Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: A promising tool for early detection of COPD and lung cancer in smokers

Diagnostic Pathology

Volumn 7, Issue 1, 2012, Pages

  Guzmán, Leda ^a   Depix, María S ^b   Salinas, Ana M ^b   Roldán, Rosa ^c   Aguayo, Francisco ^d   Silva, Alejandra ^b   Vinet, Raul ^e,f  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^b UNIVERSIDAD SANTO TOMÁS   (Chile)

^c HOSPITAL SAN JOSÉ   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

^e UNIVERSIDAD DE VALPARAÍSO   (Chile)

^f Centro Regional de Estudios en Alimentos Saludables Valparaiso   (Chile)

Author keywords

COPD; DNA methylation; Lung cancer; Sputum

Indexed keywords

DNA; TUMOR MARKER;

ADULT; AGED; ARTICLE; CHEMISTRY; CHRONIC OBSTRUCTIVE LUNG DISEASE; DNA METHYLATION; EARLY DIAGNOSIS; GENETICS; HUMAN; LUNG TUMOR; METHODOLOGY; MIDDLE AGED; PROMOTER REGION; SMOKING; SPUTUM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; DNA; DNA METHYLATION; EARLY DETECTION OF CANCER; GENES, TUMOR SUPPRESSOR; HUMANS; LUNG NEOPLASMS; MIDDLE AGED; PROMOTER REGIONS, GENETIC; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; SPUTUM; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84865339641     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-7-87     Document Type: Article

References (55)

1. Broekhuizen BD, Sachs AP, Hoes AW, Verheij TJ, Moons KG. Diagnostic management of chronic obstructive pulmonary disease. Neth J Med 2012, 70:6-11.
2. Tockman MS, Erozan YS, Gupta P, Piantadosi S, Mulshine JL. Ruckdeschel: The early detection of second primary lung cancers by sputum immunostaining. LCEWDG Investigators. Lung Cancer Early Detection Group. Chest 1994, 106:385S-390S. 10.1378/chest.106.2.385, 7988270.
3. Kiri VA, Soriano J, Visick G, Fabbri L. Recent trends in lung cancer and its association with COPD: an analysis using the UK GP Research Database. Prim Care Respir J 2010, 19:57-61. 10.4104/pcrj.2009.00048, 19756330.
4. Steiling K, Lenburg ME, Spira A. Airway gene expression in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009, 6:697-700. 10.1513/pats.200907-076DP, 2797071, 20008878.
5. Kim V, Rogers TJ, Criner GJ. New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2008, 5:478-485. 10.1513/pats.200802-014ET, 2645323, 18453359.
6. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: Gold executive summary. Am J Respir Crit Care Med 2007, 176:532-555. 10.1164/rccm.200703-456SO, 17507545.
7. Pisani P, Bray F, Parkim DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 2002, 97:72-81. 10.1002/ijc.1571, 11774246.
8. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics. Cancer J Clinn 2001, 51:15-36.
9. Purdue MP, Gold L, Järvholm B, Alavanja MC, Ward MH, Vermeulen R. Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers. Thorax 2007, 62:51-6. 10.1136/thx.2006.064196, 2111275, 16928722.
10. Mina N, Soubani AO, Cote ML, Suwan T, Wenzlaff AS, Jhajhria S, Samarah H, Schwartz AG. The relationship between chronic obstructive pulmonary disease and lung cancer in African American patients. Clin Lung Cancer 2012, 13:149-56. 10.1016/j.cllc.2011.09.006, 22129972.
11. Cassidy A, Duffy SW, Myles JP, Liloglou T, Field JK. Lung cancer risk prediction: a tool for early detection. Int J Cancer 2007, 120:1-6.
12. Thunnissen FB. Sputum examination for early detection of lung cancer. J Clin Pathol 2003, 56:805-10. 10.1136/jcp.56.11.805, 1770101, 14600122.
13. Bednarek M, Gorecka D, Wielgomas J, Czajkowska-Malinowska M, Regula J, Mieszko-Filipczyk G, Jasionowicz M, Bijata-Bronisz R, Lempicka-Jastrzebska M, Czajkowski M, Przybylski G, Zielinski J. Smokers with airway obstruction are more likely to quit smoking. Thorax 2006, 61:869-73. 10.1136/thx.2006.059071, 2104752, 16809415.
14. Wistuba II, Mao L, Gazdar AF. Smoking molecular damage in bronchial epithelium. Oncogene 2002, 21:7298-7306. 10.1038/sj.onc.1205806, 12379874.
15. Mannino DM, Ford ES, Redd SC. Obstructive and restrictive lung disease and markers of inflammation: Data from the third national health and nutrition examination. Am J Med 2003, 114:758-762. 10.1016/S0002-9343(03)00185-2, 12829203.
16. Brody JS, Spira A. State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc 2006, 3:535-537. 10.1513/pats.200603-089MS, 16921139.
17. Kikuchi S, Yamada D, Fukami T, Maruyama T, Ito A, Asamura H, Matsuno Y, Onizuka M, Murakami Y. Hypermethylation of the tslc1/igsf4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma. Cancer 2006, 106:1751-1758. 10.1002/cncr.21800, 16534787.
18. Besaratinia A, Van Straaten HW, Godschalk RW, Van Zandwijk N, Balm AJ, Kleinjans JC, Van Schooten FJ. Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adducts in mouth floor and buccal mucosa cells of smokers and nonsmokers. Environ Mol Mutagen 2000, 36:127-133. 10.1002/1098-2280(2000)36:2<127::AID-EM7>3.0.CO;2-G, 11013411.
19. Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in copd. Eur Respir J 2006, 28:219-242. 10.1183/09031936.06.00053805, 16816350.
20. Guzmán LM, Koriyama C, Akiba S, Eizuru Y, Castillo D, Corvalan A, Aguayo FR. High frequency of p16 promoter methylation in non-small cell lung carcinomas from chile. Biol Res 2007, 40:365-372.
21. Adonis W, Aguayo FR, Cordero E, RodrÍguez L, Castillo D, Guzmán LM. Evaluación de hipermetilación del gen p16INK4a en cáncer escamoso de pulmón en pacientes chilenos. Rev chil enferm respir 2006, 22:7-12.
22. Hillemacher T, Frieling H, Moskau S, Muschler MA, Semmler A, Kornhuber J, Klockgether T, Bleich S, Linnebank M. Global DNA methylation is influenced by smoking behaviour. Eur Neuropsychopharmacol 2008, 18:295-298. 10.1016/j.euroneuro.2007.12.005, 18242065.
23. Paci M, Maramotti S, Bellesia E, Formisano D, Albertazzi L, Ricchetti T, Ferrari G, Annessi V, Lasagni D, Carbonelli C, De Franco S, Brini M, Sgarbi G, Lodi R. Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer. Lung Cancer 2009, 64:92-97. 10.1016/j.lungcan.2008.07.012, 18804892.
24. Zeerleder S. The struggle to detect circulating DNA. Crit Care 2006, 10:142. 10.1186/cc4932, 1550959, 16719935.
25. Berger JH, Bardeesy N. Modeling ink4/arf tumor suppression in the mouse. Curr Mol Med 2007, 7:63-75. 10.2174/156652407779940477, 17311533.
26. Belinsky SA, Palmisano WA, Gilliland FD, Crooks LA, Divine KK, Winters SA, Grimes MJ, Harms HJ, Tellez CS, Smith TM, Moots PP, Lechner JF, Stidley CA, Crowell RE. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res 2002, 62:2370-2377.
27. Elloul S, Silins I, Trope CG, Benshushan A, Davidson B, Reich R. Expression of e-cadherin transcriptional regulators in ovarian carcinoma. Virchows Arch 2006, 449:520-528. 10.1007/s00428-006-0274-6, 17024425.
28. Amigo H, Erazo M, Oyarzun M, Bello S, Peruga A. smoking and chronic obstructive pulmonary disease: Attributable risk determination. Rev Med Chil 2006, 134:1275-1282.
29. MINSAL Encuesta nacional de salud 2010 2010, , , MINSAL.
30. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E. Collaboration with Sobin LH and Pathologists from 14 Countries: World Health Organization International Histological Classification of Tumours. Histological Typing of Lung and Pleural Tumours 1999, Springer, , 3.
31. Saccomanno G. Sputum cytology. Mayo Clin Proc 1994, 69:97.
32. Saccomanno G. Diagnostic Pulmonary Cytology 1986, American Society of Clinical Pathologists Press, Chicago, 2 1-211.
33. Steinau M, Rajeevan MS, Unger ER. DNA and RNA references for qRT-PCR assays in exfoliated cervical cells. J Mol Diagn 2006, 8:113-8. 10.2353/jmoldx.2006.050088, 1867570, 16436642.
34. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific pcr: A novel pcr assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996, 93:9821-9826. 10.1073/pnas.93.18.9821, 38513, 8790415.
35. Chan HK, Eberl S, Daviskas E, Constable C, Young I. Changes in lung deposition of aerosols due to hygroscopic growth: A fast spect study. J Aerosol Med 2002, 15:307-311. 10.1089/089426802760292654, 12396419.
36. van der Drift MA, Prinsen CF, Hol BE, Bolijn AS, Jeunink MA, Dekhuijzen PN, Thunnissen FB. Can free DNA be detected in sputum of lung cancer patients?. Lung Cance 2008, 61:385-90.
37. Anker P, Lyautey J, Lederrey C, Stroun M. Circulating nucleic acids in plasma or serum. Clin Chim Acta 2001, 313:143-146. 10.1016/S0009-8981(01)00666-0, 11694252.
38. Sozzi G, Conte D, Leon M, Ciricione R, Roz L, Ratcliffe C, Roz E, Cirenei N, Bellomi M, Pelosi G, Pierotti MA, Pastorino U. Quantification of free circulating DNA as a diagnostic marker in lung cancer. J Clin Oncol 2003, 21:3902-3908. 10.1200/JCO.2003.02.006, 14507943.
39. Ji M, Zhang Y, Shi B, Hou P. Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC. Diagn Pathol 2011, 4. 6:48.
40. Zochbauer-Muller S, Minna JD, Gazdar AF. Aberrant DNA methylation in lung cancer: Biological and clinical implications. Oncologist 2002, 7:451-457. 10.1634/theoncologist.7-5-451, 12401908.
41. Safar AM, Spencer H. Su X, Coffey M, Cooney CA, Ratnasinghe LD, Hutchins LF, Fan CY: Methylation profiling of archived non-small cell lung cancer: A promising prognostic system. Clin Cancer Res 2005, 11:4400-4405. 10.1158/1078-0432.CCR-04-2378, 15958624.
42. Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, Haney J, Kennedy TC, Hirsch FR, Miller Y, Franklin WA, Herman JG, Baylin SB, Bunn PA, Byers T. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 2006, 66:3338-3344. 10.1158/0008-5472.CAN-05-3408, 16540689.
43. Palmisano WA, Divine KK, Saccomanno G, Gilliland FD, Baylin SB, Herman JG, Belinsky SA. Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 2000, 60:5954-8.
44. Liu Y, Lan Q, Siegfried JM, Luketich JD, Keohavong P. Aberrant promoter methylation of p16 and mgmt genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 2006, 8:46-55. 10.1593/neo.05586, 1584289, 16533425.
45. Pulling LC, Divine KK, Klinge DM, Gilliland FD, Kang T, Schwartz AG, Bocklage TJ, Belinsky SA. Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: More common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Res 2003, 63:4842-4848.
46. Subramanian J, Govindan R. Lung cancer in never smokers: A review. J Clin Oncol 2007, 25:561-57. 10.1200/JCO.2006.06.8015, 17290066.
47. Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, Fukuyama Y, Virmani AK, Zochbauer-Muller S, Tsukuda K, Sugio K, Shimizu N, Shimizu K, Lee H, Chen CY, Fong KM, Gilcrease M, Roth JA, Minna JD, Gazdar AF. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 2003, 103:153-160. 10.1002/ijc.10787, 12455028.
48. Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L, Westra WH, Yang SC, Jen J, Sidransky D. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res 2001, 61:1309-1313.
49. Divine KK, Pulling LC, Marron-Terada PG, Liechty KC, Kang T, Schwartz AG, Bocklage TJ, Coons TA, Gilliland FD, Belinsky SA. Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. Int J Cancer 2005, 114:400-405. 10.1002/ijc.20761, 15578700.
50. Domagala-Kulawik J, Maskey-Warzechowska M, Kraszewska I, Chazan R. The cellular composition and macrophage phenotype in induced sputum in smokers and ex-smokers with COPD. Chest 2003, 123:1054-1059. 10.1378/chest.123.4.1054, 12684293.
51. Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: Importance in inflammatory lung diseases. Eur Respir J 2005, 25:552-563. 10.1183/09031936.05.00117504, 15738302.
52. Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, Belinsky SA. Carcinogen-induced gene promoter hypermethylation is mediated by dnmt1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res 2008, 68:9005-9014. 10.1158/0008-5472.CAN-08-1276, 18974146.
53. Schottenfeld D, Beebe-Dimmer J. Alleviating the burden of cancer: A perspective on advances, challenges, and future directions. Cancer Epidemiol Biomarkers Prev 2006, 15:2049-2055. 10.1158/1055-9965.EPI-06-0603, 17119027.
54. Vineis P, Husgafvel-Pursiainen K. Air pollution and cancer: Biomarker studies in human populations. Carcinogenesis 2005, 26:1846-1855. 10.1093/carcin/bgi216, 16123121.
55. Kubo T, Yamamoto H, Ichimura K, Jida M, Hayashi T, Otani H, Tsukuda K, Sano Y, Kiura K, Toyooka S. DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components. Lung Cancer 2009, 65:328-332. 10.1016/j.lungcan.2008.12.001, 19144441.