.1    Pittenauer, E.2    Belgacem, O.3    Rehulka, P.4    Widhalm, K.5    Allmaier, G.6
  • 21
    • 77954194249 scopus 로고    scopus 로고
    • Analysis of oxidized phospholipids by MALDI mass spectrometry using 6-aza-2-thiothymine together with matrix additives and disposable target surfaces
    • Stubiger G., Belgacem O., Rehulka P., Bicker W., Binder B.R., Bochkov V. Analysis of oxidized phospholipids by MALDI mass spectrometry using 6-aza-2-thiothymine together with matrix additives and disposable target surfaces. Anal Chem 2010, 82:5502-5510.
    • (2010) Anal Chem , vol.82 , pp. 5502-5510
    • Stubiger, G.1    Belgacem, O.2    Rehulka, P.3    Bicker, W.4    Binder, B.R.5    Bochkov, V.6
  • 22
    • 80051475466 scopus 로고    scopus 로고
    • Influence of HSA and IgG on LDL oxidation studied by size-exclusion chromatography and phospholipid profiling using MALDI tandem-mass spectrometry
    • Stubiger G., Sobal G., Widhalm K., Belgacem O., Pock K. Influence of HSA and IgG on LDL oxidation studied by size-exclusion chromatography and phospholipid profiling using MALDI tandem-mass spectrometry. Chem Phys Lipids 2011, 164:563-572.
    • (2011) Chem Phys Lipids , vol.164 , pp. 563-572
    • Stubiger, G.1    Sobal, G.2    Widhalm, K.3    Belgacem, O.4    Pock, K.5
  • 23
    • 0037709384 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionization- quadrupole ion trap-time of flight mass spectrometry sequencing resolves structures of unidentified peptides obtained by in-gel tryptic digestion of haptoglobin derivatives from human plasma proteomes
    • Koy C., Mikkat S., Raptakis E., et al. Matrix-assisted laser desorption/ionization- quadrupole ion trap-time of flight mass spectrometry sequencing resolves structures of unidentified peptides obtained by in-gel tryptic digestion of haptoglobin derivatives from human plasma proteomes. Proteomics 2003, 3:851-858.
    • (2003) Proteomics , vol.3 , pp. 851-858
    • Koy, C.1    Mikkat, S.2    Raptakis, E.3
  • 24
    • 0032143306 scopus 로고    scopus 로고
    • Compensatory arterial enlargement is a common pathobiologic response in early atherosclerosis
    • Labropoulos N., Zarge J., Mansour M.A., Kang S.S., Baker W.H. Compensatory arterial enlargement is a common pathobiologic response in early atherosclerosis. Am J Surg 1998, 176:140-143.
    • (1998) Am J Surg , vol.176 , pp. 140-143
    • Labropoulos, N.1    Zarge, J.2    Mansour, M.A.3    Kang, S.S.4    Baker, W.H.5
  • 25
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 26
    • 77950604843 scopus 로고    scopus 로고
    • An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples
    • Zhao Z., Xu Y. An extremely simple method for extraction of lysophospholipids and phospholipids from blood samples. J Lipid Res 2010, 51:652-659.
    • (2010) J Lipid Res , vol.51 , pp. 652-659
    • Zhao, Z.1    Xu, Y.2
  • 27
    • 33847206104 scopus 로고    scopus 로고
    • Isolation of esterified fatty acids bound to serum albumin purified from human plasma and characterised by MALDI mass spectrometry
    • Belgacem O., Stubiger G., Allmaier G., Buchacher A., Pock K. Isolation of esterified fatty acids bound to serum albumin purified from human plasma and characterised by MALDI mass spectrometry. Biologicals 2007, 35:43-49.
    • (2007) Biologicals , vol.35 , pp. 43-49
    • Belgacem, O.1    Stubiger, G.2    Allmaier, G.3    Buchacher, A.4    Pock, K.5
  • 28
    • 78650659753 scopus 로고    scopus 로고
    • Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation
    • Oskolkova O.V., Afonyushkin T., Preinerstorfer B., et al. Oxidized phospholipids are more potent antagonists of lipopolysaccharide than inducers of inflammation. J Immunol 2010, 185:7706-7712.
    • (2010) J Immunol , vol.185 , pp. 7706-7712
    • Oskolkova, O.V.1    Afonyushkin, T.2    Preinerstorfer, B.3
  • 29
    • 0033912094 scopus 로고    scopus 로고
    • Increase in fragmented phosphatidylcholine in blood plasma by oxidative stress
    • Frey B., Haupt R., Alms S., et al. Increase in fragmented phosphatidylcholine in blood plasma by oxidative stress. J Lipid Res 2000, 41:1145-1153.
    • (2000) J Lipid Res , vol.41 , pp. 1145-1153
    • Frey, B.1    Haupt, R.2    Alms, S.3
  • 30
    • 34948882706 scopus 로고    scopus 로고
    • Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
    • Podrez E.A., Byzova T.V., Febbraio M., et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 2007, 13:1086-1095.
    • (2007) Nat Med , vol.13 , pp. 1086-1095
    • Podrez, E.A.1    Byzova, T.V.2    Febbraio, M.3
  • 31
    • 0024320626 scopus 로고
    • Molecular species of glycerophospholipids and sphingomyelins of human plasma: comparison to red blood cells
    • Myher J.J., Kuksis A., Pind S. Molecular species of glycerophospholipids and sphingomyelins of human plasma: comparison to red blood cells. Lipids 1989, 24:408-418.
    • (1989) Lipids , vol.24 , pp. 408-418
    • Myher, J.J.1    Kuksis, A.2    Pind, S.3
  • 32
    • 64349124701 scopus 로고    scopus 로고
    • Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
    • Wiesner P., Leidl K., Boettcher A., Schmitz G., Liebisch G. Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 2009, 50:574-585.
    • (2009) J Lipid Res , vol.50 , pp. 574-585
    • Wiesner, P.1    Leidl, K.2    Boettcher, A.3    Schmitz, G.4    Liebisch, G.5
  • 33
    • 80051469082 scopus 로고    scopus 로고
    • Novel approach for detection of dietary based changes of plasma lipids and molecular lipoprotein modifications
    • Stubiger G., Sobal G., Montgomery H., Widhalm K., Pock K., Belgacem O. Novel approach for detection of dietary based changes of plasma lipids and molecular lipoprotein modifications. Atheroscler Suppl 2008, 9:157.
    • (2008) Atheroscler Suppl , vol.9 , pp. 157
    • Stubiger, G.1    Sobal, G.2    Montgomery, H.3    Widhalm, K.4    Pock, K.5    Belgacem, O.6
  • 34
    • 34548485062 scopus 로고    scopus 로고
    • The role of hypertriglyceridemia in atherosclerosis
    • Le N.A., Walter M.F. The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 2007, 9:110-115.
    • (2007) Curr Atheroscler Rep , vol.9 , pp. 110-115
    • Le, N.A.1    Walter, M.F.2
  • 35
    • 0032520147 scopus 로고    scopus 로고
    • Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase
    • Jeong T., Schissel S.L., Tabas I., Pownall H.J., Tall A.R., Jiang X. Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest 1998, 101:905-912.
    • (1998) J Clin Invest , vol.101 , pp. 905-912
    • Jeong, T.1    Schissel, S.L.2    Tabas, I.3    Pownall, H.J.4    Tall, A.R.5    Jiang, X.6
  • 36
    • 0029762320 scopus 로고    scopus 로고
    • Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins
    • Schissel S.L., Tweedie-Hardman J., Rapp J.H., Graham G., Williams K.J., Tabas I. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Invest 1996, 98:1455-1464.
    • (1996) J Clin Invest , vol.98 , pp. 1455-1464
    • Schissel, S.L.1    Tweedie-Hardman, J.2    Rapp, J.H.3    Graham, G.4    Williams, K.J.5    Tabas, I.6
  • 37
    • 30644466209 scopus 로고    scopus 로고
    • Membrane-lipid therapy: a new approach in molecular medicine
    • Escriba P.V. Membrane-lipid therapy: a new approach in molecular medicine. Trends Mol Med 2006, 12:34-43.
    • (2006) Trends Mol Med , vol.12 , pp. 34-43
    • Escriba, P.V.1
  • 38
    • 55049115059 scopus 로고    scopus 로고
    • Mass spectrometry analysis of oxidized phospholipids
    • Domingues M.R., Reis A., Domingues P. Mass spectrometry analysis of oxidized phospholipids. Chem Phys Lipids 2008, 156:1-12.
    • (2008) Chem Phys Lipids , vol.156 , pp. 1-12
    • Domingues, M.R.1    Reis, A.2    Domingues, P.3
  • 39
    • 0031689740 scopus 로고    scopus 로고
    • Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group
    • Kern H., Volk T., Knauer-Schiefer S., et al. Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group. Biochim Biophys Acta 1998, 1394:33-42.
    • (1998) Biochim Biophys Acta , vol.1394 , pp. 33-42
    • Kern, H.1    Volk, T.2    Knauer-Schiefer, S.3
  • 40
    • 0034737582 scopus 로고    scopus 로고
    • The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein
    • Boullier A., Gillotte K.L., Horkko S., et al. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem 2000, 275:9163-9169.
    • (2000) J Biol Chem , vol.275 , pp. 9163-9169
    • Boullier, A.1    Gillotte, K.L.2    Horkko, S.3
  • 41
    • 0032420956 scopus 로고    scopus 로고
    • Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation
    • Karakatsani A.I., Liapikos T.A., Troganis A.N., Tsoukatos D.C. Involvement of phospholipids in apolipoprotein B modification during low density lipoprotein oxidation. Lipids 1998, 33:1159-1162.
    • (1998) Lipids , vol.33 , pp. 1159-1162
    • Karakatsani, A.I.1    Liapikos, T.A.2    Troganis, A.N.3    Tsoukatos, D.C.4
  • 42
    • 0037896283 scopus 로고    scopus 로고
    • Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    • Horkko S., Bird D.A., Miller E., et al. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest 1999, 103:117-128.
    • (1999) J Clin Invest , vol.103 , pp. 117-128
    • Horkko, S.1    Bird, D.A.2    Miller, E.3
  • 43
    • 9144233520 scopus 로고    scopus 로고
    • Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a)
    • Edelstein C., Pfaffinger D., Hinman J., et al. Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). J Biol Chem 2003, 278:52841-52847.
    • (2003) J Biol Chem , vol.278 , pp. 52841-52847
    • Edelstein, C.1    Pfaffinger, D.2    Hinman, J.3
  • 44
    • 0029299438 scopus 로고
    • The response-to-retention hypothesis of early atherogenesis
    • Williams K.J., Tabas I. The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol 1995, 15:551-561.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 551-561
    • Williams, K.J.1    Tabas, I.2
  • 45
    • 0026493679 scopus 로고
    • High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors
    • Bowry V.W., Stanley K.K., Stocker R. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proc Natl Acad Sci U S A 1992, 89:10316-10320.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10316-10320
    • Bowry, V.W.1    Stanley, K.K.2    Stocker, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.