The right heart in athletes: Evidence for exercise-induced arrhythmogenic right ventricular cardiomyopathy

Herzschrittmachertherapie und Elektrophysiologie

Volumn 23, Issue 2, 2012, Pages 82-86

  Heidbuchel H ^a   La Gerche, A ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Physical activity; Right ventricle; Sports cardiology; Sudden death; Ventricular arrhythmias

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; HEART ENZYME; ILLICIT DRUG;

ARTICLE; ATHLETE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RISK; DISEASE PREDISPOSITION; ENDURANCE TRAINING; EXERCISE; GENETIC PREDISPOSITION; HEART DILATATION; HEART HEMODYNAMICS; HEART PROARRHYTHMIA; HEART RIGHT VENTRICLE DYSPLASIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE REMODELING; HEART VENTRICLE WALL; HUMAN; SPORT INJURY; SUDDEN DEATH; WALL STRESS;

ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; ATHLETES; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; MALE; PREVALENCE; SPORTS;

EID: 84865378249     PISSN: 09387412     EISSN: 14351544     Source Type: Journal    
DOI: 10.1007/s00399-012-0180-3     Document Type: Article

References (33)

1. Argiento P, Chesler N, Mule M et al (2010) Exercise stress echocardiography for the study of the pulmonary circulation. Eur Respir J 35:1273-1278
2. Baldesberger S, Bauersfeld U, Candinas R et al (2008) Sinus node disease and arrhythmias in the long-term follow-up of former professional cyclists. Eur Heart J 29:71-78
3. Benito B, Gay-Jordi G, Serrano-Mollar A et al (2011) Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training. Circulation 123:13-22
4. Bidart CM, Abbas AE, Parish JM et al (2007) The noninvasive evaluation of exercise-induced changes in pulmonary artery pressure and pulmonary vascular resistance. J Am Soc Echocardiogr 20:270-275
5. Corrado D, Basso C, Rizzoli G et al (2003) Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 42:1959-1963 (Pubitemid 37485572)
6. Davila-Roman VG, Guest TM, Tuteur PG et al (1997) Transient right but not left ventricular dysfunction after strenuous exercise at high altitude. J Am Coll Cardiol 30:468-473 (Pubitemid 27339327)
7. Dello Russo A, Pieroni M, Santangeli P et al (2011) Concealed cardiomyopathies in competitive athletes with ventricular arrhythmias and an apparently normal heart: role of cardiac electroanatomical mapping and biopsy. Heart rhythm 8:1915-1922
8. Douglas PS, O'Toole ML, Hiller WD, Reichek N (1990) Different effects of prolonged exercise on the right and left ventricles. J Am Coll Cardiol 15:64-69 (Pubitemid 20034251)
9. Ector J, Ganame J, Merwe N van der et al (2007) Reduced right ventricular ejection fraction in endurance athletes presenting with ventricular arrhythmias: a quantitative angiographic assessment. Eur Heart J 28:345-353
10. Heidbuchel H, Hoogsteen J, Fagard R et al (2003) High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification. Eur Heart J 24:1473-1480 (Pubitemid 37010576)
11. Kirchhof P, Fabritz L, Zwiener M et al (2006) Age-and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation 114:1799-1806 (Pubitemid 44673354)
12. La Gerche A, Burns AT, Mooney DJ et al (2011) Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J
13. La Gerche A, Connelly KA, Mooney DJ et al (2008) Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise. Heart 94:860-866 (Pubitemid 351914694)
14. La Gerche A, Heidbuchel H, Burns AT et al (2011) Disproportionate exercise load and remodeling of the athlete's right ventricle. Med Sci Sports Exerc 43:974-981
15. La Gerche A, MacIsaac AI, Burns AT et al (2010) Pulmonary transit of agitated contrast is associated with enhanced pulmonary vascular reserve and right ventricular function during exercise. J Appl Physiol 109:1307-1317
16. La Gerche A, Robberecht C, Kuiperi C et al (2010) Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. Heart 96:1268-1274
17. Marcus FI, McKenna WJ, Sherrill D et al (2010) Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Eur Heart J 31:806-814
18. Maron BJ, Doerer JJ, Haas TS et al (2009) Sudden deaths in young competitive athletes: analysis of 1866 deaths in the united states, 1980-2006. Circulation 119:1085-1092
19. Modesti PA, Vanni S, Bertolozzi I et al (2004) Different growth factor activation in the right and left ventricles in experimental volume overload. Hypertension 43:101-108 (Pubitemid 38031917)
20. Mousavi N, Czarnecki A, Kumar K et al (2009) Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol 103:1467-1472
21. Neilan TG, Januzzi JL, Lee-Lewandrowski E et al (2006) Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the boston marathon. Circulation 114:2325-2333 (Pubitemid 44847449)
22. Neumayr G, Gaenzer H, Pfister R et al (2001) Plasma levels of cardiac troponin i after prolonged strenuous endurance exercise. Am J Cardiol 87:369-371, A10 (Pubitemid 32144890)
23. Oxborough D, Shave R, Warburton D et al (2011) Dilatation and dysfunction of the right ventricle immediately after ultraendurance exercise: exploratory insights from conventional two-dimensional and speckle tracking echocardiography. Circ Cardiovasc Imaging 4:253-263
24. Scharhag J, Herrmann M, Urhausen A et al (2005) Independent elevations of n-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 150:1128-1134 (Pubitemid 41773512)
25. Sen-Chowdhry S, Syrris P, McKenna WJ (2007) Role of genetic analysis in the management of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 50:1813-1821 (Pubitemid 350007965)
26. Sen-Chowdhry S, Syrris P, Ward D et al (2007) Clinical and genetic characterization of families with arrhythmogenic right ventricular dysplasia/cardiomyopathy provides novel insights into patterns of disease expression. Circulation 115:1710-1720 (Pubitemid 46648607)
27. Shave R, Baggish A, George K et al (2010) Exercise-induced cardiac troponin elevation: Evidence, mechanisms, and implications. J Am Coll Cardiol 56:169-176
28. Shave R, Dawson E, Whyte G et al (2004) Altered cardiac function and minimal cardiac damage during prolonged exercise. Med Sci Sports Exerc 36:1098-1103 (Pubitemid 38878981)
29. Stickland MK, Welsh RC, Haykowsky MJ et al (2004) Intra-pulmonary shunt and pulmonary gas exchange during exercise in humans. J Physiol 561:321-329 (Pubitemid 39549487)
30. Stickland MK, Welsh RC, Petersen SR et al (2006) Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 100:1895-1901 (Pubitemid 43845864)
31. Teske AJ, Prakken NH, De Boeck BW et al (2009) Echocardiographic tissue deformation imaging of right ventricular systolic function in endurance athletes. Eur Heart J 30:969-977
32. Wilson M, O'Hanlon R, Prasad S et al (2011) Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. J Appl Physiol 110:1622-1626
33. Wilson M, O'Hanlon R, Prasad S et al (2011) Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise. Br J Sports Med 45:780-784