Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 11, 2012, Pages 1783-1795

  Ozaki, Taku ^a,b   Nakazawa, Mitsuru ^b   Yamashita, Tetsuro ^c   Sorimachi, Hiroyuki ^d   Hata, Shoji ^d   Tomita, Hiroshi ^e   Isago, Hitomi ^e   Baba, Ayaka ^a   Ishiguro, Sei ichi ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c IWATE UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

Apoptosis inducing factor; Calpain; Mitochondria; Peptide; Retinal photoreceptor degeneration; Retinitis pigmentosa

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALPAIN; CATHEPSIN; MU CALPAIN N2; MU CALPAIN N9; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ENZYME ACTIVITY; ENZYME STRUCTURE; IC 50; LIVER CYTOSOL; LIVER MITOCHONDRION; NICK END LABELING; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; RAT; RETINITIS PIGMENTOSA; SURGEON; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CALPAIN; DISEASE MODELS, ANIMAL; HUMANS; INTRAVITREAL INJECTIONS; MITOCHONDRIA, LIVER; MOLECULAR SEQUENCE DATA; OPHTHALMIC SOLUTIONS; PEPTIDES; PHOTORECEPTOR CELLS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RETINITIS PIGMENTOSA; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 84865339319     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.07.018     Document Type: Article

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