Serum levels of N-acetyl-aspartate in migraine and tension-type headache

Journal of Headache and Pain

Volumn 13, Issue 5, 2012, Pages 389-394

  De Tommaso, Marina ^a   Ceci, Edmondo ^b   Pica, Carmela ^a   Trojano, Maria ^a   Delussi, Marianna ^a   Franco, Giovanni ^a   Livrea, Paolo ^a   Ruggieri, Maddalena ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Department of Animal Production   (Italy)

Author keywords

Migraine; Serum N acetyl aspartate; Tension type headache

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; CHRONIC TENSION HEADACHE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EPISODIC TENSION HEADACHE; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MIGRAINE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; PRIORITY JOURNAL; TENSION HEADACHE; TRANSFORMED MIGRAINE;

ADULT; ANALYSIS OF VARIANCE; ASPARTIC ACID; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; LINEAR MODELS; MALE; MASS SPECTROMETRY; MIDDLE AGED; MIGRAINE DISORDERS; TENSION-TYPE HEADACHE; YOUNG ADULT;

EID: 84865394456     PISSN: 11292369     EISSN: 11292377     Source Type: Journal    
DOI: 10.1007/s10194-012-0448-3     Document Type: Article

References (32)

1. Montagna P (2008) Migraine: a genetic disease? Neurol Sci 29(Suppl 1):S47-S51 (Pubitemid 351836963)
2. Sarchielli P, Tarducci R, Presciutti O, Gobbi G, Pelliccioli GP, Stipa G, Alberti A, Capocchi G (2005) Functional 1H-MRS findings in migraine patients with and without aura assessed interictally. Neuroimage 15:1025-1031 (Pubitemid 40164504)
3. Goldstein FB (1969) The enzymatic synthesis of N-acetyl-Laspartic acid by subcellular preparations of rat brain. J Biol Chem 244:4257-4260
4. Urenjak J, Williams SR, Gadian DG, Noble M (1992) Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 59:55-61
5. Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB (1996) Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. NeuroReport 7:1397-1400 (Pubitemid 26281000)
6. Clark JB (1998) N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci 20:271-276
7. Gu T, Ma XX, Xu YH, Xiu JJ, Li CF (2008) Metabolite concentration ratios in thalami of patients with migraine and trigeminal neuralgia measured with 1H-MRS. Neurol Res 30(3): 229-233 (Pubitemid 351769413)
8. Gustin SM, Peck CC, Wilcox SL, Nash PG, Murray GM, Henderson LA (2011) Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. J Neurosci 20:5956-5964
9. Stevens H, Jakobs C, de Jager AEJ, Cunningham RT, Korf J (1999) Neuron-specific enolase and N-acetyl-aspartate as potential peripheral markers of ischaemic stroke. Eur J Clin Invest 29:6-11 (Pubitemid 29084242)
10. Jasperse B, Jakobs C, Eikelenboom MJ, Dijkstra CD, Uitdehaag BM, Barkhof F, Polman CH, Teunissen CE (2007) N-Acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry. J Neurol 254:631-637 (Pubitemid 46781977)
11. Teunissen CE, Iacobaeu E, Khademi M et al (2009) Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis. Neurology 72:1322-1329
12. Ruggieri M, Tortorella C, Ceci E, Paolicelli D, Solfrizzi V, Di Bitonto G, Pica C, Mastrapasqua M, Livrea P, Trojano M (2011) Age-related changes of serum N-acetyl-aspartate in healthy controls. Age Ageing 40(3):391-395
13. Ruggieri M, Serpino C, Ceci E, Sciruicchio V, Franco G, Pica C, Trojano M, Livrea P, de Tommaso M (2011) Serum levels of Nacetylaspartate in Huntington's disease: preliminary results. Mov Disord. doi:10.1002/mds.23974
14. Simone IL, Ruggieri M, Tortelli R, Ceci E, D'Errico E, Leo A, Zoccolella S, Mastrapasqua M, Capozzo R, Livrea P, Logroscino G (2011) Serum N-acetylaspartate level in amyotrophic lateral sclerosis. Arch Neurol 68(10):1308-1312
15. Tortorella C, Ruggieri M, Di Monte E, Ceci E, Iaffaldano P, Direnzo V, Mastrapasqua M, Frigeri A, Amato MP, Hakiki B, Ghezzi A, Lugaresi A, De Luca G, Patti F, D'Amico E, Sola P, Simone AM, Svelto M, Livrea P, Trojano M (2011) Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis optica. J Neurol Neurosurg Psychiatry 82(12):1355-1359
16. Headache Classification Committee (2004) The international classification of headache disorders II. Cephalalgia 24:24-136
17. de Tommaso M, Federici A, Serpino C, Vecchio E, Franco G, Sardaro M, Delussi M, Livrea P (2011) Clinical features of headache patients with fibromyalgia comorbidity. J Headache Pain 12(6):629-638
18. Stewart WF, Lipton RB, Kolodner K, Liberman J, Sawyer J (1999) Reliability of the migraine disability assessment score in a population-based sample of headache sufferers. Cephalalgia 19:107-114 (Pubitemid 29170106)
19. D'Amico D, Mosconi P, Genco S et al (2001) The migraine disability assessment (MIDAS) questionnaire: translation and reliability of the Italian version. Cephalalgia 21:947-952 (Pubitemid 34626030)
20. Ashkenazi A, Silberstein S, Jakubowski M, Burstein R (2007) Improved identification of allodynic migraine patients using a questionnaire. Cephalalgia 27:325-329 (Pubitemid 46434961)
21. Ware JE, Kosinski M, Dewey JE (2000) How to score version 2 of the SF-36 (r) health survey. Quality Metric Incorporated, Lincoln
22. Sivák S, Bittšanský M, Kurča E, Turčanová-Koprušáková M, Grofik M, Nosál' V, Poláček H, Dobrota D (2010) Proton magnetic resonance spectroscopy in patients with early stages of amyotrophic lateral sclerosis. Neuroradiology 52(12):1079-1085
23. Chakraborty G, Mekala P, Yahya D, Wu G, Ledeen RW (2001) Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase. J Neurochem 78:736-745 (Pubitemid 32777975)
24. Kadota T, Horinouchi T, Kuroda C (2001) Development and aging of the cerebrum: assessment with proton MR Spectroscopy. Am J Neuroradiol 22:128-135 (Pubitemid 32105365)
25. Pan JW, Takahashi K (2005) Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain. Ann Neurol 57:92-97 (Pubitemid 40053319)
26. Lian XY, Stringer JL (2004) Energy failure in astrocytes increases the vulnerability of neurons to spreading depression. Eur J Neurosci 19(9):2446-2454 (Pubitemid 38621842)
27. Sangiorgi S, Mochi M, Riva R, Cortelli P, Monari L, Pierangeli G, Montagna P (1994) Abnormal platelet mitochondrial function in patients affected by migraine with and without aura. Cephalalgia 14(1):21-23 (Pubitemid 24109965)
28. Folbergrová J, Kunz WS (2012) Mitochondrial dysfunction in epilepsy. Mitochondrion 12(1):35-40
29. Li F, Qiu E, Dong Z, Liu R, Wu S, Yu S (2011) Protection of flunarizine on cerebral mitochondria injury induced by cortical spreading depression under hypoxic conditions. J Headache Pain 12(1):47-53
30. Ayata C (2010) Cortical spreading depression triggers migraine attack: pro. Headache 50(4):725-730
31. Vargas BB (2008) Tension-type headache and migraine: two points on a continuum? Curr Pain Headache Rep 12(6):433-436
32. Rossi P, Vollono C, Valeriani M, Sandrini G (2011) The contribution of clinical neurophysiology to the comprehension of the tension-type headache mechanisms. Clin Neurophysiol 122(6): 1075-1085